{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:58:53Z","timestamp":1778216333601,"version":"3.51.4"},"reference-count":40,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"DOI":"10.1210\/jc.2009-2289","type":"journal-article","created":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T20:50:06Z","timestamp":1264193406000},"page":"1238-1246","source":"Crossref","is-referenced-by-count":45,"title":["\u03b2-Cell Secretory Capacity and Demand in Recipients of Islet, Pancreas, and Kidney Transplants"],"prefix":"10.1210","volume":"95","author":[{"given":"Michael R.","family":"Rickels","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism (M.R.R., R.M., K.L.T.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism (M.R.R., R.M., K.L.T.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Teff","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism (M.R.R., R.M., K.L.T.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149"},{"name":"Monell Chemical Senses Center (K.L.T.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Naji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation (A.N.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113480048300_R1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1056\/NEJMoa061267","article-title":"International trial of the Edmonton protocol for islet transplantation","volume":"355","author":"Shapiro","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113480048300_R2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2337\/diabetes.54.1.100","article-title":"\u03b2-Cell function following human islet transplantation for type 1 diabetes","volume":"54","author":"Rickels","year":"2005","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R3","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1073\/pnas.0608141103","article-title":"Correlation between \u03b2 cell mass and glycemic control in type 1 diabetic recipients of islet cell graft","volume":"103","author":"Keymeulen","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl 4","key":"key\n\t\t\t\t2019041113480048300_R4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1463-1326.2008.00945.x","article-title":"An examination of \u03b2-cell function measures and their potential use for estimating \u03b2-cell mass","volume":"10","author":"Kahn","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"key\n\t\t\t\t2019041113480048300_R5","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1111\/j.1600-6143.2009.02844.x","article-title":"Positron emission tomography in clinical islet transplantation","volume":"9","author":"Eriksson","year":"2009","journal-title":"Am J Transplant"},{"key":"key\n\t\t\t\t2019041113480048300_R6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00007890-200202150-00007","article-title":"Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets","volume":"73","author":"Paty","year":"2002","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00007890-199908150-00012","article-title":"Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation","volume":"68","author":"Drachenberg","year":"1999","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2337\/diacare.25.3.583","article-title":"Posttransplantation diabetes","volume":"25","author":"Montori","year":"2002","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113480048300_R9","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced exposure to calcineurin inhibitors in renal transplantation","volume":"357","author":"Ekberg","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113480048300_R10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2337\/diab.43.4.593","article-title":"Diminished insulin secretory reserve in diabetic pancreas transplant and nondiabetic kidney transplant recipients","volume":"43","author":"Teuscher","year":"1994","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R11","first-page":"3972","article-title":"Pancreatic endocrine function in recipients of segmental and whole pancreas transplantation","volume":"81","author":"Christiansen","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113480048300_R12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/TP.0b013e3181928a1c","article-title":"Functional \u03b2-cell mass and insulin sensitivity is decreased in insulin-independent pancreas-kidney recipients","volume":"87","author":"Gillard","year":"2009","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R13","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/00007890-199911270-00017","article-title":"The effects of maintenance doses of FK506 versus cyclosporin A on glucose and lipid metabolism after orthotopic liver transplantation","volume":"68","author":"Fernandez","year":"1999","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2337\/diab.39.5.534","article-title":"Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type 1 diabetic recipients","volume":"39","author":"Diem","year":"1990","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000180518","article-title":"Insulin and kidney","volume":"15","author":"Rubenstein","year":"1975","journal-title":"Nephron"},{"key":"key\n\t\t\t\t2019041113480048300_R16","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.2337\/db06-0069","article-title":"Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver","volume":"55","author":"Meier","year":"2006","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R17","first-page":"E405","article-title":"Adaptation of B and A cell function during prolonged glucose infusion in human subjects","volume":"246","author":"Ward","year":"1984","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113480048300_R18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1172\/JCI115779","article-title":"Effects of hemipancreatectomy on pancreatic \u03b1 and \u03b2 cell function in healthy human donors","volume":"89","author":"Seaquist","year":"1992","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113480048300_R19","doi-asserted-by":"crossref","first-page":"E557","DOI":"10.1152\/ajpendo.00325.2002","article-title":"Improved \u03b2-cell function after