{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:56Z","timestamp":1792226816598,"version":"4.4.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"\n Context:<\/jats:title>\n We recently found that patients with X-linked hypophosphatemic rickets (XLH) have a muscle function deficit in the lower extremities. As muscle force and bone mass are usually closely related, we hypothesized that patients with XLH could also have a bone mass deficit in the lower extremities.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The study objective was to assess the muscle-bone relationship in the lower extremities of patients with XLH.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n The study was carried out in the outpatients department of a pediatric orthopedic hospital.<\/jats:p>\n <\/jats:sec>\n \n Patients and Other Participants:<\/jats:title>\n Thirty individuals with XLH (6 to 60 y; 9 male patients) and 30 age- and gender-matched controls participated.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures:<\/jats:title>\n Calf muscle size and density as well as tibia bone mass and geometry were assessed by peripheral quantitative computed tomography. Muscle function was evaluated as peak force in the multiple 2-legged hopping test.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Muscle force was significantly lower in XLH patients than in controls but muscle cross-sectional area did not differ (after adjustment for tibia length). External bone size, expressed as total bone cross-sectional area, was higher in the XLH group than in controls. The XLH cohort also had statistically significantly higher bone mineral content.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Patients with XLH have increased bone mass and size at the distal tibia despite muscle function deficits.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/jc.2012-4146","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T00:19:21Z","timestamp":1363997961000},"page":"E990-E995","source":"Crossref","is-referenced-by-count":49,"title":["The Muscle-Bone Relationship in X-Linked Hypophosphatemic Rickets"],"prefix":"10.1210","volume":"98","author":[{"given":"Louis-Nicolas","family":"Veilleux","sequence":"first","affiliation":[{"name":"Shriners Hospital for Children and Department of Pediatrics, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira S.","family":"Cheung","sequence":"first","affiliation":[{"name":"Shriners Hospital for Children and Department 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