{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:06:20Z","timestamp":1792659980186,"version":"4.5.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Besides short stature and gonadal dysgenesis, Turner syndrome (TS) is associated with various abnormalities. Adults with TS have a reduced life expectancy, mainly related to structural abnormalities of the heart and aorta, and an increased risk of atherosclerosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Our objective was to investigate the yield of an initial standardized multidisciplinary screening in adult TS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting:<\/jats:title>\n                  <jats:p>This was an observational study at a multidisciplinary care unit for adult women with TS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>Participants were adult women with TS (n = 150). Mean age was 31.0 \u00b1 10.4 yr, with 47% karyotype 45,X.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions:<\/jats:title>\n                  <jats:p>All women were consulted by an endocrinologist, a gynecologist, a cardiologist, an otorhinolaryngologist, and when indicated, a psychologist. The screening included magnetic resonance imaging of the heart and aorta, echocardiography, electrocardiogram, dual-energy x-ray absorptiometry, renal ultrasound, audiogram, and laboratory investigations according to international expert recommendations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures:<\/jats:title>\n                  <jats:p>New diagnoses and prevalence of TS-associated morbidity were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Thirty percent of patients currently lacked medical follow-up, and 15% lacked estrogen replacement therapy in the recent last years. The following disorders were newly diagnosed: bicuspid aortic valve (n = 13), coarctation of the aorta (n = 9), elongation of the transverse aortic arch (n = 27), dilation of the aorta (n = 34), osteoporosis (n = 8), osteopenia (n = 56), renal abnormalities (n = 7), subclinical hypothyroidism (n = 33), celiac disease (n = 3), glucose intolerance (n = 12), dyslipidemia (n = 52), hypertension (n = 39), and hearing loss warranting a hearing aid (n = 8). Psychological consultation was needed in 23 cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Standardized multidisciplinary evaluation of adult women with TS as advocated by expert opinion is effective and identifies significant morbidity. Girls with TS benefit from a careful transition to ongoing adult medical care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2011-0346","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T01:50:51Z","timestamp":1310608251000},"page":"E1517-E1526","source":"Crossref","is-referenced-by-count":104,"title":["Standardized Multidisciplinary Evaluation Yields Significant Previously Undiagnosed Morbidity in Adult Women with Turner Syndrome"],"prefix":"10.1210","volume":"96","author":[{"given":"Kim","family":"Freriks","sequence":"first","affiliation":[{"name":"Departments of Endocrinology (K.F., R.T.N.-M., A.R.M.M.H., H.J.L.M.T.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Cardiology (J.T.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina C. M.","family":"Beerendonk","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology (C.C.M.B., D.D.M.B.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Verhaak","sequence":"additional","affiliation":[{"name":"Psychology (C.M.V.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana T.","family":"Netea-Maier","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (K.F., R.T.N.-M., A.R.M.M.H., H.J.L.M.T.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barto J.","family":"Otten","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology (B.J.O.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didi D. M.","family":"Braat","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology (C.C.M.B., D.D.M.B.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique F. C. M.","family":"Smeets","sequence":"additional","affiliation":[{"name":"Human Genetics (D.F.C.M.S.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H. P. M.","family":"Kunst","sequence":"additional","affiliation":[{"name":"Otolaryngology (D.H.P.M.K.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad R. M. M.","family":"Hermus","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (K.F., R.T.N.-M., A.R.M.M.H., H.J.L.M.T.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri J. L. M.","family":"Timmers","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (K.F., R.T.N.-M., A.R.M.M.H., H.J.L.M.T.), Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071617385768700_B1","first-page":"209","article-title":"Sex chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark.","volume":"26","author":"Nielsen","year":"1990","journal-title":"Birth Defects Orig Artic Ser"},{"key":"2020071617385768700_B2","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1210\/jc.2008-1049","article-title":"Mortality in women with turner syndrome in Great Britain: a national cohort study.","volume":"93","author":"Schoemaker","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071617385768700_B3","first-page":"120","article-title":"Turner's syndrome in 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Cardiology.","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"2020071617385768700_B16","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1210\/jc.2004-1090","article-title":"A comparison of echocardiography and magnetic resonance imaging in cardiovascular screening of adults with Turner syndrome.","volume":"89","author":"Ostberg","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071617385768700_B17","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1161\/CIRCULATIONAHA.106.685487","article-title":"Aortic dilatation and dissection in Turner syndrome.","volume":"116","author":"Matura","year":"2007","journal-title":"Circulation"},{"key":"2020071617385768700_B18","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1017\/S1047951109990874","article-title":"Aortic distensibility and dilation in Turner's syndrome.","volume":"19","author":"Sharma","year":"2009","journal-title":"Cardiol 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