{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:17Z","timestamp":1791214517037,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"DOI":"10.1210\/jc.2009-1317","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T21:49:36Z","timestamp":1262987376000},"page":"537-544","source":"Crossref","is-referenced-by-count":34,"title":["Management of Cushing\u2019s Syndrome due to Ectopic Adrenocorticotropin Secretion with 1,Ortho-1, Para\u2032-Dichloro-Diphenyl-Dichloro-Ethane: Findings in 23 Patients from a Single Center"],"prefix":"10.1210","volume":"95","author":[{"given":"Bruno","family":"Donadille","sequence":"first","affiliation":[{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Groussin","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Cochin Hospital, and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 567 (L.G., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Waintrop","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halim","family":"Abbas","sequence":"additional","affiliation":[{"name":"Toxicology (H.A.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"Biophysics and Hormonology (F.T., M.-A.D.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Dugue\u0301","sequence":"additional","affiliation":[{"name":"Biophysics and Hormonology (F.T., M.-A.D.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe\u0308l","family":"Coste","sequence":"additional","affiliation":[{"name":"Biostatistics (J.C.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bertagna","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Cochin Hospital, and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 567 (L.G., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u0301ro\u0302me","family":"Bertherat","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Adrenal Diseases and Departments of Endocrinology (B.D., L.G., C.W., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Cochin Hospital, and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 567 (L.G., X.B., J.B.), Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 8104, Institut Cochin, Paris 75014, France"},{"name":"Faculte\u0301 de Me\u0301decine (B.D., L.G., C.W., F.T., M.-A.D., J.C., X.B., J.B.), Paris Descartes University 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113453604700_R1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0140-6736(00)84800-X","article-title":"A case of pluriglandular syndrome: diabetes of bearded women","volume":"212","author":"Brown","year":"1928","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113453604700_R2","first-page":"752","article-title":"Ectopic adrenocorticotropic hormone syndrome","volume":"15","author":"Wajchenberg","year":"1994","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113453604700_R3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/jcem-22-7-693","article-title":"Cause of Cushing\u2019s syndrome in patients with tumors arising from \u201cnonendocrine\u201d tissue","volume":"22","author":"Meador","year":"1962","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R4","first-page":"283","article-title":"Clinical and laboratory studies of ectopic humoral syndromes","volume":"25","author":"Liddle","year":"1969","journal-title":"Recent Prog Horm Res"},{"key":"key\n\t\t\t\t2019041113453604700_R5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing\u2019s syndrome","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113453604700_R6","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/jc.2007-2734","article-title":"Treatment of adrenocorticotropin-dependent Cushing\u2019s syndrome: a consensus statement","volume":"93","author":"Biller","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R7","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1210\/jc.2004-2527","article-title":"Cushing\u2019s syndrome due to ectopic corticotropin secretion: twenty years\u2019 experience at the National Institutes of Health","volume":"90","author":"Ilias","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1210\/jc.2005-1542","article-title":"The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up","volume":"91","author":"Isidori","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJM197107292850501","article-title":"Results of treatment in 108 patients with Cushing\u2019s syndrome","volume":"285","author":"Orth","year":"1971","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113453604700_R10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1210\/jcem-36-3-482","article-title":"Malignant melanoma with ectopic production of adrenocorticotropic hormone. Palliative treatment with inhibitors of adrenal steroid biosynthesis","volume":"36","author":"Carey","year":"1973","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R11","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0046-8177(84)80151-3","article-title":"Cushing\u2019s syndrome produced by a bronchial carcinoid tumor","volume":"15","author":"DeStephano","year":"1984","journal-title":"Hum Pathol"},{"key":"key\n\t\t\t\t2019041113453604700_R12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1507\/endocrj1954.32.615","article-title":"Effect of o,p\u2032-DDD on cortisol metabolism in Cushing\u2019s syndrome of various etiology","volume":"32","author":"Koide","year":"1985","journal-title":"Endocrinol Jpn"},{"key":"key\n\t\t\t\t2019041113453604700_R13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-2265.1988.tb03713.x","article-title":"Characterization of human corticotrophin-releasing hormone and pro-opiomelanocortin-related peptides in a thymic carcinoid tumour responsible for Cushing\u2019s syndrome","volume":"29","author":"Raux Demay","year":"1988","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113453604700_R14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2265.1995.tb01865.x","article-title":"Pseudo-tumours of the thymus after correction of hypercortisolism in patients with ectopic ACTH syndrome: a report of five cases","volume":"42","author":"Tabarin","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113453604700_R15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2265.2005.02403.x","article-title":"Rapidly progressing high o,p\u2032DDD doses shorten the time required to reach the therapeutic threshold with an acceptable tolerance: preliminary results","volume":"64","author":"Faggiano","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113453604700_R16","first-page":"581","article-title":"Adrenal cortical carcinoma. Results of treatment with o,p\u2032DDD in 138 patients","volume":"41","author":"Hutter Jr","year":"1966","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019041113453604700_R17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM196910092811501","article-title":"Treatment of Cushing\u2019s disease. Correction of hypercortisolism by o,p\u2032DDD without induction of aldosterone deficiency","volume":"281","author":"Temple