{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:55:17Z","timestamp":1778903717374,"version":"3.51.4"},"reference-count":42,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>The association between combined oral contraceptives (OC) and the risk of myocardial infarction (MI) has been intensively studied, and conclusions are controversial. While progestogen-only contraceptives (POC) are commonly used worldwide, their impact on cardiovascular diseases is poorly investigated and remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>We carried out a meta-analysis based on EMBASE- and MEDLINE-referenced literature corresponding to OC marketed since 1960.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Eligible articles published in English language describing OC or POC use and MI outcome were reviewed, and relevant ones were extracted. All types of POC and route of administration were considered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Six case-control studies were identified. The combined odds ratio showed no increase in the MI risk with POC use (odds ratio = 1.07; 95% confidence interval, 0.62\u20131.84). This result was similar according to the route of administration, including implant, injectable, and oral POC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Data from observational studies suggest no increase in risk of MI with POC use. However, these results are based on limited data. Further investigations are needed, especially among women at high MI risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2010-2065","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T04:44:34Z","timestamp":1296708274000},"page":"1169-1174","source":"Crossref","is-referenced-by-count":58,"title":["Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis"],"prefix":"10.1210","volume":"96","author":[{"given":"Zeina","family":"Chakhtoura","sequence":"first","affiliation":[{"name":"Department of Gynecology and Endocrinology (Z.C., A.G., G.P.-B.), H\u00f4tel-Dieu Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris-Descartes University, 75004 Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Canonico","sequence":"additional","affiliation":[{"name":"Hormones and Cardiovascular Disease (M.C., P.-Y.S., G.P.-B.), Centre Epid\u00e9miologie Sant\u00e9 Population, U1018, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, 94805 Villejuif, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Gompel","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Endocrinology (Z.C., A.G., G.P.-B.), H\u00f4tel-Dieu Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris-Descartes University, 75004 Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Scarabin","sequence":"additional","affiliation":[{"name":"Hormones and Cardiovascular Disease (M.C., P.-Y.S., G.P.-B.), Centre Epid\u00e9miologie Sant\u00e9 Population, U1018, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, 94805 Villejuif, France;"},{"name":"Paris Sud 11 University (M.C., P.-Y.S.), Unit\u00e9 Mixte de Recherche inSerm 1018, 94807 Villejuif 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