{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:59:24Z","timestamp":1767707964225},"reference-count":15,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Graves' disease (GD) is a common autoimmune disease that affects the thyroid gland. Its pathogenesis is tightly involved with aberrant proinflammatory cytokine production. Osteopontin (OPN), an extracellular matrix protein of pleiotropic properties, has recently been recognized as a potent inflammatory cytokine in several autoimmune diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This study sought to explore the pathophysiological role of OPN in GD by comparing OPN levels in initial GD patients and healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Seventy-six patients who met criteria for initial GD and sixty-five healthy controls were recruited. OPN and other clinical GD diagnosis parameters were measured. In addition, the coexpression of several OPN receptors as well as various nuclear factor-\u03baB (NF-\u03baB) downstream target genes were examined in peripheral blood mononuclear cells from human subjects. The effect of OPN on NF-\u03baB activation was determined by in vitro assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>We demonstrated for the first time that the OPN levels are enhanced in serum from GD patients. OPN levels are strongly associated with clinical serum parameters for GD diagnosis. The coexpression of selective OPN receptors and inflammatory response genes was enhanced in peripheral blood mononuclear cells from GD patients. Furthermore, serum from GD patients activated NF-\u03baB activity in vitro, which was significantly suppressed by OPN monoclonal antibody abrogation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>These data indicated a clinical correlation between serum OPN levels and GD. OPN could affect GD development through NF-\u03baB activation and the subsequent changes in inflammatory milieu. OPN could serve as a novel biomarker for GD as well as a potential target for GD treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2011-1339","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:26:43Z","timestamp":1315441603000},"page":"E1866-E1870","source":"Crossref","is-referenced-by-count":19,"title":["The Expression and Pathophysiological Role of Osteopontin in Graves' Disease"],"prefix":"10.1210","volume":"96","author":[{"given":"Lingyan","family":"Xu","sequence":"first","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism (L.X., X.M., B.C., S.W.), Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine"},{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism (L.X., X.M., B.C., S.W.), Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine"},{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes 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Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Qi","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"},{"name":"Department of Endocrinology and Metabolism, and Division of Endocrinology and Metabolism (Y.W., Xiaoli Li, Y.Q., Xiaoying Li, G.N.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cui","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism (L.X., X.M., B.C., S.W.), Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine"},{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"},{"name":"Department of Endocrinology and Metabolism, and Division of Endocrinology and Metabolism (Y.W., Xiaoli Li, Y.Q., Xiaoying Li, G.N.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases (L.X., X.M., Y.W., Xiaoli Li, Y.Q., B.C., Xiaoying Li, G.N., S.W.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China"},{"name":"Department of Endocrinology and Metabolism, and Division of Endocrinology and Metabolism (Y.W., Xiaoli Li, Y.Q., Xiaoying Li, G.N.), E-Institutes of Shanghai Universities, Rui-Jin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, 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