{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:01:26Z","timestamp":1768982486985,"version":"3.49.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"DOI":"10.1210\/jc.2010-0501","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T21:58:28Z","timestamp":1293055108000},"page":"755-765","source":"Crossref","is-referenced-by-count":44,"title":["Activin-A and Myostatin Response and Steroid Regulation in Human Myometrium: Disruption of Their Signalling in Uterine Fibroid"],"prefix":"10.1210","volume":"96","author":[{"given":"Pasquapina","family":"Ciarmela","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology and Innovative Therapies (P.Ci., M.S.I., M.C.), Faculty of Medicine, Polytechnic University of Marche, 60020 Ancona, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrrico","family":"Bloise","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (E.B., P.Ca., F.D.P., F.M.S., F.P.), Department of Pediatrics, Obstetrics, and Reproductive Medicine; University of Siena, Siena 53100, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Gray","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology (P.C.G., W.V.), The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Carrarelli","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (E.B., P.Ca., F.D.P., F.M.S., F.P.), Department of Pediatrics, Obstetrics, and Reproductive Medicine; University of Siena, Siena 53100, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Soriful","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology and Innovative Therapies (P.Ci., M.S.I., M.C.), Faculty of Medicine, Polytechnic University of Marche, 60020 Ancona, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"De Pascalis","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (E.B., P.Ca., F.D.P., F.M.S., F.P.), Department of Pediatrics, Obstetrics, and Reproductive Medicine; University of Siena, Siena 53100, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiberto Maria","family":"Severi","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (E.B., P.Ca., F.D.P., F.M.S., F.P.), Department of Pediatrics, Obstetrics, and Reproductive Medicine; University of Siena, Siena 53100, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wylie","family":"Vale","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology (P.C.G., W.V.), The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Castellucci","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology and Innovative Therapies (P.Ci., M.S.I., M.C.), Faculty of Medicine, Polytechnic University of Marche, 60020 Ancona, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Petraglia","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (E.B., P.Ca., F.D.P., F.M.S., F.P.), Department of Pediatrics, Obstetrics, and Reproductive Medicine; University of Siena, Siena 53100, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113533017400_B1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tem.2005.01.003","article-title":"Antagonists of activin signaling: mechanisms and potential biological applications.","volume":"16","author":"Harrison","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113533017400_B2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-\u03b2 superfamily member.","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113533017400_B3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(91)90549-E","article-title":"Expression cloning of an activin receptor, a predicted transmembrane serine kinase.","volume":"65","author":"Mathews","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113533017400_B4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1128\/MCB.16.3.1066","article-title":"Activation of signalling by the activin receptor complex.","volume":"16","author":"Attisano","year":"1996","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041113533017400_B5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: transcriptional activators of TGF-\u03b2 responses.","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113533017400_B6","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1128\/MCB.23.20.7230-7242.2003","article-title":"Myostatin signals through a transforming growth factor \u03b2-like signaling pathway to block adipogenesis.","volume":"23","author":"Rebbapragada","year":"2003","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041113533017400_B7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1210\/endo.142.3.8028","article-title":"Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-\u03b2 signaling in anterior pituitary cells.","volume":"142","author":"Bilezikjian","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cyto.2004.03.007","article-title":"Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism.","volume":"26","author":"Zhu","year":"2004","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t2019041113533017400_B9","doi-asserted-by":"crossref","first-page":"40735","DOI":"10.1074\/jbc.M206379200","article-title":"The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.","volume":"277","author":"Hill","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113533017400_B10","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1038\/sj.onc.1201807","article-title":"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.","volume":"16","author":"Hayette","year":"1998","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019041113533017400_B11","doi-asserted-by":"crossref","first-page":"40788","DOI":"10.1074\/jbc.M006114200","article-title":"Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-\u03b2 family.","volume":"275","author":"Tsuchida","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113533017400_B12","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/j.1460-2075.1989.tb03605.x","article-title":"Molecular characterization of a gene of the \u2018EGF family\u2019 expressed in undifferentiated human NTERA2 teratocarcinoma cells.","volume":"8","author":"Ciccodicola","year":"1989","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019041113533017400_B13","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1073\/pnas.0531290100","article-title":"Cripto forms a complex with activin and type II activin receptors and can block activin signaling.","volume":"100","author":"Gray","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113533017400_B14","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1074\/jbc.M704960200","article-title":"Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal.","volume":"283","author":"Kelber","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113533017400_B15","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1128\/MCB.01168-06","article-title":"Cripto binds transforming growth factor \u03b2 (TGF-\u03b2) and inhibits TGF-\u03b2 signaling.","volume":"26","author":"Gray","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041113533017400_B16","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/en.2008-0880","article-title":"Presence, actions, and