{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:58:48Z","timestamp":1792465128915,"version":"4.5.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Bisphenol A (BPA) is a widespread industrial compound used in the synthesis of polycarbonate plastics. In experimental animals, neonatal exposure to BPA results in a polycystic ovary-like syndrome (PCOS) in adulthood. A bidirectional interaction between androgens and BPA levels has been disclosed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine BPA levels in PCOS women as well as the association between BPA and hormonal\/metabolic parameters compared to a control group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, and Participants:<\/jats:title>\n                  <jats:p>Cross-sectional study of 71 PCOS (National Institutes of Health criteria) and 100 normal women, age- and body mass index\u2013matched, in a University hospital setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>Anthropometric, hormonal, metabolic parameters and BPA blood levels were determined. Patients (PCOS) and controls (C) were further subdivided according to body mass index into lean and overweight subgroups, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>BPA levels were significantly higher in the total PCOS group compared with the controls (1.05\u00b10.56 vs. 0.72\u00b10.37ng\/ml, P &amp;lt; 0.001). PCOS women, lean (PCOS-L) and overweight (PCOS-OW), had higher BPA levels compared to the corresponding control group lean (C-L) and overweight (C-OW): (PCOS-L = 1.13\u00b10.63 vs. C-L = 0.70\u00b10.36, P &amp;lt; 0.001) (PCOS-OW = 0.96 \u00b1 0.46 vs. C-OW = 0.72 \u00b1 0.39, P &amp;lt; 0.05). A significant association of testosterone (r = 0.192, P &amp;lt; 0.05) and androstenedione (r = 0.257, P &amp;lt; 0.05) with BPA was observed. Multiple regression analysis for BPA showed significant correlation with the existence of PCOS (r = 0.497, P &amp;lt; 0.05). BPA was also positively correlated with insulin resistance (Matsuda index) in the PCOS group (r = 0.273, P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Higher BPA levels in PCOS women compared to controls and a statistically significant positive association between androgens and BPA point to a potential role of this endocrine disruptor in PCOS pathophysiology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2010-1658","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T02:38:10Z","timestamp":1293763090000},"page":"E480-E484","source":"Crossref","is-referenced-by-count":352,"title":["Endocrine Disruptors and Polycystic Ovary Syndrome (PCOS): Elevated Serum Levels of Bisphenol A in Women with PCOS"],"prefix":"10.1210","volume":"96","author":[{"given":"Eleni","family":"Kandaraki","sequence":"first","affiliation":[{"name":"Department of Medicine (E.K.), Huddersfield Royal Infirmary Hospital, West Yorkshire HD3 3EA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Chatzigeorgiou","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology (A.C., M.K.) Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarantis","family":"Livadas","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Third Department of Internal Medicine (S.L., E.P., F.E., S.P., E.D.-K.), Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Palioura","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Third Department of Internal Medicine (S.L., E.P., F.E., S.P., E.D.-K.), Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frangiscos","family":"Economou","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Third Department of Internal Medicine (S.L., E.P., F.E., S.P., E.D.-K.), Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koutsilieris","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology (A.C., M.K.) Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Palimeri","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Third Department of Internal Medicine (S.L., E.P., F.E., S.P., E.D.-K.), Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Panidis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology (D.P.), Aristotle University of Thessaloniki, Thessaloniki 54636, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanthia","family":"Diamanti-Kandarakis","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Third Department of Internal Medicine (S.L., E.P., F.E., S.P., E.D.-K.), Medical School, National and Kapodistrian University of Athens, Athens 11854, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613301051200_B1","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1021\/jf970072i","article-title":"Determination of Bisphenol-A in reusable polycarbonate food-contact plastics and migration to food simulating liquids.","volume":"45","author":"Biles","year":"1997","journal-title":"J Agric Food Chem"},{"key":"2020071613301051200_B2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement.","volume":"4","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"key":"2020071613301051200_B3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA).","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod 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