{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:10:56Z","timestamp":1791306656263,"version":"4.3.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"DOI":"10.1210\/jc.2011-1995","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T01:24:46Z","timestamp":1326331486000},"page":"416-425","source":"Crossref","is-referenced-by-count":237,"title":["Long-Term Mortality after Recombinant Growth Hormone Treatment for Isolated Growth Hormone Deficiency or Childhood Short Stature: Preliminary Report of the French SAGhE Study"],"prefix":"10.1210","volume":"97","author":[{"given":"Jean-Claude","family":"Carel","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology (J.-C.C., F.L., D.M.-H.), 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Ecosse","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit and Approches Psychologiques et Epid\u00e9miologiques des Maladies Chroniques Equipe d'Accueil 4360 (E.E., J.C.), Groupe Hospitalier Cochin-Saint Vincent de Paul and University Paris Descartes, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Landier","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology (J.-C.C., F.L., D.M.-H.), 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Meguellati-Hakkas","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetology (J.-C.C., F.L., D.M.-H.), 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentia","family":"Kaguelidou","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale CIE5 and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance, Department of Paediatric Pharmacology and Pharmacogenetics (F.K.), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale CIC9202, Assistance Publique-H\u00f4pitaux de Paris Robert Debr\u00e9 Hospital and University Paris 7 Denis Diderot, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Rey","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (G.R.), Centre of Epidemiology on Medical Causes of Death, 78110 Le V\u00e9sinet, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Coste","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit and Approches Psychologiques et Epid\u00e9miologiques des Maladies Chroniques Equipe d'Accueil 4360 (E.E., J.C.), Groupe Hospitalier Cochin-Saint Vincent de Paul and University Paris Descartes, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041117020286300_B1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpeds.2010.10.004","article-title":"Pediatric endo-cosmetology and the evolution of growth diagnosis and treatment.","volume":"158","author":"Rosenbloom","year":"2011","journal-title":"J Pediatr"},{"key":"2019041117020286300_B2","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1210\/jcem.84.12.6189","article-title":"Commentary. Four decades of growth hormone therapy for short children: what have we achieved?","volume":"84","author":"Guyda","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1210\/jc.2009-2364","article-title":"Growth hormone post-marketing surveillance: safety, sales, and the unfinished task ahead.","volume":"95","author":"Allen","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B4","first-page":"1868","article-title":"Consensus","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/jc.2009-0178","article-title":"Long-term safety of recombinant human growth hormone in children.","volume":"95","author":"Bell","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jpeds.2010.02.028","article-title":"Growth hormone treatment in children is not associated with an increase in the incidence of cancer: experience from KIGS (Pfizer International Growth Database).","volume":"157","author":"Wilton","year":"2010","journal-title":"J Pediatr"},{"key":"2019041117020286300_B7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(02)09519-3","article-title":"Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959\u201385: a cohort study.","volume":"360","author":"Swerdlow","year":"2002","journal-title":"Lancet"},{"key":"2019041117020286300_B8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jpeds.2003.12.036","article-title":"Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients.","volume":"144","author":"Mills","year":"2004","journal-title":"J Pediatr"},{"key":"2019041117020286300_B9","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1210\/jc.2006-0656","article-title":"Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor.","volume":"91","author":"Ergun-Longmire","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B10","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1172\/JCI39375","article-title":"Acromegaly pathogenesis and treatment.","volume":"119","author":"Melmed","year":"2009","journal-title":"J Clin Invest"},{"key":"2019041117020286300_B11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1210\/er.2009-0033","article-title":"Mortality in patients with pituitary disease.","volume":"31","author":"Sherlock","year":"2010","journal-title":"Endocr Rev"},{"key":"2019041117020286300_B12","doi-asserted-by":"crossref","first-page":"70ra13","DOI":"10.1126\/scitranslmed.3001845","article-title":"Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.","volume":"3","author":"Guevara-Aguirre","year":"2011","journal-title":"Sci Transl Med"},{"key":"2019041117020286300_B13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc1387","article-title":"Insulin-like growth factors and neoplasia.","volume":"4","author":"Pollak","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"2019041117020286300_B14","unstructured":"Safety and Appropriateness of Growth Hormone Treatments in Europe (SAGhE) study. http:\/\/saghe.aphp.fr\/site\/spip.php\/"},{"key":"2019041117020286300_B15","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/bmj.315.7110.708","article-title":"Long term results of GH treatment in short stature children: a population register-based study.","volume":"315","author":"Coste","year":"1997","journal-title":"BMJ"},{"key":"2019041117020286300_B16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/bmj.325.7355.70","article-title":"Adult height after long-term recombinant growth hormone treatment for idiopathic isolated growth hormone deficiency: observational follow-up study of the French population-based registry.","volume":"325","author":"Carel","year":"2002","journal-title":"BMJ"},{"key":"2019041117020286300_B17","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/ije\/24.3.522","article-title":"United States mortality from ill-defined causes, 1968\u20131988: potential effects on heart disease mortality trends.","volume":"24","author":"Armstrong","year":"1995","journal-title":"Int J Epidemiol"},{"key":"2019041117020286300_B18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1007570405888","article-title":"Ill-defined and multiple causes on death certificates\u2014a study of misclassification in mortality statistics.","volume":"15","author":"D'Amico","year":"1999","journal-title":"Eur J Epidemiol"},{"key":"2019041117020286300_B19","first-page":"447","article-title":"Improvement of the quality and comparability of causes-of-death statistics inside the European Community. EUROSTAT Task Force on \u201ccauses of death statistics.