{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:38:13Z","timestamp":1793284693220,"version":"4.5.0"},"reference-count":51,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"DOI":"10.1210\/jc.2013-2531","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T23:58:20Z","timestamp":1379030300000},"page":"E1757-E1767","source":"Crossref","is-referenced-by-count":158,"title":["Paracetamol, Aspirin, and Indomethacin Induce Endocrine Disturbances in the Human Fetal Testis Capable of Interfering With Testicular Descent"],"prefix":"10.1210","volume":"98","author":[{"given":"S\u00e9verine","family":"Mazaud-Guittot","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe Nicolas","family":"Nicolaz","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christ\u00e8le","family":"Desdoits-Lethimonier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Coiffec","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millissia Ben","family":"Maamar","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Canc\u00e9rologie de Montpellier (P.B.), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U896, Centre R\u00e9gional de Lutte contre le Cancer Val d'Aurelle Paul Lamarque, Universit\u00e9 Montpellier 1, 34298 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"},{"name":"Department of Biomedical Sciences (D.M.K.), Faculty of Health Sciences, University of Copenhagen, DK1165 Copenhagen K, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Chevrier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lavou\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Rennes (P.P., V.L.), Service Gynecologie et Obstetrique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Poulain","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Rennes (P.P., V.L.), Service Gynecologie et Obstetrique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dejucq-Rainsford","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"J\u00e9gou","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (S.M.-G., C.N.N., C.D.-L., I.C., M.B.M., D.M.K., C.C., N.D.-R., B.J.), U1085-Institut de Recherche en Sant\u00e9, Environnement et Travail, Universit\u00e9 de Rennes 1, Structure F\u00e9d\u00e9rative Recherche Biosit, F-35042 Rennes, France"},{"name":"\u00c9cole des Hautes \u00c9tudes en Sant\u00e9 Publique\u2212School of Public Health (B.J.), F-35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041115285784900_B1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/351117a0","article-title":"Male development of chromosomally female mice transgenic for Sry","volume":"351","author":"Koopman","year":"1991","journal-title":"Nature"},{"key":"2019041115285784900_B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/eje.0.1300025","article-title":"Fetal testis\u2014a very special endocrine organ","volume":"130","author":"Huhtaniemi","year":"1994","journal-title":"Eur J Endocrinol"},{"key":"2019041115285784900_B3","first-page":"1","article-title":"Studies on sex differentiation in mammals","volume":"29","author":"Jost","year":"1973","journal-title":"Recent Prog Horm Res"},{"key":"2019041115285784900_B4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.yhbeh.2009.03.011","article-title":"The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues","volume":"55","author":"Arnold","year":"2009","journal-title":"Horm Behav"},{"key":"2019041115285784900_B5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/10364","article-title":"Cryptorchidism in mice mutant for Insl3","volume":"22","author":"Nef","year":"1999","journal-title":"Nat Genet"},{"key":"2019041115285784900_B6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1098-2795(199912)54:4<319::AID-MRD1>3.0.CO;2-Z","article-title":"Structure and expression of the rat relaxin-like factor (RLF) gene","volume":"54","author":"Spiess","year":"1999","journal-title":"Mol Reprod Dev"},{"key":"2019041115285784900_B7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","author":"Zimmermann","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041115285784900_B8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrurol.2011.23","article-title":"Testicular descent: INSL3, testosterone, genes and the intrauterine milieu","volume":"8","author":"Bay","year":"2011","journal-title":"Nat Rev Urol"},{"key":"2019041115285784900_B9","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1073\/pnas.83.12.4346","article-title":"The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice","volume":"83","author":"Gupta","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041115285784900_B10","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/sj.emboj.7600660","article-title":"Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation","volume":"24","author":"Malki","year":"2005","journal-title":"EMBO J"},{"key":"2019041115285784900_B11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/humupd\/dmm027","article-title":"Epidemiology and pathogenesis of cryptorchidism","volume":"14","author":"Virtanen","year":"2008","journal-title":"Hum Reprod Update"},{"key":"2019041115285784900_B12","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/humrep\/det111","article-title":"International geographic correlation study of the prevalence of disorders of male reproductive health","volume":"28","author":"Serrano","year":"2013","journal-title":"Hum