{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:47:11Z","timestamp":1790117231999,"version":"4.0.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"DOI":"10.1210\/jc.2010-1450","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T20:46:46Z","timestamp":1290026806000},"page":"412-421","source":"Crossref","is-referenced-by-count":128,"title":["Leiomyoma Simultaneously Impair Endometrial BMP-2-Mediated Decidualization and Anticoagulant Expression through Secretion of TGF-\u03b23"],"prefix":"10.1210","volume":"96","author":[{"given":"Donna C.","family":"Sinclair","sequence":"first","affiliation":[{"name":"Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mastroyannis","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114172343700_B1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2217\/WHE.09.29","article-title":"Management of uterine fibroids in the patient pursuing assisted reproductive technologies.","volume":"5","author":"Ezzati","year":"2009","journal-title":"Womens Health (Lond Engl)"},{"key":"key\n\t\t\t\t2019041114172343700_B2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ogc.2005.12.011","article-title":"Future directions in myoma research.","volume":"33","author":"Brahma","year":"2006","journal-title":"Obstet Gynecol Clin North Am"},{"key":"key\n\t\t\t\t2019041114172343700_B3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0015-0282(16)45789-4","article-title":"Uterine leiomyomata: etiology, symptomatology, and management.","volume":"36","author":"Buttram","year":"1981","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B4","first-page":"341","article-title":"Hysteroscopic myomectomy: long-term effects on menstrual pattern and fertility.","volume":"94","author":"Vercellini","year":"1999","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041114172343700_B5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0015-0282(16)47951-3","article-title":"Submucosal leiomyomas and infertility.","volume":"42","author":"Garcia","year":"1984","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(16)55128-0","article-title":"Myomectomy for fertility enhancement and preservation.","volume":"58","author":"Verkauf","year":"1992","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/er.2005-0018","article-title":"Endocrine regulation of HOX genes.","volume":"27","author":"Daftary","year":"2006","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114172343700_B8","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI1597","article-title":"HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.","volume":"101","author":"Taylor","year":"1998","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041114172343700_B9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0015-0282(02)03306-X","article-title":"Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression.","volume":"78","author":"Daftary","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/jc.2002-021072","article-title":"Regulation of HOXA10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome.","volume":"88","author":"Cermik","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114172343700_B11","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/humrep\/14.5.1328","article-title":"HOX gene expression is altered in the endometrium of women with endometriosis.","volume":"14","author":"Taylor","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041114172343700_B12","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.fertnstert.2008.03.029","article-title":"Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity.","volume":"93","author":"Rackow","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B13","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1128\/MCB.00342-07","article-title":"BMP-2 is critical for the murine uterine decidual response.","volume":"27","author":"Lee","year":"2007","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041114172343700_B14","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.98.3.1047","article-title":"Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.","volume":"98","author":"Paria","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114172343700_B15","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP-2 are nonviable and have defects in amnion\/chorion and cardiac development.","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t2019041114172343700_B16","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1095\/biolreprod63.6.1781","article-title":"Detection of multiple bone morphogenetic protein messenger ribonucleic acids and their signal transducer, Smad 1 during mouse decidualization.","volume":"63","author":"Ying","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019041114172343700_B17","doi-asserted-by":"crossref","first-page":"31725","DOI":"10.1074\/jbc.M704723200","article-title":"Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human.","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114172343700_B18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0010-7824(83)90106-3","article-title":"Occurrence of both urokinase and tissue plasminogen activator in human endometrium.","volume":"28","author":"Cassl\u00e9n","year":"1983","journal-title":"Contraception"},{"key":"key\n\t\t\t\t2019041114172343700_B19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/s-0037-1615846","article-title":"Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the uPA-uPAR-PAI-1 system.","volume":"82","author":"Blasi","year":"1999","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2019041114172343700_B20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/00016348109154110","article-title":"Fibrinolytic activity of human uterine fluid.","volume":"60","author":"Cassl\u00e9n","year":"1981","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041114172343700_B21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0268-9499(91)90007-Q","article-title":"Expression of cell membrane receptors for urokinase plasminogen activator (u-PA) in the human endometrium increases during the ovarian cycle.","volume":"5","author":"Casslen","year":"1991","journal-title":"Fibrinolysis"},{"key":"key\n\t\t\t\t2019041114172343700_B22","first-page":"621","article-title":"Progestin