{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:10:41Z","timestamp":1791101441288,"version":"4.1.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>In young women, some treatments for cancer or other conditions (such as sickle cell anemia) may give rise to primary ovarian insufficiency. Ovarian transplantation is one of the available options for fertility preservation, with highly variable pregnancy rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The objective of the study was to investigate markers of ovarian reserve and ovarian function in women up to 7 yr after orthotopic ovarian transplantation. Secondary objectives were to assess the relationship between markers of ovarian reserve and pregnancy rate along with the duration of ovarian function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>This was a prospective cohort study in 10 women, with a mean follow-up of 2.5 yr.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>The study was conducted at a university hospital in Brussels, Belgium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>Patients included 10 women who were about to receive or had previously received gonadotoxic treatment. In seven women cryopreservation of ovarian tissue was performed before starting treatment. Subsequently autografts were orthotopically transplanted in these women. Three women, who had already developed primary ovarian insufficiency due to treatment, underwent orthotopic transplantation of ovarian allograft tissue originating from their human leukocyte antigen-compatible sisters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>Serum concentrations of FSH, LH, estradiol, inhibin B, and anti-M\u00fcllerian hormone (AMH) were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>On average, first menses took place after 4.7 months. Duration of graft functioning varied from 2 to more than 60 months. FSH concentrations remained elevated, whereas estradiol levels normalized and AMH was low to undetectable. Inhibin B varied among women and was not associated with the duration of ovarian function (hazard ratio 0.966, 95% confidence interval 0.881\u20131.059). Two spontaneous pregnancies occurred. Endocrine characteristics were not significantly different in these women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Low AMH and inhibin B concentrations may suggest decreased ovarian reserve in women after ovarian transplantation. AMH and inhibin B levels may not be associated with the duration of ovarian graft function or probability to achieve a pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2010-2188","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T04:44:34Z","timestamp":1296708274000},"page":"1136-1144","source":"Crossref","is-referenced-by-count":68,"title":["Limited Value of Ovarian Function Markers following Orthotopic Transplantation of Ovarian Tissue after Gonadotoxic Treatment"],"prefix":"10.1210","volume":"96","author":[{"given":"Femi","family":"Janse","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine and Gynecology (F.J., B.C.J.M.F.), University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Donnez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain (J.D., M.-M.D.), Institut de Recherche Exp\u00e9rimentale et Clinique, Unit\u00e9 de Recherche GYNE, Department of Gynecology, Cliniques Universitaires St. Luc, B-1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Anckaert","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Radioimmunology (E.A.), Universitair Ziekenhuis Brussel, B-1090 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank H.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (F.H.d.J.), Erasmus Medical Center, 3000CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C. 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M.","family":"Fauser","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Gynecology (F.J., B.C.J.M.F.), University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Madeleine","family":"Dolmans","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain (J.D., M.-M.D.), Institut de Recherche Exp\u00e9rimentale et Clinique, Unit\u00e9 de Recherche GYNE, Department of Gynecology, Cliniques Universitaires St. Luc, B-1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613470297000_B1","unstructured":"Altekruse\n              SF\n             , KosaryCL , KrapchoM , NeymanN , AminouR , WaldronW , RuhlJ , HowladerN , TatalovichZ , ChoH , MariottoA , EisnerMP , LewisDR , CroninK , ChenHS , FeuerEJ , StinchcombDG , EdwardsBK\n          2010\n          SEER cancer statistics review, 1975\u20132007. 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