{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:35:32Z","timestamp":1794000932976,"version":"4.8.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"DOI":"10.1210\/jc.2009-0417","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T01:34:24Z","timestamp":1252460064000},"page":"3806-3815","source":"Crossref","is-referenced-by-count":139,"title":["Sex Hormones and Frailty in Older Men: The Osteoporotic Fractures in Men (MrOS) Study"],"prefix":"10.1210","volume":"94","author":[{"given":"Peggy M.","family":"Cawthon","sequence":"first","affiliation":[{"name":"Research Institute (P.M.C., S.R.C.), California Pacific Medical Center, San Francisco, California 94107-1728"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"University of Minnesota and Minneapolis VA Medical Center (K.E.E.), Minneapolis, Minnesota 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine (G.A.L., E.B.-C.), University of California at San Diego, La Jolla, California 92103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh (J.A.C.), Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy-Tien L.","family":"Dam","sequence":"additional","affiliation":[{"name":"Department of Medicine (T.-T.L.D.), Columbia University, New York, New York 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Barrett-Connor","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine (G.A.L., E.B.-C.), University of California at San Diego, La Jolla, California 92103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Fink","sequence":"additional","affiliation":[{"name":"University of Minnesota (H.A.F.), Geriatric Research Education and Clinical Center, VA Medical Center, and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Veterans Affairs Palo Alto Health Care System and Stanford University Medical Center (A.R.H.), Palo Alto, California 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lau","sequence":"additional","affiliation":[{"name":"Center for Health and Medical Research (E.L.), Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.E.L.), University of California at Davis Medical School, Sacramento, California 95817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia L.","family":"Stefanick","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center (M.L.S.), Stanford School of Medicine, Stanford, California 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Research Institute (P.M.C., S.R.C.), California Pacific Medical Center, San Francisco, California 94107-1728"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Orwoll","sequence":"additional","affiliation":[{"name":"Bone and Mineral Unit (E.S.O.), Oregon Health and Science University, Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Osteoporotic Fractures in Men (MrOS) Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113461567200_R1","first-page":"1387","article-title":"Frailty and failure to thrive","author":"Fried","year":"1998","journal-title":"In: Hazzard WR, Blass JP, Ettinger WHJ, Halter JB, Ouslander J, eds. Principles of geriatric medicine and gerontology. 4th ed. New York: McGraw Hill;"},{"key":"key\n\t\t\t\t2019041113461567200_R2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1532-5415.2006.00745.x","article-title":"Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society\/National Institute on Aging Research Conference on Frailty in Older Adults.","volume":"54","author":"Walston","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R3","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/gerona\/61.3.262","article-title":"Phenotype of frailty: characterization in the women\u2019s health and aging studies.","volume":"61","author":"Bandeen-Roche","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1532-5415.2005.53300.x","article-title":"The association between obesity and the frailty syndrome in older women: the Women\u2019s Health and Aging Studies.","volume":"53","author":"Blaum","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/gerona\/62.7.744","article-title":"Frailty and risk of falls, fracture and mortality in older women: the study of osteoporotic fractures.","volume":"62","author":"Ensrud","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R7","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1532-5415.2005.53405.x","article-title":"Frailty: emergence and consequences in women aged 65 and older in the Women\u2019s Health Initiative Observational Study","volume":"53","author":"Woods","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R8","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1532-5415.2007.01259.x","article-title":"Frailty in older men: prevalence, progression and relation to mortality.","volume":"55","author":"Cawthon","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/er.2004-0013","article-title":"The decline of androgen levels in elderly men and its clinical and therapeutic implications.","volume":"26","author":"Kaufman","year":"2005","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113461567200_R10","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1002\/cncr.23084","article-title":"Does androgen-deprivation therapy accelerate the development of frailty in older men with prostate cancer? A conceptual review.","volume":"110","author":"Bylow","year":"2007","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019041113461567200_R11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1532-5415.2007.01121.x","article-title":"Testosterone, sex hormone-binding globulin, and frailty in older men.","volume":"55","author":"Mohr","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cct.2005.05.005","article-title":"Overview of recruitment for the osteoporotic fractures in men study (MrOS).","volume":"26","author":"Blank","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"key\n\t\t\t\t2019041113461567200_R13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cct.2005.05.006","article-title":"Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study\u2014a