{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:50:23Z","timestamp":1789512623441,"version":"build-2803163510"},"reference-count":14,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"DOI":"10.1210\/jc.2009-2078","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T21:10:10Z","timestamp":1269551410000},"page":"2841-2844","source":"Crossref","is-referenced-by-count":14,"title":["Free \u03b1-Subunit Is the Most Sensitive Marker of Gonadotropin Recovery after Treatment of Central Precocious Puberty with the Histrelin Implant"],"prefix":"10.1210","volume":"95","author":[{"given":"Harry J.","family":"Hirsch","sequence":"first","affiliation":[{"name":"Department of Pediatrics (H.J.H.), Shaare Zedek Medical Center, 91031 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Lahlou","sequence":"additional","affiliation":[{"name":"Hormonology and Metabolic Diseases Unit (N.L.), Centre Hospitalier Universitaire Cochin-Saint Vincent de Paul, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gillis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Endocrinology Clinic (D.G.), Hadassah University Hospital, Ein-Kerem, 91120 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Strich","sequence":"additional","affiliation":[{"name":"Specialty Pediatric Clinics (D.S.), Endocrinology and Diabetes, Clalit Health Service, 91010 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyamina","family":"Rosenberg-Hagen","sequence":"additional","affiliation":[{"name":"Plastic Surgery Center (B.R.-H.), Misgav Ladach Hospital, 93190 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Chertin","sequence":"additional","affiliation":[{"name":"Department of Urology (B.C., A.F.), Shaare Zedek Medical Center, 91031 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amicur","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Urology (B.C., A.F.), Shaare Zedek Medical Center, 91031 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadassa","family":"Hartman","sequence":"additional","affiliation":[{"name":"Institute of Hormone Research and Ben Gurion University of the Negev (H.H., I.M.S.), 92548 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving M.","family":"Spitz","sequence":"additional","affiliation":[{"name":"Institute of Hormone Research and Ben Gurion University of the Negev (H.H., I.M.S.), 92548 Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114052788300_R1","first-page":"346","article-title":"Gonadotropin-releasing hormone testing in pediatrics","author":"Roger","year":"1996","journal-title":"In: Ranke MB, ed. Diagnostics of endocrine function in children and adolescents. Heidelberg, Germany: Johann Ambriosius Barth Verlag;"},{"key":"key\n\t\t\t\t2019041114052788300_R2","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1210\/endo.136.7.7789305","article-title":"Expression of gonadotropin-releasing hormone (GnRH) receptor gene is altered by GnRH agonist desensitization in a manner similar to that of gonadotropin \u03b2-subunit genes in normal and castrated rat pituitary","volume":"136","author":"Lerrant","year":"1995","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041114052788300_R3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/jcem-65-5-946","article-title":"Gonadotropin and \u03b1-subunit secretion during long term pituitary suppression by d-Trp6-luteinizing hormone-releasing hormone microcapsules as treatment of precocious puberty","volume":"65","author":"Lahlou","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114052788300_R4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1515\/JPEM.2000.13.S1.723","article-title":"Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics","volume":"13","author":"Lahlou","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114052788300_R5","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1210\/jc.2001-020243","article-title":"Treatment of central precocious puberty by subcutaneous injections of leuprorelin 3-month depot (11.25 mg)","volume":"87","author":"Carel","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114052788300_R6","doi-asserted-by":"crossref","first-page":"e798","DOI":"10.1542\/peds.2005-0538","article-title":"The histrelin implant: a novel treatment for central precocious puberty","volume":"116","author":"Hirsch","year":"2005","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2019041114052788300_R7","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1210\/jc.2006-2479","article-title":"Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial","volume":"92","author":"Eugster","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114052788300_R8","doi-asserted-by":"crossref","DOI":"10.1186\/1687-9856-2009-812517","article-title":"Results of a second year of therapy with the 12-month histrelin implant for the treatment of central precocious puberty","author":"Rahhal","year":"2009","journal-title":"Int J Pediatr Endocrinol"},{"key":"key\n\t\t\t\t2019041114052788300_R9","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0022-5347(05)67816-0","article-title":"An implant releasing the gonadotropin hormone-releasing hormone agonist histrelin maintains medical castration for up to 30 months in metastatic prostate cancer","volume":"163","author":"Chertin","year":"2000","journal-title":"J Urol"},{"key":"key\n\t\t\t\t2019041114052788300_R10","article-title":"Hydron implant for continuous treatment of prostate cancer: twelve months and beyond","author":"Kuzma","year":"1999"},{"key":"key\n\t\t\t\t2019041114052788300_R11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0090-4295(01)01293-6","article-title":"Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin","volume":"58","author":"Schlegel","year":"2001","journal-title":"Urology"},{"key":"key\n\t\t\t\t2019041114052788300_R12","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2019041114052788300_R13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1210\/edrv-2-2-186","article-title":"Gonadotropin-releasing hormone receptors: characterization, physiological regulation, and relationship to reproductive function","volume":"2","author":"Clayton","year":"1981","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114052788300_R14","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1542\/peds.110.3.e30","article-title":"Serum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy","volume":"110","author":"Nafstad","year":"2002","journal-title":"Pediatrics"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/95\/6\/2841\/9068487\/jcem2841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T12:50:00Z","timestamp":1558961400000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/95\/6\/2841\/2598587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-2078","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}