Jr","year":"1969","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113453604700_R18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJM197903013000903","article-title":"Treatment of Cushing\u2019s disease by O,p\u2032DDD. Survey of 62 cases","volume":"300","author":"Luton","year":"1979","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113453604700_R19","first-page":"1325","article-title":"[Long-term treatment of Cushing\u2019s disease using ketoconazole. Possibility of therapeutic escape]","volume":"18","author":"Diop","year":"1989","journal-title":"Presse Med"},{"key":"key\n\t\t\t\t2019041113453604700_R20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.7326\/0003-4819-89-1-128","article-title":"Metyrapone is useful only as adjunctive therapy in Cushing\u2019s disease","volume":"89","author":"Orth","year":"1978","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113453604700_R21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00258213","article-title":"Blood levels of o,p\u2032-DDD following administration in various vehicles after a single dose and during long-term treatment","volume":"7","author":"Moolenaar","year":"1981","journal-title":"Cancer Chemother Pharmacol"},{"key":"key\n\t\t\t\t2019041113453604700_R22","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1210\/jcem-68-5-988","article-title":"Suppression of ectopic adrenocorticotropin secretion by the long-acting somatostatin analog octreotide","volume":"68","author":"Bertagna","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R23","volume-title":"Cushing\u2019s disease. In: The pituitary","author":"Bertagna","year":"2002"},{"key":"key\n\t\t\t\t2019041113453604700_R24","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jc.2003-030871","article-title":"Diagnosis and complications of Cushing\u2019s syndrome: a consensus statement","volume":"88","author":"Arnaldi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R25","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1210\/jc.2008-1171","article-title":"Midnight salivary cortisol determination for assessing the outcome of transsphenoidal surgery in Cushing\u2019s disease","volume":"93","author":"Carrasco","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R26","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1210\/jc.2003-031790","article-title":"Midnight salivary cortisol for the initial diagnosis of Cushing\u2019s syndrome of various causes","volume":"89","author":"Yaneva","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00007691-199906000-00020","article-title":"Determination of mitotane (o,p-DDD) and its metabolites o,p-DDA and o,p-DDE in plasma by high-performance liquid chromatography","volume":"21","author":"Andersen","year":"1999","journal-title":"Ther Drug Monit"},{"key":"key\n\t\t\t\t2019041113453604700_R28","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1210\/jc.2005-1989","article-title":"Image in endocrinology: localization of an occult adrenocorticotropin-secreting carcinoid tumor with somatostatin receptor scintigraphy using single-photon emission computed tomography\/computed tomographic image scanning","volume":"91","author":"Waintrop","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R29","first-page":"20","article-title":"Somatostatin analogs for the localization and preoperative treatment of an adrenocorticotropin-secreting bronchial carcinoid tumor","volume":"78","author":"Phlipponneau","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t2019041113453604700_R31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(78)92515-1","article-title":"Increased urate excretion after o,p\u2032-DDD","volume":"1","author":"Reach","year":"1978","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113453604700_R32","first-page":"4272","article-title":"High plasma proopiomelanocortin in aggressive adrenocorticotropin-secreting tumors","volume":"81","author":"Raffin-Sanson","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R33","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1210\/jc.2001-011813","article-title":"Management of occult adrenocorticotropin-secreting bronchial carcinoids: limits of endocrine testing and imaging techniques","volume":"88","author":"Loli","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R34","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ncpendmet0327","article-title":"Cushing\u2019s syndrome caused by an occult source: difficulties in diagnosis and management","volume":"2","author":"Grossman","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R35","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/archinte.1986.00360170151022","article-title":"Occult ectopic secretion of corticotropin","volume":"146","author":"Findling","year":"1986","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113453604700_R36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF03344109","article-title":"Long-term quiescence of ectopic Cushing\u2019s syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine?","volume":"29","author":"Francia","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113453604700_R37","first-page":"1605","article-title":"[Metastatic pulmonary carcinoma, revealed by Cushing syndrome, initially considered to have a pituitary origin. Course over 25 years]","volume":"24","author":"de Gennes","year":"1995","journal-title":"Presse Med"},{"key":"key\n\t\t\t\t2019041113453604700_R38","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.arcmed.2006.05.015","article-title":"Ectopic ACTH-secreting syndrome: a single center experience report with a high prevalence of occult tumor","volume":"37","author":"Herna\u0301ndez","year":"2006","journal-title":"Arch Med Res"},{"key":"key\n\t\t\t\t2019041113453604700_R39","first-page":"487","article-title":"A critical analysis of the value of simultaneous inferior petrosal sinus sampling in Cushing\u2019s disease and the occult ectopic adrenocorticotropin syndrome","volume":"84","author":"Kaltsas","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R40","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1210\/jc.2005-2157","article-title":"Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans","volume":"91","author":"Nader","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113453604700_R41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.beem.2008.10.008","article-title":"Clinical management of adrenocortical carcinoma","volume":"23","author":"Fassnacht","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/95\/2\/537\/9065154\/jcem0537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T21:51:33Z","timestamp":1558734693000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/95\/2\/537\/2596606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-1317","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718270052.793490687","asserted-by":"object"}]},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,1]]}}}