{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:58:56Z","timestamp":1774641536664,"version":"3.50.1"},"reference-count":10,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Magnesium is involved in the homeostasis of calcium metabolism, and magnesium deficiency may lead to clinically significant hypocalcemia. We have had two cases in our department in which treated hypoparathyroid patients with stable calcium levels developed hypercalcemia in conjunction with supplementary magnesium use. To our knowledge, there has been no prospective study looking at the effect of supplementary magnesium on calcium homeostasis in hypoparathyroid patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The aim of this pilot study was to evaluate whether magnesium treatment affects plasma calcium levels in hypoparathyroid patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting:<\/jats:title>\n                  <jats:p>We conducted a prospective, two-phase, uncontrolled treatment trial at a referral center of endocrine disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>We enrolled treated (calcium + vitamin D analog) hypoparathyroid patients with normal plasma magnesium levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention:<\/jats:title>\n                  <jats:p>Three weeks of treatment with oral magnesium (350 mg\/d) were followed by 2 wk off treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Measures:<\/jats:title>\n                  <jats:p>We compared the plasma ionized calcium level after 3 wk of treatment to the pretreatment value. Plasma calcium, phosphate, magnesium, and creatinine levels were measured before treatment, after 3 wk on magnesium, and 2 wk after stopping magnesium treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Ten patients completed the trial. Supplementary treatment with magnesium for 3 wk did not change calcium levels in these patients. Magnesium supplementation induced a small but statistically significant increase in the plasma magnesium level, but levels of phosphate and creatinine remained stable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Magnesium supplementation did not influence plasma calcium levels in treated hypoparathyroid patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2012-2301","type":"journal-article","created":{"date-parts":[[2012,9,8]],"date-time":"2012-09-08T05:00:50Z","timestamp":1347080450000},"page":"E2090-E2092","source":"Crossref","is-referenced-by-count":6,"title":["Magnesium Supplementation Does Not Affect Blood Calcium Level in Treated Hypoparathyroid Patients"],"prefix":"10.1210","volume":"97","author":[{"given":"Maire","family":"Lubi","sequence":"first","affiliation":[{"name":"Endocrinology Unit (M.L., K.T., S.M., V.V.), Hospital of Internal Medicine, Tartu University Hospital, 51014 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaia","family":"Tammiksaar","sequence":"additional","affiliation":[{"name":"Endocrinology Unit (M.L., K.T., S.M., V.V.), Hospital of Internal Medicine, Tartu University Hospital, 51014 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Matjus","sequence":"additional","affiliation":[{"name":"Endocrinology Unit (M.L., K.T., S.M., V.V.), Hospital of Internal Medicine, Tartu University Hospital, 51014 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Vasar","sequence":"additional","affiliation":[{"name":"Department of Physiology (E.V., V.V.), Tartu University, 50411 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vallo","family":"Volke","sequence":"additional","affiliation":[{"name":"Endocrinology Unit (M.L., K.T., S.M., V.V.), Hospital of Internal Medicine, Tartu University Hospital, 51014 Tartu, Estonia"},{"name":"Department of Physiology (E.V., V.V.), Tartu University, 50411 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071616070430700_B1","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1210\/jc.2002-021736","article-title":"Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium.","volume":"88","author":"Winer","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616070430700_B2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1210\/jc.2007-2552","article-title":"Effects of once versus twice-daily parathyroid hormone 1-34 therapy in children with hypoparathyroidism.","volume":"93","author":"Winer","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616070430700_B3","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1210\/jc.2009-2464","article-title":"Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium.","volume":"95","author":"Winer","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616070430700_B4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1210\/jcem-73-5-1067","article-title":"Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism.","volume":"73","author":"Fatemi","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616070430700_B5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1651-2227.1971.tb06684.x","article-title":"Chronic hypomagnesemia with magnesium-dependent hypocalcemia. 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