{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:01Z","timestamp":1791288961969,"version":"4.3.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Pheochromocytoma and paraganglioma are rare neural-crest-derived tumors. They are metastatic in 15% of cases, and the identification of a germline mutation in the SDHB gene is a predictive risk factor for malignancy and poor prognosis. To date, the link between SDHB mutations and malignancy is still missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Epithelial to mesenchymal transition (EMT) is a developmental event, reactivated in cancer cells to promote cell mobility and invasiveness. The aim of this study was to address the participation of EMT in the metastatic evolution of pheochromocytoma\/paraganglioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Patients:<\/jats:title>\n                    <jats:p>Transcriptomic profiling of EMT was performed on 188 tumor samples, using a set of 94 genes implicated in this pathway. Activation of EMT was further confirmed at protein level by immunohistochemistry in a second set of 93 tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Hierarchical unsupervised classification showed that most SDHB-metastatic samples clustered together, indicating that EMT is differently regulated in these tumors. Major actors of EMT, metalloproteases and components of cellular junctions, were either up-regulated (LOXL2, TWIST, TCF3, MMP2, and MMP1) or down-regulated (KRT19 and CDH2) in SDHB-metastatic tumors compared with nonmetastatic ones. Interestingly, within metastatic tumors, most of these genes (LOXL2, TWIST, TCF3, MMP2, and KRT19) also allowed us to discriminate SDHB-mutated from non-SDHB-related tumors. In the second set of tumors, we studied Snail1\/2 expression by immunohistochemistry and observed its specific nuclear translocation in all SDHB-metastatic tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We have identified the first pathway that distinguishes SDHB-metastatic from all other types of pheochromocytomas\/paragangliomas and suggest that activation of the EMT process might play a critical role in the particularly invasive phenotype of this group of tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2011-3437","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T00:29:17Z","timestamp":1333585757000},"page":"E954-E962","source":"Crossref","is-referenced-by-count":107,"title":["Epithelial to Mesenchymal Transition Is Activated in Metastatic Pheochromocytomas and Paragangliomas Caused by SDHB Gene Mutations"],"prefix":"10.1210","volume":"97","author":[{"given":"C\u00e9line","family":"Loriot","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"Universit\u00e9 Paris Diderot (C.L.), Sorbonne Paris Cit\u00e9, F-75205, Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Burnichon","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Paris Cardiovascular Research Center, and Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de G\u00e9n\u00e9tique (N.B., X.J., A.-P.G.-R.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Gadessaud","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Vescovo","sequence":"first","affiliation":[{"name":"Programme Cartes d'Identit\u00e9 des Tumeurs (L.V.), Ligue Nationale Contre Le Cancer, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Amar","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Service d'Hypertension Art\u00e9rielle (L.A., P.-F.P.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Lib\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"INSERM Unit\u00e9 1016 (R.L., J.B.), Centre National de la Recherche Scientifique UMR8104, D\u00e9partement d'Endocrinologie, M\u00e9tabolisme and Cancer, Institut Cochin"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (R.L., J.B.), H\u00f4pital Cochin, Centre de R\u00e9f\u00e9rence Maladies Rares de la Surr\u00e9nale, Service des Maladies Endocriniennes et M\u00e9taboliques"},{"name":"Rare Adrenal Cancer Network-Cortico M\u00e9dullosurr\u00e9nale Tumeur Endocrine (R.L., J.B., P.-F.P., A.-P.G.-R.), Institut National du Cancer, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bertherat","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"INSERM Unit\u00e9 1016 (R.L., J.B.), Centre National de la Recherche Scientifique UMR8104, D\u00e9partement d'Endocrinologie, M\u00e9tabolisme and Cancer, Institut Cochin"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (R.L., J.B.), H\u00f4pital Cochin, Centre de R\u00e9f\u00e9rence Maladies Rares de la Surr\u00e9nale, Service des Maladies Endocriniennes et M\u00e9taboliques"},{"name":"Rare Adrenal Cancer Network-Cortico M\u00e9dullosurr\u00e9nale Tumeur Endocrine (R.L., J.B., P.-F.P., A.-P.G.-R.), Institut National du Cancer, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Plouin","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Service d'Hypertension Art\u00e9rielle (L.A., P.-F.P.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"Rare Adrenal Cancer Network-Cortico M\u00e9dullosurr\u00e9nale Tumeur Endocrine (R.L., J.B., P.-F.P., A.-P.G.-R.), Institut National du Cancer, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jeunemaitre","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Paris Cardiovascular Research Center, and Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de G\u00e9n\u00e9tique (N.B., X.J., A.