{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:36Z","timestamp":1790752116155,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"DOI":"10.1210\/jc.2013-2565","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T12:53:44Z","timestamp":1390913624000},"page":"E582-E590","source":"Crossref","is-referenced-by-count":42,"title":["Role of Sclerostin and Dickkopf-1 in the Dramatic Alteration in Bone Mass Acquisition in Adolescents and Young Women With Recent Anorexia Nervosa"],"prefix":"10.1210","volume":"99","author":[{"given":"Laurent","family":"Ma\u00efmoun","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire (L.M., D.M.-G.), 34295 Montpellier, France;"},{"name":"H\u00f4pital Lapeyronie, Centre Hospitalier Regional Universitaire (CHRU) Montpellier et Universit\u00e9 Montpellier 1 (UMI); Service d'Hormonologie (L.M., P.P., F.P., C.S.), 34295 Montpellier, France;"},{"name":"H\u00f4pital Lapeyronie, CHRU Montpellier and UM1, Inserm Unit\u00e9 (U) 1061; Physiologie et M\u00e9decine Exp\u00e9rimentale du C\u0153ur et des Muscles (L.M.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Guillaume","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, CHRU Montpellier; D\u00e9partement d'Urgence et Post-Urgence Psychiatrique (S.G., P.C.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie, Diab\u00e8te, Nutrition (P.L., J.B., E.R.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Philibert","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, Centre Hospitalier Regional Universitaire (CHRU) Montpellier et Universit\u00e9 Montpellier 1 (UMI); Service d'Hormonologie (L.M., P.P., F.P., C.S.), 34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Bertet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique et Epid\u00e9miologie (H.B., M.-C.P.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Picot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique et Epid\u00e9miologie (H.B., M.-C.P.),34295 Montpellier, France;"},{"name":"Inserm U1046, UM1 and UM2; Centre d'Investigation Clinique (CIC) Inserm 1411 (M.-C.P., E.R.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gaspari","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie (L.G.), H\u00f4pital Caremeau, CHRU N\u00eemes, 30000 N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Paris","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, Centre Hospitalier Regional Universitaire (CHRU) Montpellier et Universit\u00e9 Montpellier 1 (UMI); Service d'Hormonologie (L.M., P.P., F.P., C.S.), 34295 Montpellier, France;"},{"name":"H\u00f4pital Gui de Chauliac, CHRU Montpellier; Unit\u00e9 d'Endocrinologie et Gyn\u00e9cologie P\u00e9diatrique (F.P., C.S.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, CHRU Montpellier; D\u00e9partement d'Urgence et Post-Urgence Psychiatrique (S.G., P.C.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thomas","sequence":"additional","affiliation":[{"name":"et Service de Rhumatologie (E.T.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mariano-Goulart","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire (L.M., D.M.-G.), 34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bringer","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie, Diab\u00e8te, Nutrition (P.L., J.B., E.R.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie, Diab\u00e8te, Nutrition (P.L., J.B., E.R.),34295 Montpellier, France;"},{"name":"Inserm U1046, UM1 and UM2; Centre d'Investigation Clinique (CIC) Inserm 1411 (M.-C.P., E.R.),34295 Montpellier, France;"},{"name":"D\u00e9partement de P\u00e9diatrie, H\u00f4pital Arnaud de Villeneuve, CHRU Montpellier et UM1; and Institut de G\u00e9nomique Fonctionnelle (E.R.),Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 5203\/Inserm U661\/UM1 and UM2, 34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sultan","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, Centre Hospitalier Regional Universitaire (CHRU) Montpellier et Universit\u00e9 Montpellier 1 (UMI); Service d'Hormonologie (L.M., P.P., F.P., C.S.), 34295 Montpellier, France;"},{"name":"H\u00f4pital Gui de Chauliac, CHRU Montpellier; Unit\u00e9 d'Endocrinologie et Gyn\u00e9cologie P\u00e9diatrique (F.P., C.S.),34295 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114105678500_B1","first-page":"898","article-title":"The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa","volume":"80","author":"Klibanski","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B2","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1210\/jc.2003-030532","article-title":"Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism","volume":"88","author":"Misra","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00223-007-9038-9","article-title":"Evaluation of bone loss and its mechanisms in anorexia nervosa","volume":"81","author":"Legroux-G\u00e9rot","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041114105678500_B4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1210\/jc.2007-1591","article-title":"Constitutional thinness: unusual human phenotype of low bone quality","volume":"93","author":"Galusca","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B5","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","article-title":"Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa","volume":"133","author":"Grinspoon","year":"2000","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041114105678500_B6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","article-title":"The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication","volume":"61","author":"Hudson","year":"2007","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t2019041114105678500_B7","first-page":"1060","article-title":"Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects","volume":"75","author":"Theintz","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B8","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bone.2011.02.010","article-title":"Effect of maturational timing on bone mineral content accrual from childhood to adulthood: evidence from 15 years of longitudinal data","volume":"48","author":"Jackowski","year":"2011","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114105678500_B9","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1359\/jbmr.1998.13.10.1602","article-title":"A longitudinal study of bone gain in pubertal girls: anthropometric and biochemical correlates","volume":"13","author":"Cadogan","year":"1998","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B10","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1210\/jc.2003-030088","article-title":"Serum osteoprotegerin in adolescent girls with anorexia nervosa","volume":"88","author":"Misra","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B11","first-page":"4489","article-title":"The effects of anorexia nervosa on bone metabolism in female adolescents","volume":"84","author":"Soyka","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bone.2007.03.018","article-title":"Skeletal status and laboratory investigations in adolescent girls with anorexia