{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:58:31Z","timestamp":1789401511001,"version":"build-2803163510"},"reference-count":44,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"DOI":"10.1210\/jc.2013-1328","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T23:21:34Z","timestamp":1365808894000},"page":"1838-1844","source":"Crossref","is-referenced-by-count":46,"title":["The Use of Aromatase Inhibitors for Ovulation Induction and Superovulation"],"prefix":"10.1210","volume":"98","author":[{"given":"Mary Ellen","family":"Pavone","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Biology (M.E.P., S.E.B.), Chicago, Illinois 60611"},{"name":"Division of Reproductive Endocrinology and Infertility (M.E.P., S.E.B.), Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar E.","family":"Bulun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Biology (M.E.P., S.E.B.), Chicago, Illinois 60611"},{"name":"Division of Reproductive Endocrinology and Infertility (M.E.P., S.E.B.), Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113485751300_B1","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0002-9378(98)70238-8","article-title":"Polycystic ovary syndrome: symptomatology, pathophysiology, and epidemiology","volume":"179","author":"Guzick","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113485751300_B2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0306-3356(21)00138-2","article-title":"Ovulatory disorders in women with polycystic ovary syndrome","volume":"12","author":"Franks","year":"1985","journal-title":"Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113485751300_B3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00006254-196512000-00001","article-title":"Induction of ovulation with clomiphene citrate (clomid)","volume":"20","author":"Kistner","year":"1965","journal-title":"Obstet Gynecol Surv"},{"key":"key\n\t\t\t\t2019041113485751300_B4","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.fertnstert.2007.05.010","article-title":"Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial","volume":"89","author":"Badawy","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/00016340601090337","article-title":"N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial","volume":"86","author":"Badawy","year":"2007","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113485751300_B6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.fertnstert.2006.02.097","article-title":"Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial","volume":"86","author":"Badawy","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B7","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.2165\/00003495-200666170-00001","article-title":"Potential of aromatase inhibitors for ovulation and superovulation induction in infertile women","volume":"66","author":"Mitwally","year":"2006","journal-title":"Drugs"},{"key":"key\n\t\t\t\t2019041113485751300_B8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2265.2011.04006.x","article-title":"Aromatase inhibitors for ovulation induction and ovarian stimulation","volume":"74","author":"Lee","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113485751300_B9","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.fertnstert.2012.09.022","article-title":"Ovarian stimulation and fertility preservation with the use of aromatase inhibitors in women with breast cancer","volume":"98","author":"Reddy","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B10","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.fertnstert.2012.09.042","article-title":"The use of aromatase inhibitors in in vitro fertilization","volume":"98","author":"Garcia-Velasco","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/humupd\/dmi034","article-title":"Aromatase and other steroidogenic genes in endometriosis: translational aspects","volume":"12","author":"Attar","year":"2006","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t2019041113485751300_B12","first-page":"75","article-title":"Aromatase gene expression in adipose tissue: relationship to breast cancer","volume":"39","author":"Simpson","year":"1994","journal-title":"Int J Fertil Menopausal Stud"},{"key":"key\n\t\t\t\t2019041113485751300_B13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1210\/jcem-36-2-207","article-title":"Source of estrogen production in postmenopausal women","volume":"36","author":"Grodin","year":"1973","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113485751300_B14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0960-0760(94)90274-7","article-title":"Aromatase gene expression in adipose tissue: relationship to breast cancer","volume":"49","author":"Bulun","year":"1994","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041113485751300_B15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113485751300_B16","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.fertnstert.2012.08.053","article-title":"Aromatase inhibitors for the treatment of endometriosis","volume":"98","author":"Pavone","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1477-7827-9-90","article-title":"Aromatase inhibitors in post-menopausal endometriosis","volume":"9","author":"Polyzos","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t2019041113485751300_B18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1023\/A:1008388823113","article-title":"Tumor response and estrogen suppression in breast cancer patients treated with aromatase inhibitors","volume":"11","author":"Bajetta","year":"2000","journal-title":"Ann Oncol"},{"key":"key\n\t\t\t\t2019041113485751300_B19","first-page":"2089","article-title":"In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients","volume":"4","author":"Geisler","year":"1998","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019041113485751300_B20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/bjc.1996.531","article-title":"Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer","volume":"74","author":"Geisler","year":"1996","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t2019041113485751300_B21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0960-0760(95)00045-2","article-title":"ARIMIDEX: a new oral, once-a-day aromatase