standardized weight reduction in severely obese subjects","volume":"284","author":"Guldstrand","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113480048300_R20","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1172\/JCI108047","article-title":"Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood","volume":"55","author":"Horwitz","year":"1975","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113480048300_R21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113480048300_R22","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1097\/01.TP.0000081043.23751.81","article-title":"Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?","volume":"76","author":"Desai","year":"2003","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R23","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1073\/pnas.91.20.9253","article-title":"Major species differences between humans and rodents in the susceptibility to pancreatic \u03b2-cell injury","volume":"91","author":"Eizirik","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113480048300_R24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2337\/diab.38.1.58","article-title":"Intravenous glucose tolerance and pancreatic islet \u03b2-cell function in patients with multiple sclerosis during 2-yr treatment with cyclosporine","volume":"38","author":"Robertson","year":"1989","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00007890-199704150-00013","article-title":"A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation","volume":"63","author":"Pirsch","year":"1997","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJMoa050085","article-title":"Costimulation blockade with belatacept in renal transplantation","volume":"353","author":"Vincenti","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113480048300_R27","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1097\/01.ASN.0000145435.80005.1E","article-title":"Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal","volume":"15","author":"Midtvedt","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2019041113480048300_R28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/diabetes.54.2.424","article-title":"Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets","volume":"54","author":"Hui","year":"2005","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R29","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/01.tp.0000255679.81792.dd","article-title":"In vivo and in vitro effect of sirolimus on insulin secretion","volume":"83","author":"Marcelli-Tourvieille","year":"2007","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/en.2003-1070","article-title":"Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation","volume":"145","author":"Lopez-Talavera","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113480048300_R31","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2337\/db06-1016","article-title":"The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man","volume":"56","author":"Krebs","year":"2007","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113480048300_R32","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(99)03882-9","article-title":"Sirolimus-tacrolimus combination immunosuppression","volume":"355","author":"McAlister","year":"2000","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113480048300_R33","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1600-6143.2005.00885.x","article-title":"A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients. An interim analysis","volume":"5","author":"Kandaswamy","year":"2005","journal-title":"Am J Transplant"},{"key":"key\n\t\t\t\t2019041113480048300_R34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.transproceed.2005.12.037","article-title":"Proinsulinemia in simultaneous pancreas and kidney transplant recipients","volume":"38","author":"Bak","year":"2006","journal-title":"Transplant Proc"},{"key":"key\n\t\t\t\t2019041113480048300_R35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1172\/JCI118435","article-title":"Hyperproinsulinemia is associated with increased \u03b2 cell demand after hemipancreatectomy in humans","volume":"97","author":"Seaquist","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113480048300_R36","first-page":"1386","article-title":"Prolonged exposure of human \u03b2-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine","volume":"84","author":"Hostens","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113480048300_R37","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/01.TP.0000134973.77057.39","article-title":"Cross-sectional and prospective association between proinsulin secretion and graft function after clinical islet transplantation","volume":"78","author":"McDonald","year":"2004","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R38","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/01.TP.0000161221.17627.8A","article-title":"Calcineurin inhibitor- and steroid-free immunosuppression in pancreas-kidney and solitary pancreas transplantation","volume":"79","author":"Gruessner","year":"2005","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113480048300_R39","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1432-2277.2006.00388.x","article-title":"Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation","volume":"19","author":"Barth","year":"2006","journal-title":"Transpl Int"},{"key":"key\n\t\t\t\t2019041113480048300_R40","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/01.tp.0000232688.76018.19","article-title":"High rejection rate during calcineurin inhibitor-free and early steroid withdrawal immunosuppression in renal transplantation","volume":"82","author":"Gelens","year":"2006","journal-title":"Transplantation"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/95\/3\/1238\/9067114\/jcem1238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T05:23:39Z","timestamp":1558761819000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/95\/3\/1238\/2597086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-2289","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,1]]}}}