-P.G.-R.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Paule","family":"Gimenez-Roqueplo","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Paris Cardiovascular Research Center, and Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de G\u00e9n\u00e9tique (N.B., X.J., A.-P.G.-R.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"Rare Adrenal Cancer Network-Cortico M\u00e9dullosurr\u00e9nale Tumeur Endocrine (R.L., J.B., P.-F.P., A.-P.G.-R.), Institut National du Cancer, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Favier","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 970 (C.L., N.B., N.G., L.A., P.-F.P., X.J., A.-P.G.-R., J.F.), F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes (C.L., N.B., L.A., R.L., J.B., P.-F.P., X.J., A.-P.G.-R., J.F.), Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020022710294078300_B1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1440-1681.2008.04881.x","article-title":"Recent advances in the genetics of phaeochromocytoma and functional paraganglioma.","volume":"35","author":"Gimenez-Roqueplo","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2020022710294078300_B2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/363458a0","article-title":"Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature"},{"key":"2020022710294078300_B3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.2134734","article-title":"Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.","volume":"249","author":"Wallace","year":"1990","journal-title":"Science"},{"key":"2020022710294078300_B4","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene.","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"2020022710294078300_B5","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","article-title":"SDHA is a tumor suppressor gene causing paraganglioma.","volume":"19","author":"Burnichon","year":"2010","journal-title":"Hum Mol Genet"},{"key":"2020022710294078300_B6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.","volume":"69","author":"Astuti","year":"2001","journal-title":"Am J Hum Genet"},{"key":"2020022710294078300_B7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/81551","article-title":"Mutations in SDHC cause autosomal dominant paraganglioma, type 3.","volume":"26","author":"Niemann","year":"2000","journal-title":"Nat Genet"},{"key":"2020022710294078300_B8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"key":"2020022710294078300_B9","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1175689","article-title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.","volume":"325","author":"Hao","year":"2009","journal-title":"Science"},{"key":"2020022710294078300_B10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ng.533","article-title":"Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.","volume":"42","author":"Qin","year":"2010","journal-title":"Nat Genet"},{"key":"2020022710294078300_B11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.","volume":"43","author":"Comino-M\u00e9ndez","year":"2011","journal-title":"Nat Genet"},{"key":"2020022710294078300_B12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1677\/ERC-07-0074","article-title":"The diagnosis and management of malignant phaeochromocytoma and paraganglioma.","volume":"14","author":"Chrisoulidou","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"2020022710294078300_B13","article-title":"Adrenal tumours: introduction","volume-title":"World Health Organization classification of tumours: pathology and genetics: tumours of endocrine organs","author":"Lloyd","year":"2004"},{"key":"2020022710294078300_B14","first-page":"5615","article-title":"Mutations in the SDHB gene are associated with extra-adrenal and\/or malignant phaeochromocytomas.","volume":"63","author":"Gimenez-Roqueplo","year":"2003","journal-title":"Cancer Res"},{"key":"2020022710294078300_B15","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2007-0709","article-title":"Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas.","volume":"92","author":"Amar","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2020022710294078300_B16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrc1886","article-title":"Metastasis: a question of life or death.","volume":"6","author":"Mehlen","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"2020022710294078300_B17","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1098\/rstb.2007.2252","article-title":"Molecular analysis of neural crest migration.","volume":"363","author":"Kuriyama","year":"2008","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2020022710294078300_B18","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.4161\/cc.4.12.2224","article-title":"Switching on-off Snail: LOXL2 versus GSK3\u03b2.","volume":"4","author":"Peinado","year":"2005","journal-title":"Cell Cycle"},{"key":"2020022710294078300_B19","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1158\/0008-5472.CAN-05-3719","article-title":"Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.","volume":"66","author":"Krishnamachary","year":"2006","journal-title":"Cancer