inhibitor","volume":"53","author":"Plourde","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041113485751300_B22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/edrv-11-2-221","article-title":"Endocrine treatment of breast cancer in women","volume":"11","author":"Santen","year":"1990","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113485751300_B23","first-page":"1511","article-title":"In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer","volume":"1","author":"Dowsett","year":"1995","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019041113485751300_B24","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2165\/00003495-200969080-00001","article-title":"Pharmacological treatment of endometriosis: experience with aromatase inhibitors","volume":"69","author":"Ferrero","year":"2009","journal-title":"Drugs"},{"key":"key\n\t\t\t\t2019041113485751300_B25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/GRF.0b013e3182353d0f","article-title":"Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome","volume":"54","author":"Casper","year":"2011","journal-title":"Clin Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113485751300_B26","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.fertnstert.2012.10.008","article-title":"A historical perspective of aromatase inhibitors for ovulation induction","volume":"98","author":"Casper","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0015-0282(00)01705-2","article-title":"Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate","volume":"75","author":"Mitwally","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B28","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.fertnstert.2005.09.045","article-title":"Letrozole vs. clomiphene citrate in patients with ovulatory infertility","volume":"85","author":"Bayar","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/147323000603400109","article-title":"Comparison of letrozole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation","volume":"34","author":"Atay","year":"2006","journal-title":"J Int Med Res"},{"key":"key\n\t\t\t\t2019041113485751300_B30","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.fertnstert.2010.06.008","article-title":"Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial","volume":"94","author":"Kamath","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B31","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.fertnstert.2009.07.985","article-title":"Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial","volume":"94","author":"Abu Hashim","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00404-010-1566-2","article-title":"Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial","volume":"282","author":"Abu Hashim","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t2019041113485751300_B33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.fertnstert.2007.08.044","article-title":"Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome","volume":"92","author":"Begum","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.fertnstert.2007.10.016","article-title":"Aromatase inhibitors for infertility in polycystic ovary syndrome. The beginning or the end of a new era?","volume":"89","author":"Polyzos","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/00016340802638199","article-title":"Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility","volume":"88","author":"Badawy","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113485751300_B36","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.fertnstert.2008.06.013","article-title":"Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial","volume":"92","author":"Badawy","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00404-008-0888-9","article-title":"Endometrial and follicular development following letrozole intervention in unexplained infertile patients failed to get pregnant with clomiphene citrate","volume":"280","author":"Samani","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t2019041113485751300_B38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1477-7827-9-84","article-title":"Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial","volume":"9","author":"Fouda","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t2019041113485751300_B39","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1600-0412.2011.01346.x","article-title":"Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis","volume":"91","author":"Abu Hashim","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113485751300_B40","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.fertnstert.2005.07.230","article-title":"The outcome of 150 babies following the treatment with letrozole or letrozole with gonadotropins","volume":"84","author":"Biljan","year":"2005","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B41","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.fertnstert.2006.03.014","article-title":"Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate","volume":"85","author":"Tulandi","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113485751300_B42","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/jc.2005-1923","article-title":"Review: aromatase inhibitors for ovulation induction","volume":"91","author":"Casper","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113485751300_B43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ajog.2004.08.013","article-title":"Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation","volume":"192","author":"Mitwally","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113485751300_B44","doi-asserted-by":"crossref","first-page":"1199.e9","DOI":"10.1016\/j.fertnstert.2007.08.065","article-title":"Triplet pregnancy after ovulation induction with an aromatase inhibitor","volume":"90","author":"Dicken","year":"2008","journal-title":"Fertil Steril"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/5\/1838\/9045221\/jcem1838.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T12:43:28Z","timestamp":1644756208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/5\/1838\/2536792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-1328","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,1]]}}}