{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:24:06Z","timestamp":1791429846905,"version":"4.3.3"},"reference-count":28,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"DOI":"10.1210\/jc.2011-2384","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T06:24:46Z","timestamp":1326349486000},"page":"881-889","source":"Crossref","is-referenced-by-count":128,"title":["18-Hydroxycorticosterone, 18-Hydroxycortisol, and 18-Oxocortisol in the Diagnosis of Primary Aldosteronism and Its Subtypes"],"prefix":"10.1210","volume":"97","author":[{"given":"Paolo","family":"Mulatero","sequence":"first","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania Morra","family":"di Cella","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Monticone","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Manzo","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory (M.M., G.M.), San Giovanni Battista University Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Mengozzi","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory (M.M., G.M.), San Giovanni Battista University Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Rabbia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Terzolo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences (M.T.), Division of Internal Medicine 1, University of Torino, San Luigi Hospital, 10043 Orbassano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise P.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (E.P.G.-S., C.E.G.-S.), G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, Mississippi 39216"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (E.P.G.-S., C.E.G.-S.), G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, Mississippi 39216"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Veglio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Experimental Oncology (P.M., S.M.d.C., S.M., D.S., F.R., F.V.), Division of Internal Medicine and Hypertension Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113500277400_B1","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society Clinical Practice Guideline.","volume":"93","author":"Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11154-011-9156-6","article-title":"Diagnosis and treatment of primary aldosteronism.","volume":"12","author":"Mulatero","year":"2011","journal-title":"Rev Endocr Metab Disord"},{"key":"key\n\t\t\t\t2019041113500277400_B3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.","volume":"45","author":"Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041113500277400_B4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1210\/jc.2008-2116","article-title":"Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German Conn's Registry.","volume":"94","author":"Born-Frontsberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/s-0029-1246186","article-title":"Confirmatory tests in the diagnosis of primary aldosteronism.","volume":"42","author":"Mulatero","year":"2010","journal-title":"Horm Metab Res"},{"key":"key\n\t\t\t\t2019041113500277400_B6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11906-009-0038-1","article-title":"Differential diagnosis of primary aldosteronism subtypes.","volume":"11","author":"Mulatero","year":"2009","journal-title":"Curr Hypertens Rep"},{"key":"key\n\t\t\t\t2019041113500277400_B7","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1073\/pnas.89.4.1458","article-title":"Role of steroid 11 \u03b2-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.","volume":"89","author":"Kawamoto","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113500277400_B8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nsb0197-32","article-title":"The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme.","volume":"4","author":"Curnow","year":"1997","journal-title":"Nat Struct Biol"},{"key":"key\n\t\t\t\t2019041113500277400_B9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1210\/endo-92-5-1389","article-title":"The binding of 18-hydroxydeoxycorticosterone and 18-hydroxycorticosterone to mineralocorticoid and glucocorticoid receptors in the rat kidney.","volume":"92","author":"Feldman","year":"1973","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113500277400_B10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.7326\/0003-4819-121-11-199412010-00010","article-title":"Diagnosis and treatment of primary hyperaldosteronism.","volume":"121","author":"Blumenfeld","year":"1994","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113500277400_B11","first-page":"873","article-title":"The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism.","volume":"76","author":"Ulick","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B12","first-page":"3996","article-title":"Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol.","volume":"83","author":"Mulatero","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B13","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1210\/jc.2004-0379","article-title":"Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.","volume":"89","author":"Freel","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng0992-66","article-title":"Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.","volume":"2","author":"Lifton","year":"1992","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019041113500277400_B15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/01.HYP.38.3.688","article-title":"Serum 18-hydroxycortisol in primary aldosteronism, hypertension, and normotensives.","volume":"38","author":"Mosso","year":"2001","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113500277400_B16","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/jc.2007-2055","article-title":"Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypes.","volume":"93","author":"Mulatero","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B17","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1210\/jc.2006-0078","article-title":"Comparison of confirmatory tests for the diagnosis of primary aldosteronism.","volume":"91","author":"Mulatero","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/HYPERTENSIONAHA.109.146613","article-title":"Impact of different diagnostic criteria during adrenal vein sampling on reproducibility of subtype diagnosis in patients with primary aldosteronism.","volume":"55","author":"Mulatero","year":"2010","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113500277400_B19","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1210\/jcem.87.7.8647","article-title":"Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation Italian pedigree.","volume":"87","author":"Mulatero","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.beem.2009.04.001","article-title":"Management of adrenal incidentaloma.","volume":"23","author":"Terzolo","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0960-0760(92)90239-F","article-title":"Biotin-hydrazide derivatives for the development of steroid enzyme-linked immunoassays.","volume":"43","author":"G\u00f3mez-S\u00e1nchez","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041113500277400_B22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0960-0760(02)00142-5","article-title":"A time-resolved fluoroimmunoassay for 18-oxocortisol and 18-hydroxycortisol. Development of a monoclonal antibody to 18-oxocortisol.","volume":"82","author":"Morra di Cella","year":"2002","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041113500277400_B23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0378-4347(00)81936-2","article-title":"Simplified method for the determination of plasma 18-hydroxycorticosterone.","volume":"426","author":"Holland","year":"1988","journal-title":"J Chromatogr"},{"key":"key\n\t\t\t\t2019041113500277400_B24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/jc.2003-031337","article-title":"Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents.","volume":"89","author":"Mulatero","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tem.2005.02.006","article-title":"Plasma renin and aldosterone measurements in low renin hypertensive states.","volume":"16","author":"Sealey","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B26","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1210\/jc.2003-032179","article-title":"Aldosterone to renin ratio in a primary care setting: the Bussolengo study.","volume":"89","author":"Olivieri","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B27","doi-asserted-by":"crossref","first-page":"E1272","DOI":"10.1210\/jc.2010-2785","article-title":"18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism.","volume":"96","author":"Nakamura","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113500277400_B28","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1210\/jcem.85.12.7086","article-title":"Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma.","volume":"85","author":"Phillips","year":"2000","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/3\/881\/10416051\/jcem0881.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T11:00:37Z","timestamp":1561201237000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/97\/3\/881\/2536359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2011-2384","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,1]]}}}