{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:58:37Z","timestamp":1791853117789,"version":"4.3.4"},"reference-count":60,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"DOI":"10.1210\/jc.2012-3072","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T02:12:54Z","timestamp":1360289574000},"page":"1040-1050","source":"Crossref","is-referenced-by-count":119,"title":["A Comprehensive Study of Clinical, Biochemical, Radiological, Vascular, Cardiac, and Sleep Parameters in an Unselected Cohort of Patients With Acromegaly Undergoing Presurgical Somatostatin Receptor Ligand Therapy"],"prefix":"10.1210","volume":"98","author":[{"given":"Anand K.","family":"Annamalai","sequence":"first","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Webb","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysoon","family":"Elkhawad","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit (M.E., K.M.-P., I.B.W.), Cambridge, United Kingdom CB2 0QQ"},{"name":"Departments of Cardiovascular Medicine (M.E., F.K., D.P.D.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Moir","sequence":"additional","affiliation":[{"name":"the Respiratory Support and Sleep Centre (S.M., J.M.S.), Papworth Hospital, Papworth Everard, Cambridge, United Kingdom CB23 3RE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakhar","family":"Khan","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine (M.E., F.K., D.P.D.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Maki-Petaja","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit (M.E., K.M.-P., I.B.W.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Gayton","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Strey","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaumya","family":"Ariyaratnam","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Halsall","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry (D.J.H.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afzal N.","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Renal Medicine (A.N.C.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berman","sequence":"additional","affiliation":[{"name":"Radiology (L.B., D.J.S., N.M.A.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Scoffings","sequence":"additional","affiliation":[{"name":"Radiology (L.B., D.J.S., N.M.A.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagui M.","family":"Antoun","sequence":"additional","affiliation":[{"name":"Radiology (L.B., D.J.S., N.M.A.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Dutka","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine (M.E., F.K., D.P.D.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit (M.E., K.M.-P., I.B.W.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Shneerson","sequence":"additional","affiliation":[{"name":"the Respiratory Support and Sleep Centre (S.M., J.M.S.), Papworth Hospital, Papworth Everard, Cambridge, United Kingdom CB23 3RE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[{"name":"Neurosurgery (J.D.P.), University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gurnell","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Institute of Metabolic Science (A.K.A., A.W., N.K., E.L.G., C.H.S., S.O., S.A., H.L.S., M.G.), Cambridge, United Kingdom CB2 0QQ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113383503600_B1","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113383503600_B2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","article-title":"Systemic complications of acromegaly: epidemiology, pathogenesis, and management","volume":"25","author":"Colao","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113383503600_B3","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1210\/jc.2008-2421","article-title":"Guidelines for acromegaly management: an update","volume":"94","author":"Melmed","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2265.1998.00581.x","article-title":"The outcome of surgery for acromegaly: the need for a specialist pituitary surgeon for all types of growth hormone (GH) secreting adenoma","volume":"49","author":"Lissett","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2265.1999.00760.x","article-title":"Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience","volume":"50","author":"Ahmed","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B6","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1210\/jc.2002-021822","article-title":"Transsphenoidal surgery for acromegaly in Wales: results based on stringent criteria of remission","volume":"88","author":"De","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/eje.1.01863","article-title":"The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical \u2018cure.\u2019","volume":"152","author":"Nomikos","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B8","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1210\/jcem.86.4.7398","article-title":"Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity","volume":"86","author":"Kaltsas","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B9","first-page":"1239","article-title":"Transsphenoidal surgery for acromegaly: endocrinological follow-up of 98 patients","volume":"48","author":"Shimon","year":"2001","journal-title":"Neurosurgery"},{"key":"key\n\t\t\t\t2019041113383503600_B10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-2265.2003.01679.x","article-title":"Long-term outcome and mortality after transsphenoidal adenomectomy for acromegaly","volume":"58","author":"Beauregard","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000095533","article-title":"Transsphenoidal microsurgery for newly diagnosed acromegaly: a personal view after more than 1,000 operations","volume":"83","author":"Ludecke","year":"2006","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t2019041113383503600_B12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/eje.1.01824","article-title":"Gross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs","volume":"152","author":"Petrossians","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/jc.2005-1208","article-title":"Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly","volume":"91","author":"Colao","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B14","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1365-2265.2007.03139.x","article-title":"Surgical debulking