{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:24:24Z","timestamp":1782933864426,"version":"3.54.5"},"reference-count":17,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"DOI":"10.1210\/jc.2012-4174","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T15:29:44Z","timestamp":1367422184000},"page":"2902-2907","source":"Crossref","is-referenced-by-count":18,"title":["Circulating Serotonin and Bone Density, Structure, and Turnover in Carcinoid Syndrome"],"prefix":"10.1210","volume":"98","author":[{"given":"Jennifer S.","family":"Walsh","sequence":"first","affiliation":[{"name":"Academic Unit of Bone Metabolism (J.S.W., M.D., R.E.), University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Newell-Price","sequence":"additional","affiliation":[{"name":"Department of Human Metabolism (J.D.N.-P.), University of Sheffield, Sheffield S10 2JF, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"DeBono","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism (J.S.W., M.D., R.E.), University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Adaway","sequence":"additional","affiliation":[{"name":"School of Medicine (J.A., B.K.), University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Keevil","sequence":"additional","affiliation":[{"name":"School of Medicine (J.A., B.K.), University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism (J.S.W., M.D., R.E.), University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113374454400_B1","first-page":"1513","article-title":"High bone density due to a mutation in LDL-receptor-related protein 5","volume":"346","author":"Boyden","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113374454400_B2","first-page":"513","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113374454400_B3","first-page":"825","article-title":"Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum","volume":"135","author":"Yadav","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113374454400_B4","first-page":"2002","article-title":"Efficacy of serotonin inhibition in mouse models of bone loss","volume":"26","author":"Inose","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113374454400_B5","first-page":"308","article-title":"Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis","volume":"16","author":"Yadav","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113374454400_B6","first-page":"684","article-title":"Lrp5 functions in bone to regulate bone mass","volume":"17","author":"Cui","year":"2011","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113374454400_B7","first-page":"477","article-title":"Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake","volume":"29","author":"Bliziotes","year":"2001","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113374454400_B8","first-page":"1721","article-title":"Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5 J","volume":"26","author":"Frost","year":"2011","journal-title":"Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113374454400_B9","first-page":"673","article-title":"Patients with high-bone-mass phenotype owing to Lrp5\u2013T253I mutation have low plasma levels of serotonin","volume":"25","author":"Frost","year":"2010","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113374454400_B10","first-page":"61","article-title":"Gastroenteropancreatic neuroendocrine tumours","volume":"9","author":"Modlin","year":"2008","journal-title":"Lancet Oncol"},{"key":"key\n\t\t\t\t2019041113374454400_B11","first-page":"1260","article-title":"5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients","volume":"50","author":"van Dijk","year":"2012","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113374454400_B12","first-page":"695","article-title":"Measurement of plasma 5-hydroxyindole acetic acid by liquid chromatography tandem mass spectrometry\u2014comparison with HPLC methodology","volume":"878","author":"Miller","year":"2010","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key\n\t\t\t\t2019041113374454400_B13","first-page":"1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113374454400_B14","first-page":"415","article-title":"Relation of serum serotonin levels to bone density and structural parameters in women","volume":"25","author":"Modder","year":"2010","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113374454400_B15","first-page":"3490","article-title":"FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin","volume":"122","author":"Kode","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113374454400_B16","first-page":"2567","article-title":"Decreased osteoclastogenesis in serotonin-deficient mice","volume":"109","author":"Chabbi-Achengli","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113374454400_B17","first-page":"188","article-title":"Serum levels of bone Gla protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in acromegaly: effects of long-term octreotide treatment","volume":"52","author":"Terzolo","year":"1993","journal-title":"Calcif Tissue Int"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/7\/2902\/9048165\/jcem2902.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T03:40:52Z","timestamp":1555040452000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/7\/2902\/2537100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,1]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2012-4174","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,1]]}}}