{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:20:25Z","timestamp":1790626825597,"version":"4.1.0"},"reference-count":9,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"DOI":"10.1210\/jc.2009-2463","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T03:29:33Z","timestamp":1269487773000},"page":"2281-2285","source":"Crossref","is-referenced-by-count":57,"title":["A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain"],"prefix":"10.1210","volume":"95","author":[{"given":"Nancy","family":"Nader","sequence":"first","affiliation":[{"name":"Unit on Molecular Hormone Action (N.N., T.K.), Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert E.","family":"Bachrach","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology\/Diabetes (B.E.B., S.G., A.P., R.L.), University of Missouri Children\u2019s Hospital, Columbia Missouri 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell E.","family":"Hurt","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and Bioinformatics and Computational Biosciences Branch (D.E.H.), Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Gajula","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology\/Diabetes (B.E.B., S.G., A.P., R.L.), University of Missouri Children\u2019s Hospital, Columbia Missouri 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology\/Diabetes (B.E.B., S.G., A.P., R.L.), University of Missouri Children\u2019s Hospital, Columbia Missouri 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lescher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology\/Diabetes (B.E.B., S.G., A.P., R.L.), University of Missouri Children\u2019s Hospital, Columbia Missouri 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoshige","family":"Kino","sequence":"additional","affiliation":[{"name":"Unit on Molecular Hormone Action (N.N., T.K.), Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116123035700_R1","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1210\/jc.2008-0040","article-title":"Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder","volume":"93","author":"Charmandari","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116123035700_R2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-980196","article-title":"Novel causes of generalized glucocorticoid resistance","volume":"39","author":"Charmandari","year":"2007","journal-title":"Horm Metab Res"},{"key":"2019041116123035700_R3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bse0400137","article-title":"Glucocorticoid and mineralocorticoid receptors and associated diseases","volume":"40","author":"Kino","year":"2004","journal-title":"Essays Biochem"},{"key":"2019041116123035700_R4","doi-asserted-by":"crossref","first-page":"pe48","DOI":"10.1126\/stke.3042005pe48","article-title":"Intracellular glucocorticoid signaling: a formerly simple system turns stochastic","volume":"2005","author":"Chrousos","year":"2005","journal-title":"Sci STKE"},{"key":"2019041116123035700_R5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0960-0760(03)00218-8","article-title":"Tissue glucocorticoid resistance\/hypersensitivity syndromes","volume":"85","author":"Kino","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041116123035700_R6","first-page":"321","article-title":"Nuclear receptor coregulators: cellular and molecular biology","volume":"20","author":"McKenna","year":"1999","journal-title":"Endocr Rev"},{"key":"2019041116123035700_R7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(02)00817-6","article-title":"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition","volume":"110","author":"Bledsoe","year":"2002","journal-title":"Cell"},{"key":"2019041116123035700_R8","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1007\/s00018-009-0098-z","article-title":"Human glucocorticoid receptor isoform \u03b2: recent understanding of its potential implications in physiology and pathophysiology","volume":"66","author":"Kino","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"2019041116123035700_R9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000084093","article-title":"Puberty and fertility in congenital adrenal hyperplasia","volume":"8","author":"Otten","year":"2005","journal-title":"Endocr Dev"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/95\/5\/2281\/9068501\/jcem2281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T06:11:17Z","timestamp":1685513477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/95\/5\/2281\/2597093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,1]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-2463","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,1]]}}}