{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:26:54Z","timestamp":1790864814673,"version":"4.1.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"DOI":"10.1210\/jc.2009-2570","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T01:54:07Z","timestamp":1273715647000},"page":"3648-3656","source":"Crossref","is-referenced-by-count":122,"title":["Cardiovascular Risk Factors in Patients with Uncontrolled and Long-Term Acromegaly: Comparison with Matched Data from the General Population and the Effect of Disease Control"],"prefix":"10.1210","volume":"95","author":[{"given":"Christian","family":"Berg","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Petersenn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard L.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Buchfelder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (M.B.), University of Erlangen-Nuremberg, 91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Droste","sequence":"additional","affiliation":[{"name":"Department of Endocrinologist (M.D.), 26122 Oldenburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nter K.","family":"Stalla","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (G.K.S.), Max-Planck Institute of Psychiatry, 80804 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Strasburger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (C.J.S.), Charite Campus Mitte, 10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Roggenbuck","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (U.R., N.L., S.M., K.-H.J.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (U.R., N.L., S.M., K.-H.J.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Moebus","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (U.R., N.L., S.M., K.-H.J.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"},{"name":"Department of Cardiology (S.M., R.E.), West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Jo\u0308ckel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (U.R., N.L., S.M., K.-H.J.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Mo\u0308hlenkamp","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (U.R., N.L., S.M., K.-H.J.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"},{"name":"Department of Cardiology (S.M., R.E.), West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.M., R.E.), West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Saller","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"},{"name":"Pfizer Endocrine Care Europe (B.S.), Tadworth KT20 7NS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Division of Laboratory Research (C.B., S.P., H.L., B.L.H., B.S., K.M.); West-German Heart Centre Essen, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Investigative Group of the Heinz Nixdorf Recall Study the German Pegvisomant Observational Study Board and Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113422065800_R1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJM199004053221405","article-title":"Acromegaly.","volume":"322","author":"Melmed","year":"1990","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113422065800_R2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","article-title":"Systemic complications of acromegaly: epidemiology, pathogenesis, and management.","volume":"25","author":"Colao","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113422065800_R3","first-page":"2730","article-title":"Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group.","volume":"83","author":"Orme","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2265.2009.03555.x","article-title":"Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients.","volume":"71","author":"Sievers","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113422065800_R5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/archinte.1938.00180100014002","article-title":"The heart in acromegaly.","volume":"61","author":"Courville","year":"1938","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113422065800_R6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/jcem-2-8-477","article-title":"Acromegaly: a consideration of its course and treatment. Report of four cases with autopsies.","volume":"2","author":"Goldberg","year":"1942","journal-title":"J Clin Endocrinol"},{"key":"key\n\t\t\t\t2019041113422065800_R7","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.7326\/0003-4819-34-6-1445","article-title":"Acromegaly and heart: a clinical and pathologic study.","volume":"34","author":"Hejtmancik","year":"1950","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113422065800_R8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0002-8703(80)90277-X","article-title":"Pathology of the heart in acromegaly: anatomic findings in 27 autopsied patients.","volume":"100","author":"Lie","year":"1980","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t2019041113422065800_R9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2265.2001.01281.x","article-title":"Characterization of premature atherosclerosis of carotid arteries in acromegalic patients.","volume":"54","author":"Otsuki","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113422065800_R10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJMcp023197","article-title":"Clinical practice. Selecting asymptomatic patients for coronary computed tomographic exercise testing.","volume":"349","author":"Greenland","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113422065800_R11","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1210\/jc.2005-2857","article-title":"Acromegaly and coronary disease: an integrated evaluation of conventional coronary risk factors and coronary calcifications detected by computed tomography.","volume":"91","author":"Cannavo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R12","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1210\/jc.2007-1213","article-title":"Risk factors for development of coronary heart disease in patients with acromegaly: a five-year