{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:32Z","timestamp":1787021252318,"version":"build-2736575974"},"reference-count":16,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Anomalous venous drainage can lead to false-negative inferior petrosal sinus sampling (IPSS) results. Baseline inferior petrosal sinus to peripheral (IPS\/P) prolactin ratio higher than 1.8 ipsilateral to the highest ACTH ratio has been proposed to verify successful catheterization. Prolactin-normalized ACTH IPS\/P ratios may differentiate Cushing's disease (CD) from ectopic ACTH syndrome (EAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our objective was to examine the utility of prolactin measurement during IPSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of prolactin levels in basal and CRH-stimulated IPSS samples in ACTH-dependent Cushing's syndrome (2007\u20132010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-five of 29 patients had a pathologically proven diagnosis (17 CD and eight EAS). IPSS results were partitioned into true positive for CD (n = 16), true negative (n = 7), false negative (n = 1), and false positive (n = 1). Prolactin IPS\/P ratio suggested successful IPSS in eight of 11 with abnormal venograms. Baseline prolactin IPS\/P ratio was helpful in two patients with abnormal venograms and false-negative (catheterization unsuccessful) or true-negative (catheterization successful) IPSS results; the normalized ratio correctly diagnosed their disease. Normalized ACTH IPS\/P ratio was at least 1.3 in all with CD, but prolactin IPS\/P ratios were misleadingly low in two. One patient with cyclic EAS had a false-positive IPSS when eucortisolemic (baseline prolactin IPS\/P = 1.7; normalized ratio = 5.6). All other EAS patients had normalized ratios no higher than 0.7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prolactin measurement and evaluation of the venogram can improve diagnostic accuracy when IPSS results suggest EAS but is not necessary with positive IPSS results. Confirmation of hypercortisolemia remains a prerequisite for IPSS. A normalized ratio of 0.7\u20131.3 was not diagnostic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2011-2149","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T20:29:37Z","timestamp":1319660977000},"page":"3687-3694","source":"Crossref","is-referenced-by-count":72,"title":["Prolactin as a Marker of Successful Catheterization during IPSS in Patients with ACTH-Dependent Cushing's Syndrome"],"prefix":"10.1210","volume":"96","author":[{"given":"S. T.","family":"Sharma","sequence":"first","affiliation":[{"name":"Program on Reproductive and Adult Endocrinology (S.T.S., L.K.N.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Raff","sequence":"additional","affiliation":[{"name":"Endocrine Research Laboratory (H.R.), Aurora St. Luke's Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53207"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Nieman","sequence":"additional","affiliation":[{"name":"Program on Reproductive and Adult Endocrinology (S.T.S., L.K.N.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071619410973100_B1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing's syndrome.","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"2020071619410973100_B2","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1210\/jc.2003-032249","article-title":"Diagnostic errors after inferior petrosal sinus sampling.","volume":"89","author":"Swearingen","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619410973100_B3","first-page":"533","article-title":"The hypoplastic inferior petrosal sinus: a potential 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