{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:39:55Z","timestamp":1774287595943,"version":"3.50.1"},"reference-count":36,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:p>Context: The GHRH plus arginine (GHRH+Arg) test is a promising alternative to the insulin tolerance test (ITT) for diagnosis of adult GH deficiency (AGHD).<\/jats:p>\n               <jats:p>Objectives: The objectives of the study were to validate the GHRH+Arg test for diagnosis of AGHD, using the ITT as comparator and a GH assay calibrated according to recent international recommendations, and to study the repeatability and tolerance of both tests.<\/jats:p>\n               <jats:p>Design: This was a multicenter, randomized, open-label, phase III study.<\/jats:p>\n               <jats:p>Setting: The study was conducted at 10 French university hospitals.<\/jats:p>\n               <jats:p>Subjects: Sixty-nine subjects (38 and 15 with high and low probability of GH deficiency, respectively, and 16 healthy controls) were randomized: 35 to the GHRH+Arg-GHRH+Arg-ITT test sequence and 34 to the ITT-ITT-GHRH+Arg test sequence.<\/jats:p>\n               <jats:p>Interventions: Each subject underwent three tests of GH secretion separated by 24 h or more.<\/jats:p>\n               <jats:p>Main Outcome Measures: The primary variable used for response assessments was serum peak GH response. Test results were compared with the final AGHD diagnosis.<\/jats:p>\n               <jats:p>Results: Peak GH responses in the two tests were strongly correlated. A cutoff value of 7.89 \u03bcg\/liter for GHRH+Arg corresponding to 3 \u03bcg\/liter for ITT was calculated. The cutoff value leading to 95% specificity with the GHRH+Arg test was measured at about 3.67 \u03bcg\/liter (sensitivity 79.0%). Intermethod agreement and repeatability were high. Both tests were well tolerated. A preference for the GHRH+Arg test was expressed by 74% of subjects.<\/jats:p>\n               <jats:p>Conclusions: The GHRH+Arg test demonstrated good accuracy and repeatability, was at least as sensitive as the ITT, and was associated with better subject acceptability. The GHRH+Arg test represents a good alternative to the ITT for the diagnosis of AGHD.<\/jats:p>","DOI":"10.1210\/jc.2010-0295","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T02:12:47Z","timestamp":1274321567000},"page":"3684-3692","source":"Crossref","is-referenced-by-count":20,"title":["Comparative Validation of the Growth Hormone-Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency Using a Growth Hormone Assay Conforming to Recent International 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