of pituitary macroadenomas causing acromegaly improves control by lanreotide","volume":"68","author":"Karavitaki","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1210\/jc.2007-1191","article-title":"Mortality in acromegaly: a metaanalysis","volume":"93","author":"Dekkers","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B16","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1210\/jc.2009-2670","article-title":"A consensus on criteria for cure of acromegaly","volume":"95","author":"Giustina","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B17","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2009-0941","article-title":"Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study","volume":"94","author":"Colao","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B18","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1210\/jcem.82.10.4283","article-title":"Effect of octreotide pretreatment on surgical outcome in acromegaly","volume":"82","author":"Colao","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B19","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3171\/jns.2006.104.6.899","article-title":"Presurgical treatment with somatostatin analogs in patients with acromegaly: effects on the remission and complication rates","volume":"104","author":"Losa","year":"2006","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t2019041113383503600_B20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00701-005-0511-9","article-title":"Presurgical octreotide treatment in acromegaly: no improvement of final growth hormone (GH) concentration and pituitary function. A long-term case-control study","volume":"147","author":"Pl\u00f6ckinger","year":"2005","journal-title":"Acta Neurochir"},{"key":"key\n\t\t\t\t2019041113383503600_B21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/eje.0.1450137","article-title":"Effects of preoperative octreotide treatment on different subtypes of 90 GH-secreting pituitary adenomas and outcome in one surgical centre","volume":"145","author":"Abe","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B22","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1210\/jcem-67-5-1040","article-title":"Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201\u2013995: shrinkage of invasive pituitary macroadenomas and improved surgical remission rate","volume":"67","author":"Barkan","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B23","first-page":"18","article-title":"Presurgical octreotide treatment in acromegaly","volume":"129","author":"Stevenaert","year":"1993","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041113383503600_B24","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1210\/jc.2008-0315","article-title":"Preoperative octreotide treatment in newly diagnosed acromegalic patients with macroadenomas increases cure short-term postoperative rates: a prospective, randomized trial","volume":"93","author":"Carlsen","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.0300-0664.2001.01438.x","article-title":"Long-term effects of lanreotide SR and octreotide LAR on tumour shrinkage and GH hypersecretion in patients with previously untreated acromegaly","volume":"56","author":"Amato","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B26","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1210\/jc.2004-1093","article-title":"The antitumoral effects of somatostatin analog therapy in acromegaly","volume":"90","author":"Bevan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B27","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1210\/jc.2001-012012","article-title":"Primary medical therapy for acromegaly: an open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on growth hormone, insulin-like growth factor-I, and tumor size","volume":"87","author":"Bevan","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B28","first-page":"2779","article-title":"Long-term effects of depot long-acting somatostatin analog octreotide on hormone levels and tumor mass in acromegaly","volume":"86","author":"Colao","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B29","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1210\/jc.2004-2466","article-title":"A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly","volume":"90","author":"Melmed","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11102-009-0169-z","article-title":"Effects of lanreotide SR and Autogel on tumor mass in patients with acromegaly: a systematic review","volume":"13","author":"Mazziotti","year":"2010","journal-title":"Pituitary"},{"key":"key\n\t\t\t\t2019041113383503600_B31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.7326\/0003-4819-117-9-719","article-title":"Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion","volume":"117","author":"Lim","year":"1992","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113383503600_B32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7326\/0003-4819-113-12-921","article-title":"Cardiovascular effects of the somatostatin analog octreotide in acromegaly","volume":"113","author":"Chanson","year":"1990","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113383503600_B33","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1210\/jc.2002-021746","article-title":"The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly","volume":"88","author":"Smith","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B34","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1210\/jc.2010-2225","article-title":"Changes in arterial stiffness but not carotid intimal thickness in acromegaly","volume":"96","author":"Paisley","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2265.2001.01358.x","article-title":"Effect of Sandostatin LAR on sleep apnoea in acromegaly: correlation with computerized tomographic cephalometry and hormonal activity","volume":"55","author":"Ip","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000095535","article-title":"Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs","volume":"83","author":"Tolis","year":"2006","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t2019041113383503600_B37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1530\/eje.0.1510309","article-title":"Effects of octreotide on sleep apnoea and tongue volume (magnetic resonance imaging) in patients with