{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:26:16Z","timestamp":1790015176000,"version":"4.0.1"},"reference-count":37,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:p>Context: The impact of estrogen plus progestin as an oral contraceptive on high density lipoprotein (HDL) apolipoprotein (apo) AI metabolism in humans is poorly understood.<\/jats:p>\n                  <jats:p>Objectives: This study was designed to measure the in vivo effect of Moneva (30 \u03bcg ethinylestradiol, 75 \u03bcg gestodene) on HDL apoAI production rate and fractional catabolic rate.<\/jats:p>\n                  <jats:p>Design: Using 13C-leucine, we performed two kinetic studies in the fed state in 10 normolipidemic young women, before and 3 months after beginning Moneva.<\/jats:p>\n                  <jats:p>Results: On Moneva, serum triglycerides increased by 12% (P = 0.03) in the fed state, whereas low-density lipoprotein and HDL cholesterol remained unchanged. HDL apoAI pool size and production rate were increased by 9.2% (67.3 \u00b1 7.1 vs. 61.6 \u00b1 6.7 mg \u00b7 kg\u22121; P = 0.05) and 26.5% (14.3 \u00b1 2.7 vs. 11.3 \u00b1 2.2 mg \u00b7 kg\u22121 \u00b7 d\u22121; P = 0.02), respectively. HDL apoAI fractional catabolic rate was not significantly modified. Three-month treatment by Moneva induced a shift of HDL size distribution from HDL2 toward HDL3 (HDL3 = 51.5 \u00b1 8.1 vs. 46.5 \u00b1 9.2% of total HDL; P = 0.02) and an increase in the proportion of apoAI among HDL components (38.8 \u00b1 4.3 vs. 34.4 \u00b1 2.8%; P = 0.01).<\/jats:p>\n                  <jats:p>Conclusion: Oral contraception by estrogen plus progestin induces changes in HDL apoAI metabolism characterized by an increase in production rate and pool size, with a higher proportion of HDL3 particles. Whether or not these changes are beneficial to prevent atherosclerosis has to be explored further.<\/jats:p>","DOI":"10.1210\/jc.2009-1402","type":"journal-article","created":{"date-parts":[[2009,10,26]],"date-time":"2009-10-26T21:30:42Z","timestamp":1256592642000},"page":"4891-4897","source":"Crossref","is-referenced-by-count":8,"title":["Increased Apolipoprotein AI Production Rate and Redistribution of High-Density Lipoprotein Size Induced by Estrogen plus Progestin as Oral Contraceptive"],"prefix":"10.1210","volume":"94","author":[{"given":"Laurence","family":"Duvillard","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Dautin","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Florentin","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"},{"name":"Institut Fe\u0301de\u0301ratif de Recherche 100 (E.F., P.G.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Jeannin","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Pais de Barros","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Lagrost","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Petit","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"},{"name":"Department of Endocrinology and Metabolic Diseases (J.-M.P., B.V.), Centre Hospitalier Universitaire Dijon, Ho\u0302pital du Bocage, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gambert","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"},{"name":"Institut Fe\u0301de\u0301ratif de Recherche 100 (E.F., P.G.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Verge\u0300s","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 866-Universite\u0301 de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculte\u0301 de Me\u0301decine, Dijon F-21000, France"},{"name":"Department of Endocrinology and Metabolic Diseases (J.-M.P., B.V.), Centre Hospitalier Universitaire Dijon, Ho\u0302pital du Bocage, Dijon F-21000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613143778400_R1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1373\/clinchem.2007.101923","article-title":"Laboratory assessment of HDL heterogeneity and function.","volume":"54","author":"Movva","year":"2008","journal-title":"Clin Chem"},{"key":"2020071613143778400_R2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.ATV.8.6.737","article-title":"High density lipoprotein cholesterol and mortality. 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