Reprod"},{"key":"2019041115285784900_B13","first-page":"28","article-title":"Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data","volume":"55","author":"Lee","year":"2001","journal-title":"Horm Res"},{"key":"2019041115285784900_B14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00001648-199601000-00004","article-title":"Genital anomalies and risk for testicular cancer in Danish men","volume":"7","author":"Prener","year":"1996","journal-title":"Epidemiology"},{"key":"2019041115285784900_B15","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1210\/er.2007-0042","article-title":"Role of hormones, genes, and environment in human cryptorchidism","volume":"29","author":"Foresta","year":"2008","journal-title":"Endocr Rev"},{"key":"2019041115285784900_B16","first-page":"741","article-title":"Male reproductive health and environmental xenoestrogens","volume":"104","author":"Toppari","year":"1996","journal-title":"Environ Health Perspect"},{"key":"2019041115285784900_B17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jchromb.2013.02.023","article-title":"Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow\/reversed phase liquid chromatography","volume":"925","author":"Modick","year":"2013","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2019041115285784900_B18","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/humrep\/det112","article-title":"Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro","volume":"28","author":"Albert","year":"2013","journal-title":"Hum Reprod"},{"key":"2019041115285784900_B19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/humrep\/deq323","article-title":"Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat","volume":"26","author":"Kristensen","year":"2011","journal-title":"Hum Reprod"},{"key":"2019041115285784900_B20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/EDE.0b013e3181f20bed","article-title":"Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism","volume":"21","author":"Jensen","year":"2010","journal-title":"Epidemiology"},{"key":"2019041115285784900_B21","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/humrep\/der474","article-title":"Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study","volume":"27","author":"Snijder","year":"2012","journal-title":"Hum Reprod"},{"key":"2019041115285784900_B22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-3016.1996.tb00024.x","article-title":"Risk factors for cryptorchidism: a nested case-control study","volume":"10","author":"Berkowitz","year":"1996","journal-title":"Paediatr Perinat Epidemiol"},{"key":"2019041115285784900_B23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/EDE.0b013e318225bf33","article-title":"Analgesics during pregnancy and undescended testis","volume":"22","author":"Philippat","year":"2011","journal-title":"Epidemiology"},{"key":"2019041115285784900_B24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2019041115285784900_B25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2605.2012.01282.x","article-title":"Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis","volume":"35","author":"Kristensen","year":"2012","journal-title":"Int J Androl"},{"key":"2019041115285784900_B26","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1289\/ehp.1002635","article-title":"Many putative endocrine disruptors inhibit prostaglandin synthesis","volume":"119","author":"Kristensen","year":"2011","journal-title":"Environ Health Perspect"},{"key":"2019041115285784900_B27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1289\/ehp.9490","article-title":"Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human","volume":"115","author":"Hallmark","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2019041115285784900_B28","doi-asserted-by":"crossref","first-page":"31405","DOI":"10.1074\/jbc.M501489200","article-title":"Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system","volume":"280","author":"H\u00f6gest\u00e4tt","year":"2005","journal-title":"J Biol Chem"},{"key":"2019041115285784900_B29","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1001\/archinte.1982.00340250097015","article-title":"Ketoconazole blocks testosterone synthesis","volume":"142","author":"Pont","year":"1982","journal-title":"Arch Intern Med"},{"key":"2019041115285784900_B30","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/0002-9378(86)90173-0","article-title":"Acetaminophen pharmacokinetics: comparison between pregnant and nonpregnant women","volume":"155","author":"Rayburn","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"2019041115285784900_B31","first-page":"182","article-title":"Placental transfer of paracetamol","volume":"87","author":"Naga Rani","year":"1989","journal-title":"J Indian Med Assoc"},{"key":"2019041115285784900_B32","first-page":"192","article-title":"Bioavailability of aspirin after oral and rectal administration in volunteers and patients with fever","volume":"31","author":"Dalvi","year":"1985","journal-title":"J Postgrad Med"},{"key":"2019041115285784900_B33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1289\/ehp.11146","article-title":"Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production","volume":"117","author":"Lambrot","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2019041115285784900_B34","doi-asserted-by":"crossref","first-page":"e3285","DOI":"10.1371\/journal.pone.0003285","article-title":"Essential