{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:09:04Z","timestamp":1774422544782,"version":"3.50.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Fibroblast growth factor (FGF)-23, secreted from osteocytes\/osteoblasts, plays major roles in phosphate (Pi)-mediated stimulation of PTH secretion and consequently in regulation of serum Pi. Osteocyte\/osteoblast dysfunction develops in patients with type 2 diabetes mellitus (DM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Our objective was to examine whether increases in serum FGF-23 and PTH after oral Pi stimulation are impaired in type 2 DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Methods:<\/jats:title>\n                  <jats:p>The subjects were 10 DM and 10 non-DM patients without chronic kidney disease stage 3\u20135. Serum FGF-23, intact PTH (iPTH), and Pi were measured serially after oral Pi administration at a daily dose of 2.0 g.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Pi administration caused significant increases of FGF-23 by 2 h and iPTH by 4 h in non-DM patients. These increases were attenuated in DM patients. After 2 d of Pi stimulation, serum FGF-23 and iPTH remained elevated in non-DM patients but not in DM. In all subjects, initial changes of serum FGF-23 (0\u20132 h) and iPTH (0\u20134 h) were positively correlated (r = 0.528) and showed significant negative correlations with later changes in serum Pi (2\u20134 h) (r = \u22120.457 and r = \u22120.673, respectively). Serum Pi (2\u20134 h) significantly increased in DM patients, consistent with the lack of change in serum FGF-23 and iPTH, whereas serum Pi did not change significantly in non-DM patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>These results show that increases of serum FGF-23 and PTH in response to Pi stimulation are impaired in type 2 DM and that serum Pi is significantly increased thereafter. This may be a mechanism underlying advanced atherosclerosis in type 2 DM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2012-2024","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T18:55:14Z","timestamp":1352141714000},"page":"E2036-E2043","source":"Crossref","is-referenced-by-count":28,"title":["Impaired Response of FGF-23 to Oral Phosphate in Patients with Type 2 Diabetes: A Possible Mechanism of Atherosclerosis"],"prefix":"10.1210","volume":"97","author":[{"given":"Koichiro","family":"Yoda","sequence":"first","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Ichii","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhito","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Emoto","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071615524061200_B1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1359\/jbmr.070510","article-title":"Osteoporosis in patients with diabetes mellitus.","volume":"22","author":"Hofbauer","year":"2007","journal-title":"J Bone Miner Res"},{"key":"2020071615524061200_B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.diabres.2004.08.006","article-title":"Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor\/osteoprotegerin (OCIF\/OPG) on the decrease of bone mineral density.","volume":"68","author":"Suzuki","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"2020071615524061200_B3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S8756-3282(97)00220-2","article-title":"Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells.","volume":"22","author":"Terada","year":"1998","journal-title":"Bone"},{"key":"2020071615524061200_B4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/jbmr.5650100709","article-title":"Influence of high glucose on 1,25-dihydroxyvitamin D3-induced effect on human osteoblast-like MG-63 cells.","volume":"10","author":"Inaba","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2020071615524061200_B5","first-page":"201","article-title":"Impaired response of human osteosarcoma (MG-63) cells to human parathyroid hormone induced by sustained exposure to high glucose.","volume":"21","author":"Yoshida","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"2020071615524061200_B6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bone.2004.06.014","article-title":"Bone as a source of FGF23: regulation by phosphate?","volume":"35","author":"Mirams","year":"2004","journal-title":"Bone"},{"key":"2020071615524061200_B7","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.bone.2007.01.017","article-title":"Mineralized tissue cells are a principal source of FGF23.","volume":"40","author":"Yoshiko","year":"2007","journal-title":"Bone"},{"key":"2020071615524061200_B8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.amjmed.2008.09.039","article-title":"Serum phosphorus and cardiovascular mortality in type 2 diabetes.","volume":"122","author":"Chonchol","year":"2009","journal-title":"Am J Med"},{"key":"2020071615524061200_B9","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1007\/s00198-006-0154-6","article-title":"Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients.","volume":"17","author":"Inaba","year":"2006","journal-title":"Osteoporos Int"},{"key":"2020071615524061200_B10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000420146","article-title":"Parathyroid hormone secretion in diabetes mellitus.","volume":"90","author":"Kawagishi","year":"1991","journal-title":"Contrib Nephrol"},{"key":"2020071615524061200_B11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/ajkd.2002.33400","article-title":"Impaired secretion of parathyroid hormone, but not refractoriness of osteoblast, is a major mechanism of low bone turnover in hemodialyzed patients with diabetes mellitus.","volume":"39","author":"Inaba","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"2020071615524061200_B12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ki.2010.313","article-title":"Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.","volume":"78","author":"Hasegawa","year":"2010","journal-title":"Kidney Int"},{"key":"2020071615524061200_B13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.2040-1124.2010.00074.x","article-title":"Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus.","volume":"1","author":"Seino","year":"2010","journal-title":"J Diabetes Invest"},{"key":"2020071615524061200_B14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.5650070215","article-title":"A new sensitive homologous radioimmunoassay for amino-terminal parathyroid hormone in the rat.","volume":"7","author":"Finch","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2020071615524061200_B15","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1210\/jc.2002-021105","article-title":"Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets\/osteomalacia.","volume":"87","author":"Yamazaki","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615524061200_B16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s001980050180","article-title":"Poor