{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:50:28Z","timestamp":1757703028853},"reference-count":38,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"DOI":"10.1210\/jc.2013-1341","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T01:44:43Z","timestamp":1369446283000},"page":"3049-3057","source":"Crossref","is-referenced-by-count":8,"title":["Sex Hormone Binding Globulin and Sex Steroids Among Premenopausal Women in the Diabetes Prevention Program"],"prefix":"10.1210","volume":"98","author":[{"given":"Catherine","family":"Kim","sequence":"first","affiliation":[{"name":"University of Michigan (C.K., S.K., B.N.), Ann Arbor, Michigan 48109-2800;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Pi-Sunyer","sequence":"additional","affiliation":[{"name":"Columbia University (X.P.-S.), New York, New York 10025;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Barrett-Connor","sequence":"additional","affiliation":[{"name":"University of California, San Diego (E.B.-C.), La Jolla, California 92903;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frankie B.","family":"Stentz","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center (F.B.S., M.B.M., A.E.K.), Memphis, Tennessee 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Murphy","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center (F.B.S., M.B.M., A.E.K.), Memphis, Tennessee 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengchun","family":"Kong","sequence":"additional","affiliation":[{"name":"University of Michigan (C.K., S.K., B.N.), Ann Arbor, Michigan 48109-2800;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Nan","sequence":"additional","affiliation":[{"name":"University of Michigan (C.K., S.K., B.N.), Ann Arbor, Michigan 48109-2800;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas E.","family":"Kitabchi","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center (F.B.S., M.B.M., A.E.K.), Memphis, Tennessee 38163"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Diabetes Prevention Program Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113342254900_B1","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/jnci\/djj376","article-title":"Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women","volume":"98","author":"Eliassen","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113342254900_B2","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/jama.295.11.1288","article-title":"Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"295","author":"Ding","year":"2006","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113342254900_B3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/bjc.2011.254","article-title":"Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies","volume":"105","author":"Endogenous Hormones and Breast Cancer Collaborative Group","year":"2011","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t2019041113342254900_B4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113342254900_B5","first-page":"CD007506","article-title":"Lifestyle changes in women with polycystic ovary syndrome","author":"Moran","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t2019041113342254900_B6","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/humrep\/deq172","article-title":"Estrogen and progesterone exposure is reduced in response to energy deficiency in women aged 25\u201340 years","volume":"25","author":"Williams","year":"2010","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113342254900_B7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113342254900_B8","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2008-0115","article-title":"Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome","volume":"93","author":"Elkind-Hirsch","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B9","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2005-2250","article-title":"Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study","volume":"91","author":"Gambineri","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B10","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1210\/jcem.85.8.6738","article-title":"Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome","volume":"85","author":"Pasquali","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B11","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1210\/jc.2011-1314","article-title":"Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women","volume":"96","author":"Marsh","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B12","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1210\/jc.2002-020777","article-title":"Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status","volume":"88","author":"Randolph","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B13","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1210\/jc.2003-031183","article-title":"Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age","volume":"89","author":"Randolph","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"journal-title":"Obesity (Silver Spring)","article-title":"Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women","author":"Wildman","key":"key\n\t\t\t\t2019041113342254900_B14"},{"key":"key\n\t\t\t\t2019041113342254900_B15","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.2337\/diabetes.54.8.2404","article-title":"Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the Diabetes Prevention Program: effects of lifestyle intervention and metformin","volume":"54","author":"Kitabchi","year":"2005","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113342254900_B16","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.2337\/diabetes.53.8.2079","article-title":"Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises","volume":"53","author":"Stentz","year":"2004","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113342254900_B17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/oby.2011.383","article-title":"Postmenopausal sex hormones in relation to body fat distribution","volume":"20","author":"Liedtke","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"key\n\t\t\t\t2019041113342254900_B18","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1200\/JCO.2009.24.9557","article-title":"Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women","volume":"28","author":"Friedenreich","year":"2010","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t2019041113342254900_B19","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1158\/0008-5472.CAN-03-3393","article-title":"Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial","volume":"64","author":"McTiernan","year":"2004","journal-title":"Canc