{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:07:58Z","timestamp":1793012878958,"version":"4.5.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":1618,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/us\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>In contrast to the many studies in females, there are few data in males on the relationships between childhood growth and weight gain and the timing of pubertal maturation and its relevance to adult body mass index (BMI) and body composition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A total of 2008 males in the 1946 British Birth Cohort Study had assessment of pubertal status including voice-breaking status (no change, starting, or complete) at age 14 yr. These responses were related to growth measurements at birth (weight only) and at 2, 4, 6, 7, 11, 14, 20, 26, 36, 43, 53, and 60\u201364 yr. Body composition was assessed by dual-energy x-ray absorptiometry at 60\u201364 yr.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Males with more advanced voice-breaking status at age 14 yr had similar birth weights compared with other males; they showed faster weight gain from 0\u20132 yr and had higher mean weight and BMI at age 2 yr. Subsequently, they continued to accelerate in weight and BMI, and also in height, and maximum differences in body size were seen at age 14 yr. Adult height did not differ between groups, but males with advanced voice breaking had higher adult BMI and greater whole-body lean mass and greater android fat mass at 60\u201364 yr.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Similar to females with earlier menarche, the trajectory to earlier sexual maturation in males is manifested by faster early postnatal growth and weight gain and leads to higher adult BMI. Timing of pubertal maturation has potential relevance to adult disease risks in males. We also describe conditional height difference in sd score as a proxy marker of pubertal timing in males.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2011-3445","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T23:51:40Z","timestamp":1338508300000},"page":"2844-2852","source":"Crossref","is-referenced-by-count":51,"title":["Timing of Voice Breaking in Males Associated with Growth and Weight Gain Across the Life Course"],"prefix":"10.1210","volume":"97","author":[{"given":"Ken K.","family":"Ong","sequence":"first","affiliation":[{"name":"Medical Research Council (MRC) Unit for Lifelong Health and Ageing (K.K.O., D.B., A.K.W., R.H., D.K.), London WC1B 5JU, United Kingdom"},{"name":"MRC Epidemiology Unit (K.K.O.), Institute of Metabolic Science, Addenbrooke's Hospital, Box 285, Cambridge CB2 0QQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bann","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Unit for Lifelong Health and Ageing (K.K.O., D.B., A.K.W., R.H., D.K.), London WC1B 5JU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Wills","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Unit for Lifelong Health and Ageing (K.K.O., D.B., A.K.W., R.H., D.K.), London WC1B 5JU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Ward","sequence":"additional","affiliation":[{"name":"MRC Human Nutrition Research (K.W.), Elsie Widdowson Laboratory, Cambridge CB1 9NL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Imaging Science and Biomedical Engineering (J.E.A.), University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hardy","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Unit for Lifelong Health and Ageing (K.K.O., D.B., A.K.W., R.H., D.K.), London WC1B 5JU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kuh","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Unit for Lifelong Health and Ageing (K.K.O., D.B., A.K.W., R.H., D.K.), London WC1B 5JU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the National Survey of Health and Development Scientific and Data Collection 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