{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:12:32Z","timestamp":1790730752312,"version":"4.1.0"},"reference-count":24,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"DOI":"10.1210\/jc.2012-3273","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T05:42:51Z","timestamp":1361943771000},"page":"1403-1408","source":"Crossref","is-referenced-by-count":81,"title":["Congenital Hypothyroidism due to Defects of Thyroid Development and Mild Increase of TSH at Screening: Data From the Italian National Registry of Infants With Congenital Hypothyroidism"],"prefix":"10.1210","volume":"98","author":[{"given":"Antonella","family":"Olivieri","sequence":"first","affiliation":[{"name":"Metabolism and Endocrinology Unit (A.O., C.F.), 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Regional Newborn Screening Laboratory of Lombardia Region (C.C.), Children's Hospital V. Buzzi, 20154 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (G.W., M.C.V.), Vita-Salute S. Raffaele University, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Vigone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (G.W., M.C.V.), Vita-Salute S. Raffaele University, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fazzini","sequence":"additional","affiliation":[{"name":"Metabolism and Endocrinology Unit (A.O., C.F.), 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Medda","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neurosciences, and National Centre for Epidemiology Surveillance and Health Promotion (E.M.), Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Italian Study Group for Congenital Hypothyroidism","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113280688800_B1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1172-5-17","article-title":"Congenital hypothyroidism","volume":"5","author":"Rastogy","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"key\n\t\t\t\t2019041113280688800_B2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrendo.2011.160","article-title":"Detection and treatment of congenital hypothyroidism","volume":"8","author":"Gr\u00fcters","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t2019041113280688800_B3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2265.2009.03568.x","article-title":"A 7-year experience with low blood cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH)","volume":"71","author":"Corbetta","year":"2009","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t2019041113280688800_B4","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1210\/jc.2010-0057","article-title":"Screening for congenital hypothyroidism: the significance of threshold limit in false-negative results","volume":"95","author":"Mengreli","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B5","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1210\/jc.2011-1073","article-title":"Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Quebec","volume":"96","author":"Deladoey","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B6","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jc.2011-1850","article-title":"Increasing incidence of congenital hypothyroidism: some answers, more questions","volume":"96","author":"LaFranchi","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/adc.2010.199273","article-title":"Congenital hypothyroidism: managing the hinterland between fact and theory","volume":"96","author":"Cheetham","year":"2011","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113280688800_B8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/adc.2009.174466","article-title":"Treating patients not numbers: the benefit and burden of lowering cut off","volume":"96","author":"Krude","year":"2011","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113280688800_B9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1824-7288-35-2","article-title":"The Italian National Register of infants with congenital hypothyroidism: twenty years of surveillance and study of congenital hypothyroidism","volume":"35","author":"Olivieri","year":"2009","journal-title":"Ital J Pediatr"},{"key":"key\n\t\t\t\t2019041113280688800_B10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10545-011-9286-8","article-title":"Newborn screening for congenital hypothyroidism in very-low-birth-weight babies: the need for a second test","volume":"34","author":"Bijarnia","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"key\n\t\t\t\t2019041113280688800_B11","first-page":"317","article-title":"Thyroid function and dysfunction in premature infants","volume":"4","author":"Fisher","year":"2007","journal-title":"Pediatr Endocrinol Rev"},{"key":"key\n\t\t\t\t2019041113280688800_B12","first-page":"973","article-title":"Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), freeT3, freeT4, thyroxine binding globuline (TBG) and thyrotropin (TSH)","volume":"39","author":"Elminger","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t2019041113280688800_B13","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1210\/jc.2004-0869","article-title":"Developmental trends in cord and postpartum serum thyroid hormones in preterm infants","volume":"89","author":"Williams","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B14","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1542\/peds.2006-0915","article-title":"Update of newborn screening and therapy for congenital hypothyroidism","volume":"117","author":"Rose","year":"2006","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2019041113280688800_B15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1365-2265.2005.02239.x","article-title":"Proportion of various types of thyroid disorders among newborns with congenital hypothyroidism and normally located gland: regional cohort study","volume":"62","author":"Gaudino","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113280688800_B16","first-page":"557","article-title":"A population-based study on the frequency of additional congenital malformations in infants with congenital hypothyroidism: data from the Italian Registry for Congenital Hypothyroidism (1991\u20131998)","volume":"87","author":"Olivieri","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B17","first-page":"227","article-title":"Thyroid dysfunction in pregnancy","volume":"5","author":"El Baba","year":"2012","journal-title":"Int J Gen Med"},{"key":"key\n\t\t\t\t2019041113280688800_B18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/eje.1.02048","article-title":"Risk factors for congenital hypothyroidism: results of a population case-control study (1997\u20132003)","volume":"153","author":"Medda","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113280688800_B19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/jc.2006-1219","article-title":"Prematurity may be a risk factor for thyroid dysfunction in childhood","volume":"92","author":"Radetti","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B20","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1515\/JPEM.2005.18.S1.1257","article-title":"Neonatal iodine deficiency: clinical aspects","volume":"18","author":"Ares","year":"2005","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.beem.2009.09.003","article-title":"Iodine in enteral and parenteral nutrition","volume":"24","author":"Zimmermann","year":"2010","journal-title":"Best Pract res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B22","doi-asserted-by":"crossref","first-page":"E632","DOI":"10.1210\/jc.2011-3369","article-title":"Loww iodine content in the diets of hospitalized preterm infants","volume":"97","author":"Belfort","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113280688800_B23","unstructured":"National Newborn Screening and Genetics Resource Center (NNSGRC). 2009National Newborn Screening Information System 2009. Available at http:\/\/genes-r-us.uthscsa.edu."},{"key":"key\n\t\t\t\t2019041113280688800_B24","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1007\/s10545-010-9062-1","article-title":"Newborn screening strategies for congenital hypothyroidism: an update","volume":"33","author":"LaFranchi","year":"2010","journal-title":"J Inherit Metab Dis"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/4\/1403\/9045454\/jcem1403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:41:52Z","timestamp":1562719312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/4\/1403\/2536750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-3273","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}