{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:27:52Z","timestamp":1792808872744,"version":"4.5.0"},"reference-count":53,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is a prevalent disorder that affects women of childbearing age and may be related to obesity and insulin resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The purpose of this systematic review was to appraise the evidence of the impact of lifestyle modification (LSM) interventions on outcomes of women with PCOS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources:<\/jats:title>\n                  <jats:p>Sources included Ovid Medline, OVID Embase, OVID Cochrane Library, Web of Science, Scopus, PsycINFO, and CINAHL (up to January 2011).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Selection:<\/jats:title>\n                  <jats:p>We included randomized controlled trials that enrolled woman of any age with PCOS who received LSM and compared them against women who received no intervention, minimal intervention, or metformin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction:<\/jats:title>\n                  <jats:p>Two authors performed the data extraction independently.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Synthesis:<\/jats:title>\n                  <jats:p>We included 9 trials enrolling 583 women with a high loss to follow-up rate, lack of blinding, and short follow-up. Compared with minimal intervention, LSM significantly reduced fasting blood glucose (weighted mean difference, \u22122.3 mg\/dL; 95% confidence interval, \u22124.5 to \u22120.1, I2 = 72%, P = .04) and fasting blood insulin (weighted mean difference, \u22122.1 \u03bcU\/mL, 95% confidence interval, \u22123.3 to \u22121.0, I2 = 0%, P &amp;lt; .001). Changes in body mass index were associated with changes in fasting blood glucose (P &amp;lt; .001). Metformin was not significantly better than LSM in improving blood glucose or insulin levels. We found no significant effect of LSM on pregnancy rate, and the effect on hirsutism was unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The available evidence suggests that LSM reduces fasting blood glucose and insulin levels in women with PCOS. Metformin has similar effects. Translation of these short-term effects to patient-important outcomes, beyond diabetes prevention, remains uncertain.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2013-2385","type":"journal-article","created":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T02:33:37Z","timestamp":1380854017000},"page":"4655-4663","source":"Crossref","is-referenced-by-count":148,"title":["Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis"],"prefix":"10.1210","volume":"98","author":[{"given":"Juan Pablo","family":"Domecq","sequence":"first","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"},{"name":"Unidad de Conocimiento y Evidencia (J.P.D., G.P. V.M.M.), Lima, Peru 32"},{"name":"Department of Internal Medicine (J.P.D.), Henry Ford Hospital, Detroit, Michigan 48202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Prutsky","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"},{"name":"Unidad de Conocimiento y Evidencia (J.P.D., G.P. V.M.M.), Lima, Peru 32"},{"name":"Department of Pediatrics (G.P.), Children's Hospital of Michigan, Wayne State University School of Medicine\/Detroit Medical Center, Detroit, Michigan 48201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Mullan","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"},{"name":"University of Minnesota Medical School (R.J.M.), Minneapolis, Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hazem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.H.), University of North Dakota, Fargo, North Dakota 58102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Sundaresh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (V.S.), Louisiana State University Health Sciences Center, Shreveport, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed B.","family":"Elamin","sequence":"additional","affiliation":[{"name":"Department of Medicine (M.B.E.), Texas Tech University Health Science Center at Amarillo, Amarillo, Texas 79106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Phung","sequence":"additional","affiliation":[{"name":"Pharmacy Practice (O.J.P.), Western University of Health Sciences, Pomona, California 91766"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wang","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"},{"name":"Division of General Internal Medicine (A.W.), Mayo Clinic, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hoeger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (K.H.), Division of Reproductive Endocrinology, University of Rochester Medical Center, Rochester, New York 14627"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (R.P.), Department of Clinical Medicine, Sant'Orsola-Malpighi Hospital, University Alma Mater Studiorum of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Erwin","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Bodde","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Montori","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905"},{"name":"Division of Endocrinology, Diabetes, Metabolism, Nutrition (V.M.M.), Rochester, Minnesota 55905"},{"name":"Unidad de Conocimiento y Evidencia (J.P.D., G.P. 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