{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:07:20Z","timestamp":1791446840153,"version":"4.3.3"},"reference-count":57,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood.<\/jats:p><jats:p>Objective: Our objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men.<\/jats:p><jats:p>Design, Setting, and Participants: We conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 \u00b1 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectional and longitudinal analyses of mobility limitation and physical performance were performed with continuous (per sd) and dichotomized [low TT and free testosterone (FT) and high SHBG vs. normal] hormone levels.<\/jats:p><jats:p>Main Outcome Measures: Self-reported mobility limitation, subjective health, usual walking speed, and grip strength were assessed at examinations 7 and 8. Short physical performance battery was performed at examination 7.<\/jats:p><jats:p>Results: Higher continuous FT was positively associated with short physical performance battery score (\u03b2 = 0.13; P = 0.008), usual walking speed (\u03b2 = 0.02; P = 0.048), and lower risk of poor subjective health [odds ratio (OR) = 0.72; P = 0.01]. In prospective analysis, 1 sd increase in baseline FT was associated with lower risk of developing mobility limitation (OR = 0.78; 95% confidence interval = 0.62\u20130.97) and progression of mobility limitation (OR = 0.75; 95% confidence interval = 0.60\u20130.93). Men with low baseline FT had 57% higher odds of reporting incident mobility limitation (P = 0.03) and 68% higher odds of worsening of mobility limitation (P = 0.007).<\/jats:p><jats:p>Conclusions: Lower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men. Whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials.<\/jats:p>","DOI":"10.1210\/jc.2009-2680","type":"journal-article","created":{"date-parts":[[2010,4,10]],"date-time":"2010-04-10T00:35:01Z","timestamp":1270859701000},"page":"2790-2799","source":"Crossref","is-referenced-by-count":128,"title":["Free Testosterone Levels Are Associated with Mobility Limitation and Physical Performance in Community-Dwelling Men: The Framingham Offspring Study"],"prefix":"10.1210","volume":"95","author":[{"given":"Joanne B.","family":"Krasnoff","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Sections of Endocrinology, Diabetes, and Nutrition (J.B.K., S.Ba., J.U., A.Z., A.C., S.Bh.), Boston University, Boston, Massachusetts 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehzad","family":"Basaria","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Sections of 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