{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:00:50Z","timestamp":1790935250530,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:p>Objective: Previous studies reported independent associations of hematological parameters with risk of incident type 2 diabetes, although limited data are available on associations of these parameters with insulin resistance (IR) and (especially) pancreatic \u03b2-cell dysfunction in large epidemiological studies. Our objective was to evaluate the associations of hematological parameters, including hematocrit (HCT), hemoglobin (Hgb), red blood cell count (RBC), and white blood cell count with IR and \u03b2-cell dysfunction in a cohort of nondiabetic subjects at high metabolic risk.<\/jats:p>\n                  <jats:p>Methods: Nondiabetic subjects (n = 712) were recruited in Toronto and London, Ontario, Canada, between 2004 and 2006, based on the presence of one or more risk factors for type 2 diabetes mellitus including obesity, hypertension, a family history of diabetes, and\/or a history of gestational diabetes. Fasting blood samples were collected and oral glucose tolerance tests administered, with additional samples for glucose and insulin drawn at 30 and 120 min. Measures of IR included the homeostasis model assessment (HOMA-IR) and Matsuda\u2019s insulin sensitivity index, whereas measures of \u03b2-cell dysfunction included the insulinogenic index divided by HOMA-IR as well as the insulin secretion-sensitivity index-2. Associations of hematological parameters with IR and \u03b2-cell dysfunction were assessed using multiple linear regression and analysis of covariance with adjustments for age, gender, ethnicity, smoking, cardiovascular disease, systolic and diastolic blood pressure, and waist circumference.<\/jats:p>\n                  <jats:p>Results: HOMA-IR increased across quartiles of HCT, Hgb, RBC, and white blood cell count after adjustment for age, gender, ethnicity, and smoking (all P (trend) &amp;lt;0.0001). Similarly, there was a strong stepwise decrease in the Matsuda\u2019s insulin sensitivity index across increasing quartiles of these hematological measures (all P (trend) &amp;lt;0.0001). The associations remained significant after further adjustment for previous cardiovascular disease, blood pressure, and waist circumference (all P (trend) &amp;lt;0.0001). Similarly, there was a strong pattern of decreasing \u03b2-cell function across increasing quartiles of all hematological patterns (all P (trend) &amp;lt;0.0001). The findings for HCT, Hgb, and RBC were attenuated slightly after full multivariate adjustment, although the trend across quartiles remained highly significant.<\/jats:p>\n                  <jats:p>Conclusion: These findings suggest that standard, clinically relevant hematological variables may be related to the underlying pathophysiological changes associated with type 2 diabetes mellitus.<\/jats:p>\n                  <jats:p>In a large sample of non-diabetic subjects with metabolic risk factors, hematological parameters were significantly associated with insulin sensitivity and \u03b2-cell dysfunction, the main physiological disorders underlying type 2 diabetes.<\/jats:p>","DOI":"10.1210\/jc.2009-0719","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T21:49:44Z","timestamp":1248212984000},"page":"3824-3832","source":"Crossref","is-referenced-by-count":75,"title":["Association of Hematological Parameters with Insulin Resistance and \u03b2-Cell Dysfunction in Nondiabetic Subjects"],"prefix":"10.1210","volume":"94","author":[{"given":"Anthony J. G.","family":"Hanley","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences (A.J.G.H.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"},{"name":"Division of Endocrinology (A.J.G.H., R.R., B.P., B.Z.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"},{"name":"Leadership Sinai Centre for Diabetes (A.J.G.H., R.R., Y.Q., B.Z.), Mount Sinai Hospital, Toronto, Ontario, Canada M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Retnakaran","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.J.G.H., R.R., B.P., B.Z.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"},{"name":"Leadership Sinai Centre for Diabetes (A.J.G.H., R.R., Y.Q., B.Z.), Mount Sinai Hospital, Toronto, Ontario, Canada M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qi","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (A.J.G.H., R.R., Y.Q., B.Z.), Mount Sinai Hospital, Toronto, Ontario, Canada M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism and the Population Health Research Institute (H.C.G.), Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada L8Z 3N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Perkins","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.J.G.H., R.R., B.P., B.Z.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Raboud","sequence":"additional","affiliation":[{"name":"Department of Medicine, and Division of Infectious Disease (J.R.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"},{"name":"Samuel Lunenfeld Research Institute (J.R., B.Z.), Mount Sinai Hospital, Toronto, Ontario, Canada M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart B.","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Studies in Family Medicine (S.B.H.), University of Western Ontario, London, Ontario, Canada N6A 5B8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Zinman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.J.G.H., R.R., B.P., B.Z.), University Health Network, University of Toronto, Toronto, Canada M5S 3G3"},{"name":"Leadership Sinai Centre for Diabetes (A.J.G.H., R.R., Y.Q., B.Z.), 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