Res"},{"key":"key\n\t\t\t\t2019041113342254900_B20","first-page":"25","article-title":"Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial","volume":"10","author":"Berrino","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019041113342254900_B21","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1210\/jc.2012-1233","article-title":"Endogenous sex hormone changes in postmenopausal women in the Diabetes Prevention Program","volume":"97","author":"Kim","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B22","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2337\/db10-0179","article-title":"Relationships of circulating sex hormone-binding globulin with metabolic traits in humans","volume":"59","author":"Peter","year":"2010","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113342254900_B23","first-page":"249","article-title":"The effect of endurance training on the relationships between sex hormone binding globulin, high density lipoprotein cholesterol, apoprotein A1c and physical fitness in pre-menopausal women with mild obesity","volume":"18","author":"Kumagai","year":"1994","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key\n\t\t\t\t2019041113342254900_B24","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1210\/en.2008-1289","article-title":"Peroxisome-proliferator receptor \u03b3 represses hepatic sex hormone binding globulin expression","volume":"150","author":"Selva","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113342254900_B25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2337\/diacare.25.1.55","article-title":"Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo Study","volume":"25","author":"Oh","year":"2002","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113342254900_B26","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1210\/jc.2009-0910","article-title":"The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women","volume":"94","author":"Kalyani","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B27","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJMoa0804381","article-title":"Sex hormone-binding globulin and risk of type 2 diabetes in women and men","volume":"361","author":"Ding","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113342254900_B28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/gme.0b013e318185e249","article-title":"Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: Study of Women's Health Across the Nation","volume":"16","author":"Torrens","year":"2009","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113342254900_B29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2337\/dc12-0733","article-title":"Pretreatment, psychological, and behavioral predictors of weight outcomes among lifestyle intervention participants in the Diabetes Prevention Program (DPP)","volume":"36","author":"Delahanty","year":"2013","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113342254900_B30","doi-asserted-by":"crossref","first-page":"E1695","DOI":"10.1210\/jc.2012-1614","article-title":"Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation","volume":"97","author":"Wildman","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B31","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1210\/jc.2008-0772","article-title":"Prevention of diabetes in women with a history of gestational diabetes:; effects of metformin and lifestyle interventions","volume":"93","author":"Ratner","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B32","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1016\/S0021-9258(19)39289-0","article-title":"The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones","volume":"265","author":"Hryjb","year":"1990","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113342254900_B33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/jcem-50-1-113","article-title":"Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease","volume":"50","author":"Burghen","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B34","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.2337\/diacare.22.9.1524","article-title":"Racial differences in the correlation between gonadal androgens and serum insulin levels","volume":"22","author":"Kitabchi","year":"1999","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113342254900_B35","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1158\/1055-9965.EPI-04-0944","article-title":"Racial differences in premenopausal endogenous hormones","volume":"14","author":"Pinheiro","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019041113342254900_B36","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1210\/jc.2006-1191","article-title":"Defining constant versus variable phenotypic features of women with polcystic ovary syndrome using different ethnic groups and populations","volume":"91","author":"Welt","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113342254900_B37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.steroids.2012.10.010","article-title":"Dynamics of serum testosterone during the menstrual cycle evaluated by daily measurements with an ID-LC-MS\/MS method and a 2nd generation automated immunoassay","volume":"78","author":"Bui","year":"2013","journal-title":"Steroids"},{"key":"key\n\t\t\t\t2019041113342254900_B38","first-page":"147","article-title":"The optimal timing of blood collection during menstrual cycle for the assessment of endogenous sex hormones: can interindividual differences in levels over the whole cycle be assessed on a single day","volume":"11","author":"Ahmad","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/7\/3049\/9050021\/jcem3049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T17:12:57Z","timestamp":1645549977000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/7\/3049\/2537257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,1]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-1341","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"type":"print","value":"0021-972X"},{"type":"electronic","value":"1945-7197"}],"subject":[],"published":{"date-parts":[[2013,7,1]]}}}