{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:51:02Z","timestamp":1778899862894,"version":"3.51.4"},"reference-count":29,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Agenesis of the internal carotid artery and hypoplasia of the internal carotid artery are rare congenital abnormalities, involving less than 0.01% of the general population. Congenital hypopituitarism is also a rare condition; thus, the association of the two entities is unlikely to be casual. We describe one pediatric case of agenesis of the internal carotid artery with hypopituitarism and review other known cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Acquisition and Synthesis:<\/jats:title>\n                    <jats:p>In this brief clinical case seminar, we summarize the current understanding of this association based on a MEDLINE search of all peer-reviewed publications (original articles and reviews) on this topic between 1980 and 2011. We found nine other cases, mainly diagnosed during childhood. Defects of pituitary function varied among cases; in four, midline anomalies were present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There are two theories that are not mutually exclusive to explain the association of congenital vascular malformation and pituitary hypoplasia with hypopituitarism: the first involves hemodynamic mechanisms, and the second, complex neural-crest differentiation and\/or migration disorders. Whatever the real physiopathological mechanism responsible for this condition, it could be considered as a new clinical entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2011-3389","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T15:38:15Z","timestamp":1349537895000},"page":"3414-3420","source":"Crossref","is-referenced-by-count":9,"title":["Agenesis of Internal Carotid Artery and Hypopituitarism: Case Report and Review of Literature"],"prefix":"10.1210","volume":"97","author":[{"given":"S.","family":"Savasta","sequence":"first","affiliation":[{"name":"Clinica Pediatrica (S.S., P.M., F.I., L.S., G.L., D.L.), Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Merli","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica (S.S., P.M., F.I., L.S., G.L., D.L.), Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Introzzi","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica (S.S., P.M., F.I., L.S., G.L., D.L.), Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Strocchio","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica (S.S., P.M., F.I., L.S., G.L., D.L.), Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lanati","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica (S.S., P.M., F.I., L.S., G.L., D.L.), Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Incorpora","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Pediatria Azienda Rilievo Nazionale Alta Specializzazione \u201cGaribaldi\u201d Catania (G.I.), 95126 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Della Mina","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Molecolare (E.D.M., O.Z.), Universit\u00e0 di Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Simoncelli","sequence":"additional","affiliation":[{"name":"Radiodiagnostica (A.S.), Fondazione IRCCS Policlinico San Matteo Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Zuffardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Molecolare (E.D.M., O.Z.), 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