{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:50:35Z","timestamp":1789537835805,"version":"build-2803163510"},"reference-count":21,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>We aimed to test for differences in PTH levels and parameters of calcium and vitamin D metabolism in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH) and to evaluate the impact of PA treatment on these laboratory values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, and Participants:<\/jats:title>\n                  <jats:p>The Graz Endocrine Causes of Hypertension study includes hypertensive patients referred for screening for endocrine hypertension at a tertiary care center in Graz, Austria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>Differences in PTH levels between patients with PA and EH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Among 192 patients, we identified 10 patients with PA and 182 with EH. PTH levels (mean \u00b1 sd in picograms per milliliter) were significantly higher in PA patients compared with EH (67.8 \u00b1 26.9 vs. 46.5 \u00b1 20.9; P = 0.002). After treatment of PA with either adrenal surgery (n = 5) or mineralocorticoid receptor antagonists (n = 5), PTH concentrations decreased to 43.9 \u00b1 14.9 (P = 0.023). Serum 25-hydroxyvitamin D concentrations were similar in both groups. Compared with EH, serum calcium concentrations were significantly lower (2.35 \u00b1 0.10 vs. 2.26 \u00b1 0.10 mmol\/liter; P = 0.013), and there was a nonsignificant trend toward an increased spot urine calcium to creatinine ratio in PA [median (interquartile range) 0.19 (0.11\u20130.31) vs. 0.33 (0.12\u20130.53); P = 0.094].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Our results suggest that PA contributes to secondary hyperparathyroidism. Further studies are warranted to evaluate whether PTH has implications for PA diagnostics and whether mineralocorticoid receptor antagonists have a general impact on PTH and calcium metabolism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2011-2183","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T01:53:13Z","timestamp":1319075593000},"page":"E75-E79","source":"Crossref","is-referenced-by-count":98,"title":["Hyperparathyroidism in Patients with Primary Aldosteronism: Cross-Sectional and Interventional Data from the GECOH Study"],"prefix":"10.1210","volume":"97","author":[{"given":"Stefan","family":"Pilz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"},{"name":"Department of Epidemiology and Biostatistics and EMGO Institute for Health and Care Research (S.P.), VU University Medical Center, 1081 BT Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kienreich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Department of Medicine (C.D.), Division of Nephrology, University of W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Medicine (E.R.), Division of Nephrology, University Hospital Heidelberg, 69115 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Fahrleitner-Pammer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gaksch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meinitzer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, and Clinical Institute of Medical and Chemical Laboratory Diagnostics (A.M., W.M.), Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, and Clinical Institute of Medical and Chemical Laboratory Diagnostics (A.M., W.M.), Medical University of Graz, 8036 Graz, Austria"},{"name":"Synlab-Academy (W.M.), Synlab Services LLC, 69214 Eppelheim, Germany"},{"name":"Mannheim Institute of Public Health (W.M.), Medical Faculty Mannheim, Ruperto Carola University Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Pieber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Tomaschitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071615462199600_B1","first-page":"1243","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.","volume-title":"J Am Coll 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