nervosa","volume":"41","author":"Oswiecimska","year":"2007","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114105678500_B13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00198-004-1759-2","article-title":"Cortical and trabecular bone density and structure in anorexia nervosa","volume":"16","author":"Milos","year":"2005","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041114105678500_B14","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0025-6196(11)63994-3","article-title":"Long-term fracture risk among women with anorexia nervosa: a population-based cohort study","volume":"74","author":"Lucas","year":"1999","journal-title":"Mayo Clin Proc"},{"key":"key\n\t\t\t\t2019041114105678500_B15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2265.2000.00879.x","article-title":"Weight gain reverses bone turnover and restores circadian variation of bone resorption in anorexic patients","volume":"52","author":"Caillot-Augusseau","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114105678500_B16","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2007-0270","article-title":"Targeting the Wnt\/\u03b2-catenin pathway to regulate bone formation in the adult skeleton","volume":"148","author":"Baron","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041114105678500_B17","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI28551","article-title":"Regulation of bone mass by Wnt signaling","volume":"116","author":"Krishnan","year":"2006","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041114105678500_B18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.109.164129","article-title":"The application of target information and preclinical pharmacokinetic\/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis","volume":"333","author":"Betts","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t2019041114105678500_B19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","article-title":"Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis","volume":"24","author":"Li","year":"2009","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B21","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1210\/jc.2011-0380","article-title":"Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study","volume":"96","author":"Miller","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B22","article-title":"A manual of cutaneous medicine","author":"Pillsbury","year":"1961"},{"key":"key\n\t\t\t\t2019041114105678500_B23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(09)61748-7","article-title":"Eating disorders","volume":"375","author":"Treasure","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041114105678500_B24","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/jbmr.447","article-title":"Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa","volume":"26","author":"Misra","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B25","first-page":"2395","article-title":"Pubertal adipose tissue: is it necessary for normal sexual maturation? Evidence from the rat and human female","volume":"39","author":"Frisch","year":"1980","journal-title":"Fed Proc"},{"key":"key\n\t\t\t\t2019041114105678500_B26","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1210\/jc.2013-1070","article-title":"Specific bone mass acquisition in elite female athletes","volume":"98","author":"Ma\u00efmoun","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2265.2002.01573.x","article-title":"Bone metabolism markers and bone mass in healthy pubertal boys and girls","volume":"57","author":"van Coeverden","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114105678500_B28","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bone.2012.06.006","article-title":"Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls","volume":"51","author":"Faje","year":"2012","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114105678500_B29","first-page":"200","article-title":"The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa","volume":"85","author":"Hotta","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbmr.217","article-title":"Relation of age, gender, and bone mass to circulating sclerostin levels in women and men","volume":"26","author":"M\u00f6dder","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B31","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1210\/jc.2009-2283","article-title":"Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women","volume":"95","author":"Mirza","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jbmr.128","article-title":"Regulation of circulating sclerostin levels by sex steroids in women and in men","volume":"26","author":"M\u00f6dder","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B33","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00198-011-1669-z","article-title":"Sclerostin levels during growth in children","volume":"23","author":"Kirmani","year":"2012","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041114105678500_B34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2005.03.018","article-title":"SOST is a target gene for PTH in bone","volume":"37","author":"Keller","year":"2005","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114105678500_B35","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1210\/jc.2010-0720","article-title":"Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women","volume":"95","author":"Drake","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B36","doi-asserted-by":"crossref","first-page":"e25900","DOI":"10.1371\/journal.pone.0025900","article-title":"Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway","volume":"6","author":"Wijenayaka","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041114105678500_B37","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041114105678500_B38","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/jc.2008-2532","article-title":"Increased bone marrow fat in anorexia nervosa","volume":"94","author":"Bredella","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114105678500_B39","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bone.2011.11.028","article-title":"Bisphosphonate treatment of postmenopausal osteoporosis is associated with a dose dependent increase in serum sclerostin","volume":"50","author":"Gatti","year":"2012","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114105678500_B40","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/jbmr.1681","article-title":"Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab","volume":"27","author":"Gatti","year":"2012","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114105678500_B41","article-title":"Diagnostic and statistical manual of mental disorders 4th ed (DSM-IV)","author":"American Psychiatric Association","year":"1994"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/4\/E582\/9050287\/jcemE582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T23:18:46Z","timestamp":1565133526000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/4\/E582\/2537619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-2565","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}