acromegaly","volume":"151","author":"Herrmann","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2265.2011.03982.x","article-title":"Six-month preoperative octreotide treatment in unselected, de novo patients with acromegaly: effect on biochemistry, tumour volume, and postoperative cure","volume":"74","author":"Carlsen","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B39","doi-asserted-by":"crossref","first-page":"e36411","DOI":"10.1371\/journal.pone.0036411","article-title":"Meta-analysis on the effects of octreotide on tumor mass in acromegaly","volume":"7","author":"Giustina","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113383503600_B40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1210\/jc.2009-1912","article-title":"Endocrine aspects of obstructive sleep apnea","volume":"95","author":"Attal","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B41","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1046\/j.1365-2265.1996.00852.x","article-title":"Sleep apnoea in treated acromegaly: relative frequency and predisposing factors","volume":"45","author":"Rosenow","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B42","doi-asserted-by":"crossref","first-page":"478","DOI":"10.7326\/0003-4819-121-7-199410010-00002","article-title":"Effect of octreotide, a somatostatin analog, on sleep apnea in patients with acromegaly","volume":"121","author":"Grunstein","year":"1994","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113383503600_B43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1530\/EJE-08-0442","article-title":"Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease","volume":"159","author":"Davi","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B44","doi-asserted-by":"crossref","first-page":"527","DOI":"10.7326\/0003-4819-115-7-527","article-title":"Sleep apnea in acromegaly","volume":"115","author":"Grunstein","year":"1991","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113383503600_B45","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1136\/thx.50.9.972","article-title":"Validation of British Thoracic Society guidelines for the diagnosis of the sleep apnoea\/hypopnoea syndrome: can polysomnography be avoided?","volume":"50","author":"Ryan","year":"1995","journal-title":"Thorax"},{"key":"key\n\t\t\t\t2019041113383503600_B46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1010-5182(02)00182-8","article-title":"Cephalometric assessment of cranial abnormalities in patients with acromegaly","volume":"31","author":"Dost\u00e1lov\u00e1","year":"2003","journal-title":"J Craniomaxillofac Surg"},{"key":"key\n\t\t\t\t2019041113383503600_B47","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1001\/jama.284.23.3015","article-title":"Longitudinal study of moderate weight change and sleep-disordered breathing","volume":"284","author":"Peppard","year":"2000","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113383503600_B48","first-page":"381","article-title":"Body composition and energy expenditure in acromegaly","volume":"78","author":"O'Sullivan","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2265.2001.01280.x","article-title":"Bone metabolism and body composition in Japanese patients with active acromegaly","volume":"55","author":"Kaji","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2265.1994.tb02552.x","article-title":"Body composition in active acromegaly during treatment with octreotide: a double-blind, placebo-controlled cross-over study","volume":"41","author":"Hansen","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383503600_B51","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1530\/EJE-08-0449","article-title":"Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females","volume":"159","author":"Sucunza","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B52","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1530\/EJE-11-0408","article-title":"Determinants of cardiac disease in newly diagnosed patients with acromegaly: results of a 10 year survey study","volume":"165","author":"Colao","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B53","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1530\/eje.0.151s093","article-title":"The heart: an end-organ of GH action","volume":"151","author":"Colao","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B54","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1210\/edrv-15-5-555","article-title":"Growth hormone and the heart","volume":"15","author":"Sacc\u00e0","year":"1994","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113383503600_B55","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1210\/jcem.87.7.8643","article-title":"Early vascular alterations in acromegaly","volume":"87","author":"Brevetti","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383503600_B56","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041113383503600_B57","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1507\/endocrj.K07E-125","article-title":"Improvement of endothelial dysfunction in acromegaly after transsphenoidal surgery","volume":"55","author":"Sakai","year":"2008","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t2019041113383503600_B58","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1570161053586958","article-title":"Somatostatin: a hormone for the heart?","volume":"3","author":"Badway","year":"2005","journal-title":"Curr Vasc Pharmacol"},{"key":"key\n\t\t\t\t2019041113383503600_B59","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1677\/joe.1.06082","article-title":"Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts","volume":"187","author":"Smith","year":"2005","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383503600_B60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2265.2003.01689.x","article-title":"Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide","volume":"58","author":"Colao","year":"2003","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/3\/1040\/10420603\/jcem1040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T08:23:48Z","timestamp":1562660628000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/3\/1040\/2536648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-3072","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.723730401.793511695","asserted-by":"object"}]},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}