\u201d","volume":"46","author":"Jougla","year":"1998","journal-title":"Revue Epidemiol Sante Publique"},{"key":"2019041117020286300_B20","first-page":"1","article-title":"Statistical methods in cancer research. Volume II\u2014the design and analysis of cohort studies","author":"Breslow","year":"1987","journal-title":"IARC Sci Publ"},{"key":"2019041117020286300_B21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet"},{"key":"2019041117020286300_B22","doi-asserted-by":"crossref","DOI":"10.1002\/9780470316696","article-title":"Multiple imputation for nonresponse in surveys","author":"Rubin","year":"1987"},{"key":"2019041117020286300_B23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/edrv.19.2.0329","article-title":"The diagnosis of growth hormone deficiency in children and adults.","volume":"19","author":"Shalet","year":"1998","journal-title":"Endocr Rev"},{"key":"2019041117020286300_B24","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/oxfordjournals.aje.a010155","article-title":"Relation of adult height to cause-specific and total mortality: a prospective follow-up study of 31,199 middle-aged men and women in Finland.","volume":"151","author":"Jousilahti","year":"2000","journal-title":"Am J Epidemiol"},{"key":"2019041117020286300_B25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/aje\/kwg173","article-title":"Adult height and cause-specific mortality: a large prospective study of South Korean men.","volume":"158","author":"Song","year":"2003","journal-title":"Am J Epidemiol"},{"key":"2019041117020286300_B26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/aje\/kwn187","article-title":"Adult height and the risk of mortality in South Korean women.","volume":"168","author":"Song","year":"2008","journal-title":"Am J Epidemiol"},{"key":"2019041117020286300_B27","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/oxfordjournals.aje.a009567","article-title":"Bias in the standardized mortality ratio when using general population rates to estimate expected number of deaths.","volume":"148","author":"Jones","year":"1998","journal-title":"Am J Epidemiol"},{"key":"2019041117020286300_B28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1470-2045(11)70154-1","article-title":"Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk.","volume":"12","author":"Green","year":"2011","journal-title":"Lancet Oncol"},{"key":"2019041117020286300_B29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1210\/jcem.82.2.3726","article-title":"Growth hormone (GH) retesting and auxological data in 131 GH-deficient patients after completion of treatment.","volume":"82","author":"Tauber","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease.","volume":"2","author":"Barker","year":"1989","journal-title":"Lancet"},{"key":"2019041117020286300_B31","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults.","volume":"353","author":"Barker","year":"2005","journal-title":"N Engl J Med"},{"key":"2019041117020286300_B32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.respe.2008.03.117","article-title":"Cancer incidence and mortality in France over the period 1980\u20132005.","volume":"56","author":"Belot","year":"2008","journal-title":"Rev Epidemiol Sante Publique"},{"key":"2019041117020286300_B33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/01.mph.0000169251.57611.8e","article-title":"Height as a risk factor for osteosarcoma.","volume":"27","author":"Longhi","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"2019041117020286300_B34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1158\/1535-7163.MCT-09-0555","article-title":"A fully human insulin-like growth factor-I receptor antibody SCH 717454 (robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts.","volume":"9","author":"Wang","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"2019041117020286300_B35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd2359","article-title":"Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer.","volume":"6","author":"Clemmons","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"2019041117020286300_B36","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1210\/jcem.87.7.8606","article-title":"Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study.","volume":"87","author":"Sklar","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117020286300_B37","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tem.2005.07.004","article-title":"Cerebrovascular disease in patients with pituitary tumors.","volume":"16","author":"Erfurth","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"2019041117020286300_B38","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/jech.55.6.404","article-title":"The relation between adult height and haemorrhagic and ischaemic stroke in the Renfrew\/Paisley study.","volume":"55","author":"McCarron","year":"2001","journal-title":"J Epidemiol Community Health"},{"key":"2019041117020286300_B39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ije\/dyn231","article-title":"Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men.","volume":"38","author":"Silventoinen","year":"2009","journal-title":"Int J Epidemiol"},{"key":"2019041117020286300_B40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.STR.0000251806.01676.60","article-title":"Relation of adult height with stroke mortality in Japan: NIPPON DATA80.","volume":"38","author":"Hozawa","year":"2007","journal-title":"Stroke"},{"key":"2019041117020286300_B41","unstructured":"Nutropin product information. http:\/\/www.gene.com\/gene\/products\/information\/opportunistic\/nutropin\/insert.jsp"},{"key":"2019041117020286300_B42","unstructured":"Genotropin product information\n          \n            http:\/\/www.pfizer.com\/products\/rx\/rx_product_genotropin.jsp"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/2\/416\/10412655\/jcem0416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:50:57Z","timestamp":1555033857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/97\/2\/416\/2836316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2011-1995","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,1]]}}}