regulation of plasminogen activator inhibitor type-1 in primary cultures of endometrial stromal and decidual cells.","volume":"77","author":"Schatz","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114172343700_B23","first-page":"2776","article-title":"Progesterone stimulates degradation of urokinase plasminogen activator (u-PA) in endometrial stromal cells by increasing its inhibitor (PAI-1) and surface expression of the u-PA receptor.","volume":"80","author":"Cassl\u00e9n","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114172343700_B24","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/j.1460-2075.1990.tb08213.x","article-title":"Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.","volume":"9","author":"Cubellis","year":"1990","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019041114172343700_B25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0002-9378(94)90466-9","article-title":"Cyclic changes in endometrial tissue plasminogen activator and plasminogen activator inhibitor type 1 in women with normal menstruation and essential menorrhagia.","volume":"171","author":"Gleeson","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041114172343700_B26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0268-9499(96)80010-5","article-title":"Plasminogen activator inhibitor 2 in menstrual endometrium and in primary cultures of endometrial cells.","volume":"10","author":"Nordengren","year":"1996","journal-title":"Fibrinolysis"},{"key":"key\n\t\t\t\t2019041114172343700_B27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1160\/TH05-01-0054","article-title":"Plasminogen activation and cancer.","volume":"93","author":"Dan\u00f8","year":"2005","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2019041114172343700_B28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1160\/TH04-03-0142","article-title":"Seminal clotting and fibrinolytic balance: a possible physiological role in the male reproductive system.","volume":"92","author":"Lwaleed","year":"2004","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2019041114172343700_B29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0301-2115(00)00490-5","article-title":"The endothelium: vascular control of hemostasis.","volume":"95","author":"van Hinsbergh","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t2019041114172343700_B30","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1073\/pnas.85.15.5525","article-title":"Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.","volume":"85","author":"van Zonneveld","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114172343700_B31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev.cb.06.110190.003121","article-title":"The transforming growth factor-\u03b2 family.","volume":"6","author":"Massagu\u00e9","year":"1990","journal-title":"Annu Rev Cell Biol"},{"key":"key\n\t\t\t\t2019041114172343700_B32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(02)03154-0","article-title":"Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata.","volume":"78","author":"Sozen","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.fertnstert.2009.01.081","article-title":"Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor \u03b2-3.","volume":"93","author":"Joseph","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/endo.135.1.8013382","article-title":"Human uterine tissue throughout the menstrual cycle expresses transforming growth factor \u03b21 (TGF-\u03b21), TGF-\u03b22, TGF-\u03b2-3, and TGF-\u03b22 receptor messenger ribonucleic acid and protein contains [\u2212125I]TGF-\u03b21-binding sites.","volume":"135","author":"Chegini","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041114172343700_B35","first-page":"S31","article-title":"Modulation of transforming growth factor-\u03b23 (TGF\u03b2-3) expression in myometrium and leiomyoma","author":"Arici","year":"1994"},{"key":"key\n\t\t\t\t2019041114172343700_B36","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(00)00418-0","article-title":"Transforming growth factor-\u03b23 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation.","volume":"73","author":"Arici","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114172343700_B37","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1074\/jbc.M704883200","article-title":"Bone morphogenetic proteins signal through the transforming growth factor-\u03b2 type III receptor.","volume":"283","author":"Kirkbride","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114172343700_B38","first-page":"2840","article-title":"Expression of bone morphogenetic protein receptors type IA, -IB, and -II correlates with tumor grade in human prostate cancer tissues.","volume":"60","author":"Kim","year":"2000","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019041114172343700_B39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/rep.1.00304","article-title":"Leukemia inhibitory factor in implantation and uterine biology.","volume":"130","author":"Kimber","year":"2005","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t2019041114172343700_B40","first-page":"1129","article-title":"Sex steroids mediate HOXA 11 expression in the human peri-implantation endometrium.","volume":"84","author":"Taylor","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114172343700_B41","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukemia inhibitory factor.","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041114172343700_B42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/jrf.0.1010421","article-title":"Leukemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time.","volume":"101","author":"Charnock-Jones","year":"1994","journal-title":"J Reprod Fertil"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/96\/2\/412\/9068348\/jcem0412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T13:26:12Z","timestamp":1636809972000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/96\/2\/412\/2709505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2010-1450","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}