{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:14Z","timestamp":1790254274920,"version":"4.1.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"DOI":"10.1210\/jc.2009-0568","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T01:55:08Z","timestamp":1253670908000},"page":"4300-4308","source":"Crossref","is-referenced-by-count":19,"title":["Anthropometric and Skeletal Phenotype in Men with Idiopathic Osteoporosis and Their Sons Is Consistent with Deficient Estrogen Action during Maturation"],"prefix":"10.1210","volume":"94","author":[{"given":"Bruno","family":"Lapauw","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youri","family":"Taes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Goemaere","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaatje","family":"Toye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Georg","family":"Zmierczak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113525365500_R1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1359\/jbmr.070606","article-title":"Heritability of BMD of femoral neck and lumbar spine: a multivariate twin study of Finnish men.","volume":"22","author":"Videman","year":"2007","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R2","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1210\/jc.2008-0678","article-title":"Genome-wide linkage screen of bone mineral density (BMD) in European pedigrees ascertained through a male relative with low BMD values: evidence for quantitative trait loci on 17q21-23, 11q12-13, 13q12-14, and 22q11.","volume":"93","author":"Kaufman","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R3","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1359\/jbmr.1998.13.12.1909","article-title":"Bone mass in middle-aged osteoporotic men and their relatives: familial effect.","volume":"13","author":"Cohen-Solal","year":"1998","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R4","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1210\/jcem.87.5.8496","article-title":"Genetic and environmental factors affect bone density variances of families of men and women with osteoporosis.","volume":"87","author":"Baudoin","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2265.2006.02690.x","article-title":"Decreased spinal and femoral neck volumetric bone mineral density (BMD) in men with primary osteoporosis and their first-degree male relatives: familial effect on BMD in men.","volume":"66","author":"Erbas","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113525365500_R6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1359\/jbmr.2003.18.2.303","article-title":"Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study.","volume":"18","author":"Van Pottelbergh","year":"2003","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R7","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1210\/jc.2003-032081","article-title":"Perturbed sex steroid status in men with idiopathic osteoporosis and their sons.","volume":"89","author":"Van Pottelbergh","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00223-001-2018-6","article-title":"Low body size and elevated sex-hormone binding globulin distinguish men with idiopathic vertebral fracture.","volume":"70","author":"Evans","year":"2002","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113525365500_R9","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00198-006-0223-x","article-title":"Muscle mass deficits are associated with bone mineral density in men with idiopathic vertebral fracture.","volume":"18","author":"Macdonald","year":"2007","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113525365500_R10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092190104","article-title":"Bone \u201cmass\u201d and the \u201cmechanostat\u201d: a proposal.","volume":"219","author":"Frost","year":"1987","journal-title":"Anat Rec"},{"key":"key\n\t\t\t\t2019041113525365500_R11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s002239900604","article-title":"Decreased estradiol levels and free androgen index and elevated sex hormone-binding globulin levels in male idiopathic osteoporosis.","volume":"64","author":"Gillberg","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113525365500_R12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S8756-3282(01)00478-1","article-title":"Osteoporosis in men: a potential role for the sex hormone binding globulin.","volume":"29","author":"Legrand","year":"2001","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113525365500_R13","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1210\/jc.2003-030736","article-title":"Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men.","volume":"88","author":"Gennari","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R14","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ajcn\/36.5.936","article-title":"A short questionnaire for the measurement of habitual physical activity in epidemiological studies.","volume":"36","author":"Baecke","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t2019041113525365500_R15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s001980050093","article-title":"Updated data on proximal femur bone mineral levels of US adults.","volume":"8","author":"Looker","year":"1998","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113525365500_R16","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum.","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2265.2004.02117.x","article-title":"Assessment of the role of 17\u03b2-oestradiol in bone metabolism in men: does the assay technique matter? The MINOS Study.","volume":"61","author":"Szulc","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113525365500_R18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.bone.2004.12.008","article-title":"Bone histomorphometry in 22 male patients with normocalciuric idiopathic osteoporosis.","volume":"36","author":"Ciria-Recasens","year":"2005","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113525365500_R19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00223-005-0158-9","article-title":"Osteoblast dysfunction in male idiopathic osteoporosis.","volume":"78","author":"Pernow","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113525365500_R20","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(02)08706-8","article-title":"Pathogenesis of bone fragility in women and men.","volume":"359","author":"Seeman","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113525365500_R21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s001980070068","article-title":"Prevalence of low serum estradiol levels in male osteoporosis.","volume":"11","author":"Carlsen","year":"2000","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113525365500_R22","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1046\/j.1365-2362.2001.00836.x","article-title":"Bone turnover markers and sex hormones in men with idiopathic osteoporosis.","volume":"31","author":"Pietschmann","year":"2001","journal-title":"Eur J Clin Invest"},{"issue":"Suppl 1","key":"key\n\t\t\t\t2019041113525365500_R23","first-page":"SA331","article-title":"The relative roles of the sex steroids in idiopathic osteoporosis in men","volume":"18","author":"Kurland","year":"2003","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R24","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1359\/jbmr.081260","article-title":"Serum estradiol is associated with volumetric bone mineral density and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings.","volume":"24","author":"Lapauw","year":"2009","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R25","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1359\/JBMR.050404","article-title":"Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD Study.","volume":"20","author":"Lorentzon","year":"2005","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113525365500_R26","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1210\/jc.2007-2397","article-title":"Impact on bone of an estrogen receptor-\u03b1 gene loss of function mutation.","volume":"93","author":"Smith","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJM199808273390905","article-title":"Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency.","volume":"339","author":"Bilezikian","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113525365500_R28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/jc.2005-1766","article-title":"Sex steroids and the periosteum: reconsidering the roles of androgens and estrogens in periosteal expansion.","volume":"91","author":"Vanderschueren","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.bone.2005.06.017","article-title":"LRP5 gene polymorphisms and idiopathic osteoporosis in men.","volume":"37","author":"Ferrari","year":"2005","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113525365500_R30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bone.2004.01.024","article-title":"Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis.","volume":"34","author":"Lormeau","year":"2004","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113525365500_R31","first-page":"1821","article-title":"Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.","volume":"81","author":"Vermeulen","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R32","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1210\/jc.2002-021691","article-title":"Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age.","volume":"88","author":"Van Pottelbergh","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113525365500_R33","doi-asserted-by":"crossref","first-page":"27285","DOI":"10.1074\/jbc.M702810200","article-title":"Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.","volume":"282","author":"Almeida","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113525365500_R34","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00198-008-0591-5","article-title":"Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density.","volume":"19","author":"Khosla","year":"2008","journal-title":"Osteoporos Int"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/94\/11\/4300\/9058578\/jcem4300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T18:11:18Z","timestamp":1710612678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/94\/11\/4300\/2596489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,1]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-0568","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,1]]}}}