glycemic control impairs the response of biochemical parameters of bone formation and resorption to exogenous 1,25-dihydroxyvitamin D3 in patients with type 2 diabetes.","volume":"9","author":"Inaba","year":"1999","journal-title":"Osteoporos Int"},{"key":"2020071615524061200_B17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/clinchem\/45.4.526","article-title":"Immunoradiometric assay for intact human osteocalcin(1\u201349) without cross-reactivity to breakdown products.","volume":"45","author":"Colford","year":"1999","journal-title":"Clin Chem"},{"key":"2020071615524061200_B18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1053\/j.ajkd.2007.09.004","article-title":"Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan.","volume":"50","author":"Imai","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"2020071615524061200_B19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.2040-1124.2012.00207.x","article-title":"International clinical harmonization of hemoglobin A1c in Japan: from JDS to NGSP values.","volume":"3","author":"Kashiwagi","year":"2012","journal-title":"J Diabetes Invest"},{"key":"2020071615524061200_B20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/diabetes.52.2.448","article-title":"Preferential stiffening of central over peripheral arteries in type 2 diabetes.","volume":"52","author":"Kimoto","year":"2003","journal-title":"Diabetes"},{"key":"2020071615524061200_B21","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1161\/01.RES.87.7.e10","article-title":"Phosphate regulation of vascular smooth muscle cell calcification.","volume":"87","author":"Jono","year":"2000","journal-title":"Circ Res"},{"key":"2020071615524061200_B22","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1053\/ajkd.2001.27396","article-title":"Monckeberg's medial sclerosis and inorganic phosphate in uremia.","volume":"38","author":"Shioi","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"2020071615524061200_B23","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1161\/01.ATV.20.8.1926","article-title":"Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study.","volume":"20","author":"Hak","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071615524061200_B24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.ajkd.2004.04.029","article-title":"Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency.","volume":"44","author":"Shigematsu","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"2020071615524061200_B25","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2005010052","article-title":"Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease.","volume":"16","author":"Gutierrez","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2020071615524061200_B26","first-page":"23","article-title":"Influence of short-term diabetes on osteocytic lacunae of alveolar bone. A histomorphometric study.","volume":"19","author":"Villarino","year":"2006","journal-title":"Acta Odontol Latinoam"},{"key":"2020071615524061200_B27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-\u03baB.","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071615524061200_B28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bone.2006.09.011","article-title":"Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.","volume":"40","author":"Alikhani","year":"2007","journal-title":"Bone"},{"key":"2020071615524061200_B29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jcb.20777","article-title":"Playing with bone and fat.","volume":"98","author":"Gimble","year":"2006","journal-title":"J Cell Biochem"},{"key":"2020071615524061200_B30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton.","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"2020071615524061200_B31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/MAJ.0b013e3181db6dfe","article-title":"Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis.","volume":"339","author":"Kanazawa","year":"2010","journal-title":"Am J Med Sci"},{"key":"2020071615524061200_B32","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1210\/jc.2004-1039","article-title":"Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men.","volume":"90","author":"Ferrari","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615524061200_B33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2215\/CJN.04730510","article-title":"Effects of dietary phosphate and calcium intake on fibroblast growth factor-23.","volume":"6","author":"Vervloet","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2020071615524061200_B34","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.lfs.2011.11.006","article-title":"Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients.","volume":"90","author":"Kobayashi","year":"2012","journal-title":"Life Sci"},{"key":"2020071615524061200_B35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00223-008-9206-6","article-title":"Association of reduction in bone mineral density with mortality in male hemodialysis patients.","volume":"84","author":"Kohno","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"2020071615524061200_B36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1523-1755.2005.00184.x","article-title":"Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients.","volume":"67","author":"Nakanishi","year":"2005","journal-title":"Kidney Int"},{"key":"2020071615524061200_B37","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1093\/ndt\/gfp205","article-title":"Relationship between circulating FGF23 and total body atherosclerosis in the community.","volume":"24","author":"Mirza","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2020071615524061200_B38","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis.","volume":"359","author":"Guti\u00e9rrez","year":"2008","journal-title":"N Engl J Med"},{"key":"2020071615524061200_B39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5551\/jat.5595","article-title":"Serum fibroblast growth factor-23 levels and progression of aortic arch calcification in non-diabetic patients on chronic hemodialysis.","volume":"18","author":"Tamei","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"2020071615524061200_B40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease.","volume":"22","author":"Hu","year":"2011","journal-title":"J Am Soc Nephrol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/11\/E2036\/10745420\/jcem2036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/11\/E2036\/10745420\/jcem2036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:56:43Z","timestamp":1594954603000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/97\/11\/E2036\/2836251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-2024","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,1]]}}}