{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:06:19Z","timestamp":1792065979102,"version":"4.4.0"},"reference-count":33,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"DOI":"10.1210\/jc.2012-2468","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T02:56:36Z","timestamp":1358823396000},"page":"E429-E436","source":"Crossref","is-referenced-by-count":66,"title":["Placental Specific mRNA in the Maternal Circulation Are Globally Dysregulated in Pregnancies Complicated by Fetal Growth Restriction"],"prefix":"10.1210","volume":"98","author":[{"given":"Clare L.","family":"Whitehead","sequence":"first","affiliation":[{"name":"Translational Obstetrics Group (C.W., L.Y., T.J.K.-L., S.T.), Department of Obstetrics and Gynecology, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (S.P.W., S.M., M.L.), University of Melbourne, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louie","family":"Ye","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group (C.W., L.Y., T.J.K.-L., S.T.), Department of Obstetrics and Gynecology, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Mendis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (S.P.W., S.M., M.L.), University of Melbourne, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu'uhevaha J.","family":"Kaitu'u-Lino","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group (C.W., L.Y., T.J.K.-L., S.T.), Department of Obstetrics and Gynecology, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Lappas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (S.P.W., S.M., M.L.), University of Melbourne, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tong","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group (C.W., L.Y., T.J.K.-L., S.T.), Department of Obstetrics and Gynecology, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113432738700_B1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bpobgyn.2009.08.011","article-title":"Obstetric management of intrauterine growth restriction","volume":"23","author":"Marsal","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113432738700_B2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(07)61723-1","article-title":"Stillbirth","volume":"370","author":"Smith","year":"2007","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113432738700_B3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.0001-6349.2004.00602.x","article-title":"Restricted fetal growth in sudden intrauterine unexplained death","volume":"83","author":"Froen","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113432738700_B4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0378-3782(81)90017-7","article-title":"Perinatal morbidity and mortality in small-for-dates babies: the relative importance of some maternal factors","volume":"5","author":"Ounsted","year":"1981","journal-title":"Early Hum Dev"},{"key":"key\n\t\t\t\t2019041113432738700_B5","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0140-6736(11)60064-0","article-title":"Stillbirths: the way forward in high-income countries","volume":"377","author":"Flenady","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113432738700_B6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113432738700_B7","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/clinchem\/46.11.1832","article-title":"Presence of fetal RNA in maternal plasma","volume":"46","author":"Poon","year":"2000","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113432738700_B8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/jmg.2003.016881","article-title":"Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling","volume":"41","author":"Tsui","year":"2004","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t2019041113432738700_B9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/humupd\/dmq054","article-title":"Non-invasive aneuploidy detection using free fetal DNA and RNA in maternal plasma: recent progress and future possibilities","volume":"17","author":"Go","year":"2011","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t2019041113432738700_B10","first-page":"159","article-title":"ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002","volume":"99","author":"ACOG Committee on Practice Bulletins\u2013Obstetrics","year":"2002","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113432738700_B11","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1210\/jc.2011-1233","article-title":"Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia","volume":"96","author":"Paiva","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113432738700_B12","first-page":"23","article-title":"Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review)","volume":"6","author":"Gourvas","year":"2012","journal-title":"Mol Med Report"},{"key":"key\n\t\t\t\t2019041113432738700_B13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1515\/jpm.2010.041","article-title":"Fetal growth restriction\u2014from observation to intervention","volume":"38","author":"Baschat","year":"2010","journal-title":"J Perinat Med"},{"key":"key\n\t\t\t\t2019041113432738700_B14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1471-0528.1977.tb12676.x","article-title":"Fetal growth retardation and the arteries of the placental bed","volume":"84","author":"Brosens","year":"1977","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113432738700_B15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0002-9378(97)70438-1","article-title":"Placental apoptosis in normal human pregnancy","volume":"177","author":"Smith","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113432738700_B16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1196\/annals.1448.017","article-title":"Phenotype and mRNA expression of syncytiotrophoblast microparticles isolated from human placenta","volume":"1137","author":"Kumpel","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"key\n\t\t\t\t2019041113432738700_B17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/HYPERTENSIONAHA.111.182170","article-title":"Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"59","author":"Rajakumar","year":"2012","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113432738700_B18","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/MCB.23.10.3566-3574.2003","article-title":"Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation","volume":"23","author":"Frendo","year":"2003","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041113432738700_B19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00109-010-0656-8","article-title":"Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes","volume":"88","author":"Ruebner","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"key\n\t\t\t\t2019041113432738700_B20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nm1530","article-title":"Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection","volume":"13","author":"Lo","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113432738700_B21","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/jcem.87.4.8430","article-title":"Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth","volume":"87","author":"Smith","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113432738700_B22","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1210\/jc.2009-2277","article-title":"Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability","volume":"95","author":"Yan","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113432738700_B23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1677\/JOE-09-0136","article-title":"Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse","volume":"202","author":"Wang","year":"2009","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113432738700_B24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1210\/en.2006-0818","article-title":"Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels","volume":"148","author":"Mead","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113432738700_B25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2265.2009.03659.x","article-title":"Microarray analysis of placental tissue in intrauterine growth restriction","volume":"72","author":"Struwe","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113432738700_B26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ajog.2004.06.070","article-title":"Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigation","volume":"191","author":"Wadhwa","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113432738700_B27","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(77)92154-7","article-title":"Pregnancy-specific \u03b21-glycoprotein in early pregnancy","volume":"1","author":"Horne","year":"1977","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113432738700_B28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1471-0528.1977.tb12674.x","article-title":"Circulating levels of pregnancy-specific \u03b21-glycoprotein and human placental lactogen in the third trimester of pregnancy: their relationship to parity, birth weight, and placental weight","volume":"84","author":"Gordon","year":"1977","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113432738700_B29","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1210\/jc.2010-0023","article-title":"Differential expression profile of growth hormone\/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns","volume":"95","author":"Mannik","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113432738700_B30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/pd.2230","article-title":"A strategy for identifying circulating placental RNA markers for fetal growth assessment","volume":"29","author":"Pang","year":"2009","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113432738700_B31","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/pd.2328","article-title":"Decreased serum levels of kisspeptin in early pregnancy are associated with intra-uterine growth restriction and pre-eclampsia","volume":"29","author":"Armstrong","year":"2009","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113432738700_B32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/pd.1969","article-title":"Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates","volume":"28","author":"Smets","year":"2008","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113432738700_B33","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/35015579","article-title":"Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia","volume":"405","author":"Page","year":"2000","journal-title":"Nature"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/3\/E429\/10421112\/jcemE429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T22:50:29Z","timestamp":1595285429000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/3\/E429\/2536864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-2468","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}