prospective study.","volume":"92","author":"Bogazzi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/eje.1.02312","article-title":"Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study.","volume":"156","author":"Schreiber","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113422065800_R14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1067\/mhj.2002.123579","article-title":"Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study. Risk Factors, Evaluation of Coronary Calcification and Lifestyle.","volume":"144","author":"Schmermund","year":"2002","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t2019041113422065800_R15","first-page":"108","article-title":"[Assessment of the natural history of coronary artery calcification and identification of its determinants","volume":"32","author":"Mo\u0308hlenkamp","year":"2007","journal-title":"Rationale of the 2nd part of the Heinz Nixdorf Recall Study]. Herz"},{"key":"key\n\t\t\t\t2019041113422065800_R16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1751-7141.2008.00019.x","article-title":"Appropriateness of cholesterol management in primary care by sex and level of cardiovascular risk.","volume":"12","author":"Barham","year":"2009","journal-title":"Prev Cardiol"},{"key":"key\n\t\t\t\t2019041113422065800_R17","first-page":"289","article-title":"Risk assessment","volume":"353","author":"Anderson","year":"1991","journal-title":"End of an era. Nature"},{"key":"key\n\t\t\t\t2019041113422065800_R18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113422065800_R19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1210\/jc.2008-1546","article-title":"Impact of somatostatin analogs versus surgery on glucose metabolism in acromegaly: results of a 5-year observational, open, prospective study.","volume":"94","author":"Colao","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/s-0029-1214386","article-title":"Impact of disease duration on coronary calcification in patients with acromegaly.","volume":"117","author":"Herrmann","year":"2009","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t2019041113422065800_R21","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1210\/jc.2005-1616","article-title":"Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly.","volume":"91","author":"Jenkins","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism.","volume":"336","author":"Rose\u0301n","year":"1990","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113422065800_R23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113422065800_R24","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1210\/jc.2003-031584","article-title":"Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly.","volume":"89","author":"Ayuk","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R25","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1210\/jc.2004-1381","article-title":"A nationwide survey of mortality in acromegaly.","volume":"90","author":"Kauppinen-Ma\u0308kelin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113422065800_R26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1210\/edrv-15-5-555","article-title":"Growth hormone and the heart.","volume":"15","author":"Sacca\u0300","year":"1994","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113422065800_R27","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1097\/00004872-199917121-00028","article-title":"Blood-pressure independent cardiac hypertrophy in acromegalic patients.","volume":"17","author":"Ciulla","year":"1999","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041113422065800_R28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1210\/er.2003-0009","article-title":"Cardiovascular function in acromegaly.","volume":"24","author":"Clayton","year":"2003","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113422065800_R29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.2001.01218.x","article-title":"Growth hormone and the heart.","volume":"54","author":"Colao","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113422065800_R30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1530\/eje.0.1460303","article-title":"Effect of a six-month treatment with lanreotide on cardiovascular risk factors and arterial intima-media thickness in patients with acromegaly.","volume":"146","author":"Colao","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113422065800_R31","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/eurheartj\/ehm316","article-title":"European guidelines on cardiovascular disease prevention in clinical practice: executive summary.","volume":"28","author":"Graham","year":"2007","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041113422065800_R32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1541-9215.2007.06350.x","article-title":"The Framingham Risk Score: an appraisal of its benefits and limitations.","volume":"5","author":"Hemann","year":"2007","journal-title":"Am Heart Hosp J"},{"key":"key\n\t\t\t\t2019041113422065800_R33","first-page":"527","article-title":"[Cardiovascular risk by Framingham and SCORE in patients 40\u201365 years old].","volume":"126","author":"Gonzalez","year":"2006","journal-title":"Med Clin (Barc)"},{"key":"key\n\t\t\t\t2019041113422065800_R34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-2796.2003.01137.x","article-title":"Prediction of coronary heart disease: a comparison between the Copenhagen risk score and the Framingham risk score applied to a Dutch population.","volume":"253","author":"Visser","year":"2003","journal-title":"J Intern Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/95\/8\/3648\/9066879\/jcem3648.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T21:12:24Z","timestamp":1740085944000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/95\/8\/3648\/2596547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,1]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-2570","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,1]]}}}