{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:41:40Z","timestamp":1790487700559,"version":"4.1.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>Introduction: It has been postulated that central adrenal insufficiency (CAI), resulting from hypothalamic dysfunction, may contribute to the increased unexplained death rates in Prader Willi syndrome (PWS). A study using the overnight metyrapone test reported a 60% prevalence of CAI in children with PWS. We used a low-dose Synacthen test to screen for CAI in children with PWS.<\/jats:p>\n               <jats:p>Methods: We studied 41 children with genetic diagnosis of PWS [20 males; mean age, 7.68 (\u00b15.23) yr] in five pediatric endocrinology centers in Australasia. All participants were randomly selected, and none had a history of Addisonian crisis. Ten of the cohort were receiving sex hormone therapy, 19 were receiving GH, and four were receiving T4. Their mean body mass index z-score was +1.48 (\u00b11.68). Baseline morning ACTH and cortisol levels were measured, followed by iv administration of 1 \u03bcg Synacthen. Post-Synacthen cortisol levels were measured at 30 min, and a cortisol level above 500 nmol\/liter was considered normal.<\/jats:p>\n               <jats:p>Results: The mean baseline ACTH and cortisol were 15 (\u00b114) ng\/liter and 223 (\u00b1116) nmol\/liter, respectively. The mean 30-min plasma cortisol was 690 (\u00b1114) nmol\/liter, and the average increase from baseline was 201%.<\/jats:p>\n               <jats:p>Conclusions: Our result suggests that CAI is rare in children with PWS.<\/jats:p>","DOI":"10.1210\/jc.2010-0647","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T01:45:00Z","timestamp":1283391900000},"page":"E464-E467","source":"Crossref","is-referenced-by-count":38,"title":["Normal Cortisol Response on Low-Dose Synacthen (1 \u03bcg) Test in Children with Prader Willi Syndrome"],"prefix":"10.1210","volume":"95","author":[{"given":"Ohn","family":"Nyunt","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (O.N., A.M.C., S.M.A., G.M.L., M.H.), Mater Children\u2019s Hospital, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Cotterill","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (O.N., A.M.C., S.M.A., G.M.L., M.H.), Mater Children\u2019s Hospital, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead M.","family":"Archbold","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (O.N., A.M.C., S.M.A., G.M.L., M.H.), Mater Children\u2019s Hospital, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry (J.Y.W.), Mater Health Services, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (O.N., A.M.C., S.M.A., G.M.L., M.H.), Mater Children\u2019s Hospital, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Verge","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (C.F.V.), Sydney Children\u2019s Hospital, Randwick and School of Women and Children\u2019s Health, University of New South Wales, Randwick, New South Wales 2052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Crock","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (P.A.C.), John Hunter Children\u2019s Hospital, New Castle, New South Wales 2305, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey R.","family":"Ambler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (G.R.A.), Children\u2019s Hospital at Westmead, Sydney, New South Wales 2145, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[{"name":"Liggins Institute (P.H.), University of Auckland, Auckland 1142, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes (O.N., A.M.C., S.M.A., G.M.L., M.H.), Mater Children\u2019s Hospital, Brisbane, Queensland 4101, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616561492100_R1","first-page":"1260","article-title":"Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach Myatonieartigem Zustand im Neugeborenenalter","volume":"86","author":"Prader","year":"1956","journal-title":"Schweiz Med 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