{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:04:07Z","timestamp":1790057047965,"version":"4.0.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Our objective was to investigate psychological correlates in a population with primary aldosteronism (PA) using methods found to be sensitive and reliable in psychosomatic research.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Twenty-three PA patients (12 male, 11 female; mean age 50 \u00b1 9 yr) were compared with 23 patients with essential hypertension (EH) (15 male, eight female; mean age 47 \u00b1 8 yr) and 23 matched normotensive subjects. A modified version of the Structural Clinical Interview for DSM-IV, a shortened version of the structured interview for the Diagnostic Criteria for Psychosomatic Research, and two self-rating questionnaires, the Psychosocial Index and the Symptom Questionnaire, were administered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Twelve of 23 patients with PA (52.2%) suffered from an anxiety disorder compared with four of 23 with EH (17.4%) and one control (4.3%) (P &amp;lt; 0.001). Generalized anxiety disorder was more frequent in PA than in EH patients and controls (P &amp;lt; 0.05). As assessed by Diagnostic Criteria for Psychosomatic Research, irritable mood was more frequent in PA and EH compared with controls (P &amp;lt; 0.05) but did not differentiate PA from EH. According to Psychosocial Index results, patients with PA had higher levels of stress (P &amp;lt; 0.01) and psychological distress (P &amp;lt; 0.01) and lower level of well-being (P &amp;lt; 0.05) than controls. Compared with EH patients, PA patients had higher scores in stress subscale (P &amp;lt; 0.05). The Symptom Questionnaire showed higher levels of anxiety (P &amp;lt; 0.01), depression (P &amp;lt; 0.01) and somatization (P &amp;lt; 0.01) and lower physical well-being (P &amp;lt; 0.05) in PA than controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>A role of mineralocorticoid regulatory mechanisms in clinical situations concerned with anxiety and stress is suggested.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2010-2723","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T03:51:55Z","timestamp":1299729115000},"page":"E878-E883","source":"Crossref","is-referenced-by-count":93,"title":["Psychological Assessment of Primary Aldosteronism: A Controlled Study"],"prefix":"10.1210","volume":"96","author":[{"given":"Nicoletta","family":"Sonino","sequence":"first","affiliation":[{"name":"Department of Statistical Sciences (N.S.) 35128 Padova, Italy;"},{"name":"University of Padova, and Department of Mental Health (N.S.), 35128 Padova, Italy;"},{"name":"Department of Psychiatry (N.S., G.A.F.), State University of New York at Buffalo, Buffalo, New York 14260;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tomba","sequence":"additional","affiliation":[{"name":"Laboratory of Psychosomatics and Clinimetrics (E.T., G.A.F.), Department of Psychology, University of Bologna, 40127 Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Genesia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (M.L.G., C.B., P.M., F.V.), University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bertello","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (M.L.G., C.B., P.M., F.V.), University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mulatero","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (M.L.G., C.B., P.M., F.V.), University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Veglio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (M.L.G., C.B., P.M., F.V.), University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A.","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (N.S., G.A.F.), State University of New York at Buffalo, Buffalo, New York 14260;"},{"name":"Laboratory of Psychosomatics and Clinimetrics (E.T., G.A.F.), Department of Psychology, University of Bologna, 40127 Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fallo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (F.F.), 35128 Padova, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616344733300_B1","first-page":"358","article-title":"Hyperaldosteronism (Conn's disease) presenting as depression.","volume":"40","author":"Malinow","year":"1979","journal-title":"J Clin Psychiatry"},{"key":"2020071616344733300_B2","first-page":"537","article-title":"Primary aldosteronism and depression.","volume":"87","author":"Avery","year":"1984","journal-title":"NZ Med J"},{"key":"2020071616344733300_B3","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1176\/appi.ajp.162.6.1226","article-title":"Conn's syndrome presenting as depression.","volume":"162","author":"Kharshid","year":"2005","journal-title":"Am J Psychiatry"},{"key":"2020071616344733300_B4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000093956","article-title":"Psychological aspects of primary aldosteronism.","volume":"75","author":"Sonino","year":"2006","journal-title":"Psychother Psychosom"},{"key":"2020071616344733300_B5","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1210\/jc.2009-1763","article-title":"Improved quality of life, blood pressure, and biochemical status following laparoscopic adrenalectomy for unilateral primary aldosteronism.","volume":"95","author":"Sukor","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616344733300_B6","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4088\/JCP.v66n0707","article-title":"The clinical domains of psychosomatic medicine.","volume":"66","author":"Fava","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"2020071616344733300_B7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2265.2007.02951.x","article-title":"Psychological impairment in patients treated for pituitary disease: a controlled study.","volume":"67","author":"Sonino","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071616344733300_B8","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","article-title":"Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).","volume":"25","author":"Mancia","year":"2007","journal-title":"J Hypertens"},{"key":"2020071616344733300_B9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1210\/jc.2005-1733","article-title":"Prevalence and characteristics of the metabolic syndrome in primary 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