roles of COUP-TFII in Leydig cell differentiation and male fertility","volume":"3","author":"Qin","year":"2008","journal-title":"PLoS One"},{"key":"2019041115285784900_B35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfr132","article-title":"Characterization of novel ligands of ER\u03b1, ER\u03b2, and PPAR\u03b3: the case of halogenated bisphenol A and their conjugated metabolites","volume":"122","author":"Riu","year":"2011","journal-title":"Toxicol Sci"},{"key":"2019041115285784900_B36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/toxsci\/kfg065","article-title":"Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture","volume":"73","author":"Lassurgu\u00e8re","year":"2003","journal-title":"Toxicol Sci"},{"key":"2019041115285784900_B37","doi-asserted-by":"crossref","first-page":"e61726","DOI":"10.1371\/journal.pone.0061726","article-title":"Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts","volume":"8","author":"Mitchell","year":"2013","journal-title":"PLoS One"},{"key":"2019041115285784900_B38","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/humrep\/den038","article-title":"Insulin-like factor 3 levels in amniotic fluid of human male fetuses","volume":"23","author":"Anand-Ivell","year":"2008","journal-title":"Hum Reprod"},{"key":"2019041115285784900_B39","first-page":"901","article-title":"Comparison of testis structure, function and thyroid hormone levels in control C57BL\/6 mice and anti-Mullerian hormone over expressing mice","volume":"25","author":"Mendis-Handagama","year":"2010","journal-title":"Histol Histopathol"},{"key":"2019041115285784900_B40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/345167a0","article-title":"Abnormal sexual development in transgenic mice chronically expressing m\u00fcllerian inhibiting substance","volume":"345","author":"Behringer","year":"1990","journal-title":"Nature"},{"key":"2019041115285784900_B41","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/BF00179676","article-title":"Failure of gubernacular development in the persistent m\u00fcllerian duct syndrome allows herniation of the testes","volume":"9","author":"Hutson","year":"1994","journal-title":"Pediatr Surg Int"},{"key":"2019041115285784900_B42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(94)90251-8","article-title":"M\u00fcllerian-inhibiting substance function during mammalian sexual development","volume":"79","author":"Behringer","year":"1994","journal-title":"Cell"},{"key":"2019041115285784900_B43","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1460-9592.2008.02764.x","article-title":"Paracetamol (acetaminophen): mechanisms of action","volume":"18","author":"Anderson","year":"2008","journal-title":"Paediatr Anaesth"},{"key":"2019041115285784900_B44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/humu.22231","article-title":"Unilateral cryptorchidism in mice mutant for Ptgds","volume":"34","author":"Philibert","year":"2013","journal-title":"Hum Mutat"},{"key":"2019041115285784900_B45","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0024-3205(99)00063-6","article-title":"The inhibitor of phospholipase-A2, AACOCF3, stimulates steroid secretion by dispersed human and rat adrenocortical cells","volume":"64","author":"Andreis","year":"1999","journal-title":"Life Sci"},{"key":"2019041115285784900_B46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/bj2190529","article-title":"Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis","volume":"219","author":"Dix","year":"1984","journal-title":"Biochem J"},{"key":"2019041115285784900_B47","doi-asserted-by":"crossref","first-page":"e62556","DOI":"10.1371\/journal.pone.0062556","article-title":"Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin","volume":"8","author":"Dean","year":"2013","journal-title":"PLoS One"},{"key":"2019041115285784900_B48","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1074\/jbc.272.6.3406","article-title":"Peroxisome proliferator-activated receptors \u03b1 and \u03b3 are activated by indomethacin and other non-steroidal anti-inflammatory drugs","volume":"272","author":"Lehmann","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041115285784900_B49","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJM199505253322104","article-title":"Fertility in men exposed prenatally to diethylstilbestrol","volume":"332","author":"Wilcox","year":"1995","journal-title":"N Engl J Med"},{"key":"2019041115285784900_B50","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J Clin Invest"},{"key":"2019041115285784900_B51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1472-8206.2011.01010.x","article-title":"Paracetamol and opioid pathways: a pilot randomized clinical trial","volume":"27","author":"Pickering","year":"2013","journal-title":"Fundam Clin Pharmacol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/98\/11\/E1757\/10781676\/jcem1757.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:36:40Z","timestamp":1555033000000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/98\/11\/E1757\/2834532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-2531","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}