Res"},{"key":"2020022710294078300_B20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"2020022710294078300_B21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-4658.2010.07919.x","article-title":"Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.","volume":"278","author":"Gialeli","year":"2011","journal-title":"FEBS J"},{"key":"2020022710294078300_B22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"2020022710294078300_B23","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.200601018","article-title":"The epithelial-mesenchymal transition: new insights in signaling, development, and disease.","volume":"172","author":"Lee","year":"2006","journal-title":"J Cell Biol"},{"key":"2020022710294078300_B24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrm3068","article-title":"Adhesion molecule signalling: not always a sticky business.","volume":"12","author":"Cavallaro","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2020022710294078300_B25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrc3051","article-title":"Desmosomes: new perpetrators in tumour suppression.","volume":"11","author":"Dusek","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"2020022710294078300_B26","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1245\/s10434-009-0480-y","article-title":"Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas.","volume":"16","author":"Waldmann","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"2020022710294078300_B27","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1677\/ERC-09-0049","article-title":"High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma.","volume":"16","author":"H\u00e4yry","year":"2009","journal-title":"Endocr Relat Cancer"},{"key":"2020022710294078300_B28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis.","volume":"10","author":"Yang","year":"2008","journal-title":"Nat Cell Biol"},{"key":"2020022710294078300_B29","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","article-title":"Lysyl oxidase is essential for hypoxia-induced metastasis.","volume":"440","author":"Erler","year":"2006","journal-title":"Nature"},{"key":"2020022710294078300_B30","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.beem.2010.10.004","article-title":"Pheochromocytomas: the (pseudo)-hypoxic hypothesis.","volume":"24","author":"Favier","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2020022710294078300_B31","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1093\/hmg\/ddr324","article-title":"Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma.","volume":"20","author":"Burnichon","year":"2011","journal-title":"Hum Mol Genet"},{"key":"2020022710294078300_B32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.beem.2006.07.004","article-title":"Initial work-up and long-term follow-up in patients with phaeochromocytomas and paragangliomas.","volume":"20","author":"Plouin","year":"2006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2020022710294078300_B33","doi-asserted-by":"crossref","first-page":"E1472","DOI":"10.1210\/jc.2011-1043","article-title":"SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas.","volume":"96","author":"Korpershoek","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2020022710294078300_B34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2164-7-51","article-title":"Comparison of the latest commercial short and long oligonucleotide microarray technologies.","volume":"7","author":"de Reyni\u00e8s","year":"2006","journal-title":"BMC Genomics"},{"key":"2020022710294078300_B35","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics.","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"2020022710294078300_B36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data.","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2020022710294078300_B37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1385\/EP:13:2:099","article-title":"N-cadherin expression in adrenal tumors: upregulation in malignant pheochromocytoma and downregulation in adrenocortical carcinoma.","volume":"13","author":"Khorram-Manesh","year":"2002","journal-title":"Endocr Pathol"},{"key":"2020022710294078300_B38","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1093\/hmg\/ddi359","article-title":"Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.","volume":"14","author":"Bri\u00e8re","year":"2005","journal-title":"Hum Mol Genet"},{"key":"2020022710294078300_B39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ccr.2005.07.009","article-title":"The transcriptional repressor Snail promotes mammary tumor recurrence.","volume":"8","author":"Moody","year":"2005","journal-title":"Cancer Cell"},{"key":"2020022710294078300_B40","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/sj.bjc.6604755","article-title":"Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival.","volume":"99","author":"Waldmann","year":"2008","journal-title":"Br J Cancer"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/6\/E954\/32677430\/jceme954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/6\/E954\/32677430\/jceme954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T10:29:56Z","timestamp":1582799396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/97\/6\/E954\/2536900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2011-3437","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,1]]}}}