regulation of myostatin in rat uterus and myometrial cells.","volume":"150","author":"Ciarmela","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B17","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1210\/en.2007-0692","article-title":"Activin-A in myometrium: characterization of the actions on myometrial cells.","volume":"149","author":"Ciarmela","year":"2008","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1289\/ehp.5787","article-title":"Etiology and pathogenesis of uterine leiomyomas: a review.","volume":"111","author":"Flake","year":"2003","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t2019041113533017400_B19","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1126\/science.1112063","article-title":"Uterine fibroids: the elephant in the room.","volume":"308","author":"Walker","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041113533017400_B20","first-page":"1556","article-title":"Rodent model of reproductive tract leiomyomata. Clinical and pathological features.","volume":"146","author":"Everitt","year":"1995","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019041113533017400_B21","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1158\/1078-0432.CCR-06-1811","article-title":"Tumor-specific efficacy of transforming growth factor-\u03b2 RI inhibition in Eker rats.","volume":"13","author":"Laping","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019041113533017400_B22","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(03)00953-1","article-title":"Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology.","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113533017400_B23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0015-0282(03)00958-0","article-title":"Microarray analysis in fibroids: which gene list is the correct list?","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113533017400_B24","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1093\/hmg\/ddm043","article-title":"Genetic heterogeneity among uterine leiomyomata: insights into malignant progression.","volume":"16","author":"Hodge","year":"2007","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019041113533017400_B25","first-page":"4092","article-title":"Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment.","volume":"83","author":"Englund","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113533017400_B26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0039-128X(02)00111-3","article-title":"Expression of estrogen receptor \u03b1 and \u03b2 in myometrium of premenopausal and postmenopausal women.","volume":"68","author":"Sakaguchi","year":"2003","journal-title":"Steroids"},{"key":"key\n\t\t\t\t2019041113533017400_B27","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1210\/en.2005-0833","article-title":"Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3.","volume":"146","author":"Saito","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/BF03347022","article-title":"Human placenta and fetal membranes express follistatin-related gene mRNA and protein.","volume":"26","author":"Ciarmela","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113533017400_B29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2003.12.019","article-title":"Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide.","volume":"218","author":"Florio","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113533017400_B30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/eje.0.1510251","article-title":"Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma.","volume":"151","author":"Ciarmela","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113533017400_B31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/1471-2407-9-320","article-title":"Differential expression of follistatin and FLRG in human breast proliferative disorders.","volume":"9","author":"Bloise","year":"2009","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t2019041113533017400_B32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/endo.135.1.8013382","article-title":"Human uterine tissue throughout the menstrual cycle expresses transforming growth factor-\u03b21 (TGF \u03b21), TGF \u03b22, TGF \u03b23, and TGF \u03b2 type II receptor messenger ribonucleic acid and protein and contains [125I]TGF \u03b21-binding sites.","volume":"135","author":"Chegini","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2003.08.007","article-title":"The expression of Smads and transforming growth factor \u03b2 receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy.","volume":"209","author":"Chegini","year":"2003","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113533017400_B34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1677\/erc.0.0070199","article-title":"The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.","volume":"7","author":"Saloman","year":"2000","journal-title":"Endocr Relat Cancer"},{"key":"key\n\t\t\t\t2019041113533017400_B35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/psc.1091","article-title":"Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor.","volume":"15","author":"Calvanese","year":"2009","journal-title":"J Pept Sci"},{"key":"key\n\t\t\t\t2019041113533017400_B36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/path.2083","article-title":"Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.","volume":"211","author":"Strizzi","year":"2007","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t2019041113533017400_B37","first-page":"1716","article-title":"Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro.","volume":"130","author":"Rossi","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113533017400_B38","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1095\/biolreprod50.5.1113","article-title":"Insulin-like growth factor I (IGF-I), IGF-I receptors, and IGF binding proteins 1\u20134 in human uterine tissue: tissue localization and IGF-I action in endometrial stromal and myometrial smooth muscle cells in vitro.","volume":"50","author":"Tang","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019041113533017400_B39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/molehr\/3.3.233","article-title":"The expression of transforming growth factor-\u03b2s and TGF-\u03b2 receptor mRNA and protein and the effect of TGF-\u03b2s on human myometrial smooth muscle cells in vitro.","volume":"3","author":"Tang","year":"1997","journal-title":"Mol Hum Reprod"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/96\/3\/755\/9068202\/jcem0755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T04:13:45Z","timestamp":1559880825000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/96\/3\/755\/2596820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,1]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2010-0501","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,1]]}}}