{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:54:36Z","timestamp":1756994076233},"reference-count":40,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"DOI":"10.1210\/jc.2012-2642","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T15:03:46Z","timestamp":1348758226000},"page":"4761-4768","source":"Crossref","is-referenced-by-count":31,"title":["Patients with an HbA1c in the Prediabetic and Diabetic Range Have Higher Numbers of Circulating Cells with Osteogenic and Endothelial Progenitor Cell Markers"],"prefix":"10.1210","volume":"97","author":[{"given":"Andreas J.","family":"Flammer","sequence":"first","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"G\u00f6ssl","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Reriani","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Simari","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension (L.O.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit (S.K.), Mayo Clinic and College of Medicine, Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases (A.J.F., M.G., J.L., Y.M., M.R., D.L., R.D.S., A.L.), Rochester, Minnesota 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113232325900_B1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/bmj.38678.389583.7C","article-title":"Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies.","volume":"332","author":"Huxley","year":"2006","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113232325900_B2","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1001\/archinte.164.19.2147","article-title":"Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies.","volume":"164","author":"Levitan","year":"2004","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113232325900_B3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/HJR.0b013e32833b0932","article-title":"HbA1c is an independent predictor of non-fatal cardiovascular disease in a Caucasian population without diabetes: a 10-year follow-up of the Hoorn Study.","volume":"19","author":"van 't Riet","year":"2012","journal-title":"Eur J Prev Cardiol"},{"key":"key\n\t\t\t\t2019041113232325900_B4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications.","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113232325900_B5","doi-asserted-by":"crossref","first-page":"C13","DOI":"10.1016\/j.jacc.2005.10.065","article-title":"Pathology of the vulnerable plaque.","volume":"47","author":"Virmani","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041113232325900_B6","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jacc.2009.10.060","article-title":"Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence.","volume":"55","author":"Ford","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041113232325900_B7","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1016\/j.atherosclerosis.2007.05.025","article-title":"High-normal fasting blood glucose in non-diabetic range is associated with increased coronary artery calcium burden in asymptomatic men.","volume":"195","author":"Nasir","year":"2007","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113232325900_B8","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1161\/CIRCULATIONAHA.112.090860","article-title":"Emerging role of circulating calcifying cells in the bone-vascular axis.","volume":"125","author":"Fadini","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113232325900_B9","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa044264","article-title":"Circulating osteoblast-lineage cells in humans.","volume":"352","author":"Eghbali-Fatourechi","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113232325900_B10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/cvr\/cvn081","article-title":"Vascular repair by endothelial progenitor cells.","volume":"78","author":"Zampetaki","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019041113232325900_B11","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1161\/01.RES.0000205765.28940.93","article-title":"CD34\u2212\/CD133+\/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities.","volume":"98","author":"Friedrich","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113232325900_B12","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2008.07.019","article-title":"Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis.","volume":"52","author":"G\u00f6ssl","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041113232325900_B13","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/eurheartj\/ehq373","article-title":"Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells.","volume":"31","author":"G\u00f6ssl","year":"2010","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041113232325900_B14","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehs234","article-title":"Osteocalcin positive CD133+\/CD34\u2212\/KDR+ progenitor cells as an independent marker for unstable atherosclerosis","author":"Flammer","year":"2012","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041113232325900_B15","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1161\/CIRCRESAHA.110.234088","article-title":"Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes.","volume":"108","author":"Fadini","year":"2011","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113232325900_B16","doi-asserted-by":"crossref","first-page":"921685","DOI":"10.1155\/2012\/921685","article-title":"Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease.","volume":"2012","author":"Fadini","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"key\n\t\t\t\t2019041113232325900_B17","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus.","volume":"33","author":"Association","year":"2010","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113232325900_B18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa043814","article-title":"Circulating endothelial progenitor cells and cardiovascular outcomes.","volume":"353","author":"Werner","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113232325900_B19","article-title":"Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells","author":"Flammer","year":"2012","journal-title":"Eur J Nutr"},{"key":"key\n\t\t\t\t2019041113232325900_B20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","article-title":"The regulation of valvular and vascular sclerosis by osteogenic morphogens.","volume":"109","author":"Bostr\u00f6m","year":"2011","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113232325900_B21","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.2353\/ajpath.2006.060064","article-title":"Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing.","volume":"169","author":"Matsumoto","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019041113232325900_B22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1634\/stemcells.2004-0330","article-title":"Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity.","volume":"23","author":"Tondreau","year":"2005","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t2019041113232325900_B23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease.","volume":"13","author":"Zaidi","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113232325900_B24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00198-008-0648-5","article-title":"Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?","volume":"20","author":"Anagnostis","year":"2009","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113232325900_B25","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1359\/jbmr.080504","article-title":"Abdominal aortic calcification, BMD, and bone microstructure: a population-based study.","volume":"23","author":"Chow","year":"2008","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113232325900_B26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00198-006-0282-z","article-title":"Vascular calcification and osteoporosis\u2014from clinical observation towards molecular understanding.","volume":"18","author":"Hofbauer","year":"2007","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113232325900_B27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1359\/jbmr.060104","article-title":"High bone turnover is an independent predictor of mortality in the frail elderly.","volume":"21","author":"Sambrook","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113232325900_B28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2353\/ajpath.2010.090758","article-title":"Myeloid CD34+CD13+ precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification.","volume":"177","author":"Doehring","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019041113232325900_B29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.atherosclerosis.2009.11.001","article-title":"Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.","volume":"210","author":"Pal","year":"2010","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113232325900_B30","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1253\/circj.CJ-10-1056","article-title":"Circulating concentrations of stem-cell-mobilizing cytokines are associated with levels of osteoprogenitor cells and aortic calcification severity.","volume":"75","author":"Pal","year":"2011","journal-title":"Circ J"},{"key":"key\n\t\t\t\t2019041113232325900_B31","doi-asserted-by":"crossref","first-page":"274363","DOI":"10.1155\/2012\/274363","article-title":"Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy.","volume":"2012","author":"Fadini","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"key\n\t\t\t\t2019041113232325900_B32","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jacc.2004.11.067","article-title":"Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.","volume":"45","author":"Fadini","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041113232325900_B33","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1007\/s00125-008-0939-6","article-title":"Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes.","volume":"51","author":"Egan","year":"2008","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113232325900_B34","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1161\/01.CIR.0000039526.42991.93","article-title":"Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures.","volume":"106","author":"Tepper","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113232325900_B35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6823-10-5","article-title":"Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control.","volume":"10","author":"Churdchomjan","year":"2010","journal-title":"BMC Endocr Disord"},{"key":"key\n\t\t\t\t2019041113232325900_B36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2119\/molmed.2009.00032","article-title":"Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia.","volume":"15","author":"Loomans","year":"2009","journal-title":"Mol Med"},{"key":"key\n\t\t\t\t2019041113232325900_B37","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/aps.2011.128","article-title":"Oxidized low-density lipoprotein and \u03b2-glycerophosphate synergistically induce endothelial progenitor cell ossification.","volume":"32","author":"Liu","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"key\n\t\t\t\t2019041113232325900_B38","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: from research into clinical practice.","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113232325900_B39","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/HYPERTENSIONAHA.108.126615","article-title":"Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals.","volume":"53","author":"McEniery","year":"2009","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113232325900_B40","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.numecd.2010.01.015","article-title":"Circulating immature osteoprogenitor cells and arterial stiffening in postmenopausal osteoporosis.","volume":"21","author":"Pirro","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/97\/12\/4761\/9048708\/jcem4761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T07:47:38Z","timestamp":1562226458000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/97\/12\/4761\/2536672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-2642","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}