{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:55:43Z","timestamp":1791755743738,"version":"4.3.4"},"reference-count":36,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>Context: There is limited information on the association between sex hormones and bone loss in older men.<\/jats:p><jats:p>Objective: Our objective was to determine the longitudinal association between sex steroid hormones and bone mineral density (BMD).<\/jats:p><jats:p>Design and Setting: We conducted a prospective study of 5995 men aged at least 65 yr old at six U.S. clinical centers.<\/jats:p><jats:p>Participants: Sex steroid hormones were measured in a random sample of 1602 men. After exclusions, 1238 men were included in cross-sectional analyses and 969 in longitudinal analyses. Baseline sex hormones were measured using liquid chromatography-mass spectrometry. Bioavailable (Bio) estradiol (BioE2) and testosterone (BioT) were calculated from mass action equations. SHBG was measured using chemiluminescent substrate.<\/jats:p><jats:p>Main Outcome Measures: BMD of the total hip, measured at baseline and once or twice afterward over 4.6 yr of follow-up, was evaluated.<\/jats:p><jats:p>Results: The annualized percent change in hip BMD increased with decreasing BioE2 (P trend = 0.03). Men with the lowest BioE2 (&amp;lt;39.7 pmol\/liter) compared with the highest BioE2 (\u226566.0 pmol\/liter) experienced 38% faster rate of BMD loss (P &amp;lt; 0.05). There was no association between BioT and hip BMD loss. Men with lowest BioE2, lowest BioT, and highest SHBG experienced a 3-fold faster rate of BMD loss compared with men with higher levels (P = 0.02). A threshold effect of SHBG was observed; the rate of hip BMD loss increased in men with SHBG of 49\u201360 nm.<\/jats:p><jats:p>Conclusions: Low BioE2 and high SHBG levels were associated with lower BMD and faster hip BMD loss. The combination of low BioE2, low BioT, and high SHBG was associated with significantly faster rates of BMD loss.<\/jats:p>","DOI":"10.1210\/jc.2009-2635","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T01:21:23Z","timestamp":1276737683000},"page":"4314-4323","source":"Crossref","is-referenced-by-count":108,"title":["Sex Steroid Hormones in Older Men: Longitudinal Associations with 4.5-Year Change in Hip Bone Mineral Density\u2014The Osteoporotic Fractures in Men Study"],"prefix":"10.1210","volume":"95","author":[{"given":"Jane A.","family":"Cauley","sequence":"first","affiliation":[{"name":"University of Pittsburgh (J.A.C.), Pittsburgh, Pennsylvania 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Ewing","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (S.K.E., D.C.B.), San Francisco, California 94107;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center (B.C.T., H.A.F., K.E.E.) and University of Minnesota, Minneapolis, Minnesota 55417;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Fink","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center (B.C.T., H.A.F., K.E.E.) and University of Minnesota, Minneapolis, Minnesota 55417;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center (B.C.T., H.A.F., K.E.E.) and University of Minnesota, Minneapolis, Minnesota 55417;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Bauer","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (S.K.E., D.C.B.), San Francisco, California 94107;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Barrett-Connor","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center (B.C.T., H.A.F., K.E.E.) and University of Minnesota, Minneapolis, Minnesota 55417;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Marshall","sequence":"additional","affiliation":[{"name":"University of California at San Diego (E.B.C.), San Diego, California 92123; and Oregon Health and Sciences University (L.M., E.S.O.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Orwoll","sequence":"additional","affiliation":[{"name":"University of California at San Diego (E.B.C.), San Diego, California 92123; and Oregon Health and Sciences University (L.M., E.S.O.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Osteoporotic Fractures in Men Study (MrOS) 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