{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:26:31Z","timestamp":1790400391213,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"DOI":"10.1210\/jc.2012-3698","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T02:01:12Z","timestamp":1360116072000},"page":"1254-1263","source":"Crossref","is-referenced-by-count":103,"title":["Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)"],"prefix":"10.1210","volume":"98","author":[{"given":"Susana","family":"Borruel","sequence":"first","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"},{"name":"Department of Radiology (S.B.), Hospital Universitario 12 de Octubre, E-28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fern\u00e1ndez-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Alpa\u00f1\u00e9s","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"\u00c1lvarez-Blasco","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Luque-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity, and Human Reproduction Research Group (S.B., E.F.-D., M.A., D.M., F.A.-B., M.L.-R., H.F.E.-M.), Universidad de Alcal\u00e1 and Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113231541900_B1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.beem.2007.04.007","article-title":"Sexual dimorphism of body composition","volume":"21","author":"Wells","year":"2007","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archinte.165.7.777","article-title":"Obesity, regional body fat distribution, and the metabolic syndrome in older men and women","volume":"165","author":"Goodpaster","year":"2005","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113231541900_B3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tem.2007.07.003","article-title":"Abdominal adiposity and the polycystic ovary syndrome","volume":"18","author":"Escobar-Morreale","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1210\/jc.2006-1665","article-title":"Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome","volume":"92","author":"Corton","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/dem380","article-title":"Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry","volume":"23","author":"Corton","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113231541900_B6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000182732","article-title":"Insulin and androgen relationships with abdominal body fat distribution in women with and without hyperandrogenism","volume":"39","author":"Pasquali","year":"1993","journal-title":"Horm Res"},{"key":"key\n\t\t\t\t2019041113231541900_B7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1210\/jc.2007-2117","article-title":"Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome","volume":"93","author":"Barber","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3904\/kjim.2009.24.4.350","article-title":"Serum C-reactive protein levels in normal-weight polycystic ovary syndrome","volume":"24","author":"Oh","year":"2009","journal-title":"Korean J Intern Med"},{"key":"key\n\t\t\t\t2019041113231541900_B9","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/humrep\/der070","article-title":"Comparison of MRI-assessed body fat content between lean women with polycystic ovary syndrome (PCOS) and matched controls: less visceral fat with PCOS","volume":"26","author":"Dolfing","year":"2011","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113231541900_B10","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.1210\/jc.2010-0828","article-title":"Effects of exercise on insulin resistance and body composition in overweight and obese women with and without polycystic ovary syndrome","volume":"96","author":"Hutchison","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1600-0412.2011.01124.x","article-title":"Ultrasonographic extended-view technique for evaluation of abdominal fat distribution in lean women with polycystic ovary syndrome","volume":"90","author":"Battaglia","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113231541900_B12","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1210\/jc.2012-1382","article-title":"Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis, compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance","volume":"97","author":"Jones","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/humrep\/dem356","article-title":"Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome","volume":"23","author":"Cascella","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113231541900_B14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/09513590.2011.589929","article-title":"Evaluation of body fat distribution in PCOS and its association with carotid atherosclerosis and insulin resistance","volume":"28","author":"Karabulut","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t2019041113231541900_B15","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1210\/jc.2010-1290","article-title":"Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance","volume":"96","author":"Manneras-Holm","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-277X.2010.01130.x","article-title":"Upper trunk fat assessment and its relationship with metabolic and biochemical variables and body fat in polycystic ovary syndrome","volume":"24","author":"Penaforte","year":"2011","journal-title":"J Hum Nutr Diet"},{"key":"key\n\t\t\t\t2019041113231541900_B17","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki","year":"1992"},{"key":"key\n\t\t\t\t2019041113231541900_B18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113231541900_B19","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1210\/jc.2007-2053","article-title":"A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs","volume":"93","author":"Escobar-Morreale","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B21","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0015-0282(00)00718-4","article-title":"Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity","volume":"74","author":"Escobar-Morreale","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113231541900_B22","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113231541900_B23","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO Consultation","author":"World Health Organization","year":"2000"},{"key":"key\n\t\t\t\t2019041113231541900_B24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/sj.ijo.0802398","article-title":"Sonographic measurement of mesenteric fat thickness is a good correlate with cardiovascular risk factors: comparison with subcutaneous and preperitoneal fat thickness, magnetic resonance imaging and anthropometric indexes","volume":"27","author":"Liu","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key\n\t\t\t\t2019041113231541900_B25","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1136\/hrt.2007.118471","article-title":"Relationship of epicardial adipose tissue by echocardiography to coronary artery disease","volume":"94","author":"Ahn","year":"2008","journal-title":"Heart"},{"key":"key\n\t\t\t\t2019041113231541900_B26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/gast.2002.35354","article-title":"The utility of radiological imaging in nonalcoholic fatty liver disease","volume":"123","author":"Saadeh","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2019041113231541900_B27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2012.07.001","article-title":"A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity","volume":"363","author":"Insenser","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113231541900_B28","article-title":"Evidence for masculinization of adipokine gene expression in visceral and subcutaneous adipose tissue of obese women with polycystic ovary syndrome (PCOS) [published online ahead of print January 21, 2013]","author":"Mart\u00ednez-Garc\u00eda","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113231541900_B30","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1210\/jc.2007-1549","article-title":"Glucose intolerance in polycystic ovary syndrome\u2014a position statement of the Androgen Excess Society","volume":"92","author":"Salley","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B31","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"Wild","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113231541900_B32","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1373\/clinchem.2011.176396","article-title":"Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS","volume":"58","author":"Escobar-Morreale","year":"2012","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113231541900_B33","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2214\/AJR.07.2366","article-title":"Sonographic assessment of regional adiposity","volume":"189","author":"Vlachos","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"key\n\t\t\t\t2019041113231541900_B34","first-page":"771","article-title":"Anthropometric or ultrasonic measurements in assessment of visceral fat? A comparative study","volume":"18","author":"Tornaghi","year":"1994","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key\n\t\t\t\t2019041113231541900_B35","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1381\/096089202321019620","article-title":"Ultrasound measurement of visceral and subcutaneous fat in morbidly obese patients before and after laparoscopic adjustable gastric banding: comparison with computerized tomography and with anthropometric measurements","volume":"12","author":"Pontiroli","year":"2002","journal-title":"Obes Surg"},{"key":"key\n\t\t\t\t2019041113231541900_B36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2114\/ahs.14.133","article-title":"Use of B-mode ultrasound for visceral fat mass evaluation: comparisons with magnetic resonance imaging","volume":"14","author":"Abe","year":"1995","journal-title":"Appl Human Sci"},{"key":"key\n\t\t\t\t2019041113231541900_B37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1210\/jc.2010-1608","article-title":"Sonographic measurement of mesenteric fat predicts presence of fatty liver among subjects with polycystic ovary syndrome","volume":"96","author":"Ma","year":"2011","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/3\/1254\/10420952\/jcem1254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T05:30:38Z","timestamp":1562650238000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/3\/1254\/2536818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-3698","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}