large observational study of the determinants of fracture in older men.","volume":"26","author":"Orwoll","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"key\n\t\t\t\t2019041113461567200_R14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","article-title":"The Physical Activity Scale for the Elderly (PASE): development and evaluation.","volume":"46","author":"Washburn","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041113461567200_R15","author":"Ware","year":"1998"},{"key":"key\n\t\t\t\t2019041113461567200_R16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF01719664","article-title":"Drug data coding and analysis in epidemiologic studies.","volume":"10","author":"Pahor","year":"1994","journal-title":"Eur J Epidemiol"},{"key":"key\n\t\t\t\t2019041113461567200_R17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0022-4731(82)90038-3","article-title":"Calculation of free and bound fractions of testosterone and estradiol-17 \u03b2 to human plasma proteins at body temperature.","volume":"16","author":"So\u0308derga\u030ard","year":"1982","journal-title":"J Steroid Biochem"},{"key":"key\n\t\t\t\t2019041113461567200_R18","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum.","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R19","year":"2004"},{"key":"key\n\t\t\t\t2019041113461567200_R20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0895-4356(96)00312-5","article-title":"Statistical assessment of ordinal outcomes in comparative studies.","volume":"50","author":"Scott","year":"1997","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041113461567200_R21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1210\/jc.2003-032175","article-title":"Serum testosterone assays\u2014accuracy matters.","volume":"89","author":"Matsumoto","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R22","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1373\/49.8.1381","article-title":"Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children.","volume":"49","author":"Taieb","year":"2003","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113461567200_R23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2003-031287","article-title":"Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry.","volume":"89","author":"Wang","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archinternmed.2007.113","article-title":"Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women.","volume":"168","author":"Ensrud","year":"2008","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113461567200_R25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1532-5415.2009.02137.x","article-title":"A comparison of frailty indexes for the prediction of falls, disability, fractures and mortality in older men.","volume":"57","author":"Ensrud","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R26","doi-asserted-by":"crossref","first-page":"M627","DOI":"10.1093\/gerona\/59.6.M627","article-title":"The estimation of relative fitness and frailty in community-dwelling older adults using self-report data","volume":"59","author":"Mitnitski","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R27","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/gerona\/59.12.1310","article-title":"Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging.","volume":"59","author":"Rockwood","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R28","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/j.1532-5415.2004.52423.x","article-title":"Clinical global impression of change in physical frailty: development of a measure based on clinical judgment.","volume":"52","author":"Studenski","year":"2004","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113461567200_R29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1043-2760(03)00083-3","article-title":"Sex hormones and male health: effects on components of the frailty syndrome.","volume":"14","author":"Muller","year":"2003","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R30","first-page":"821","article-title":"Selective androgen receptor modulators for frailty and osteoporosis.","volume":"8","author":"Kilbourne","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"key\n\t\t\t\t2019041113461567200_R31","doi-asserted-by":"crossref","first-page":"E601","DOI":"10.1152\/ajpendo.00362.2001","article-title":"Testosterone administration to older men improves muscle function: molecular and physiological mechanisms","volume":"282","author":"Ferrando","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/jc.2005-1097","article-title":"Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men.","volume":"91","author":"Maggio","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113461567200_R33","first-page":"116","article-title":"The relationship between testosterone and molecular markers of inflammation in older men.","volume":"28","author":"Maggio","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113461567200_R34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/gerona\/59.3.M242","article-title":"Inflammatory markers and physical performance in older persons: the InCHIANTI study.","volume":"59","author":"Cesari","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113461567200_R35","article-title":"Inflammation and frailty measures in older people","author":"Hubbard","year":"6 2009","journal-title":"J Cell Mol Med"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/94\/10\/3806\/9058590\/jcem3806.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T12:37:24Z","timestamp":1558528644000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/94\/10\/3806\/2596871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,1]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-0417","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,1]]}}}