{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:55:57Z","timestamp":1785322557098,"version":"3.55.0"},"reference-count":26,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:p>Context: Type 2 amiodarone-induced thyrotoxicosis (AIT) is a destructive thyroiditis usually responsive to glucocorticoids; however, recent surveys showed that many expert thyroidologists worldwide use thionamides for type 2 AIT patients.<\/jats:p><jats:p>Objective: The objective of the study was to compare the effectiveness of methimazole (MMI) or prednisone (GLU) in type 2 AIT patients who had a short cure time according to a published predictive model.<\/jats:p><jats:p>Design: This was a matched retrospective cohort study.<\/jats:p><jats:p>Setting: The study was conducted at a university center.<\/jats:p><jats:p>Patients: Forty-two untreated type 2 AIT patients with a predicted cure time \u226440 d were divided into two groups (MMI and GLU groups). After matching for the predicted cure time, patients in the GLU group were selected in a 1:1 ratio to patients in the MMI group.<\/jats:p><jats:p>Intervention: Patients were treated with GLU or MMI for 40 d. Patients still thyrotoxic after 40 d continued glucocorticoids if in the GLU group or were switched to prednisone (MMI-GLU group) if in the MMI group.<\/jats:p><jats:p>Main Outcome Measure: Time and rate of cure (healing) at 40 d were measured.<\/jats:p><jats:p>Results: Patients still thyrotoxic after 40 d were 23.8 \u00b1 9.3% in the GLU group and 85.7 \u00b1 7.6% in the MMI group (P = 0.000). The GLU and MMI-GLU groups did not significantly differ in the nonhealing rate at 40 d (P = 0.730). When patients in the MMI group were treated with glucocorticoids, 94.1% patients achieved euthyroidism within 40 d. However, the global median cure time (MMI period + prednisone period) was longer (60 d, 95% confidence interval 53.5\u201366.5 d) in the MMI-GLU group than the GLU group (21 d, 95% confidence interval 15.1\u201326.9 d).<\/jats:p><jats:p>Conclusions: Glucocorticoids are the first-line treatment in type 2 AIT, whereas thionamides play no role in this destructive thyroiditis.<\/jats:p><jats:p>Glucocorticoids are the first-line treatment in type 2 amiodarone-induced thyrotoxicosis while thionamides play no role in this destructive thyroiditis.<\/jats:p>","DOI":"10.1210\/jc.2009-0940","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T01:49:44Z","timestamp":1248227384000},"page":"3757-3762","source":"Crossref","is-referenced-by-count":42,"title":["Glucocorticoids Are Preferable to Thionamides as First-Line Treatment for Amiodarone-Induced Thyrotoxicosis due to Destructive Thyroiditis: A Matched Retrospective Cohort Study"],"prefix":"10.1210","volume":"94","author":[{"given":"Fausto","family":"Bogazzi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism (F.B., L.T., E.D., E.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tomisti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism (F.B., L.T., E.D., E.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council and G. Monasterio Foundation (G.R., P.P.), 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Dell'Unto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism (F.B., L.T., E.D., E.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pepe","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council and G. 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