{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:24:43Z","timestamp":1780586683337,"version":"3.54.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1210\/jc.2013-2572","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:05:57Z","timestamp":1384815957000},"page":"469-477","source":"Crossref","is-referenced-by-count":33,"title":["Associations Between Bone Mineral Density and Subclinical Atherosclerosis: A Cross-Sectional Study of a Chinese Population"],"prefix":"10.1210","volume":"99","author":[{"given":"Dong-Ke","family":"Liang","sequence":"first","affiliation":[{"name":"Departments of Gerontology and Geriatrics (D.-K.L., B.W., X.-N.W.), Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Bai","sequence":"additional","affiliation":[{"name":"Departments of Gerontology and Geriatrics (X.-J.B., L.-L.H.), Sheng Jing Hospital, China Medical University, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Gerontology and Geriatrics (D.-K.L., B.W., X.-N.W.), Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Departments of Gerontology and Geriatrics (X.-J.B., L.-L.H.), Sheng Jing Hospital, China Medical University, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Gerontology and Geriatrics (D.-K.L., B.W., X.-N.W.), Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiac Function (J.Y.), the First Affiliated Hospital, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Kidney (X.-M.C.), General Hospital of Chinese People's Liberation Army, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113502326400_B1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1359\/jbmr.090531","article-title":"Increased bone resorption is associated with increased risk of cardiovascular events in men: The MINOS Study","volume":"24","author":"Szulc","year":"2009","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113502326400_B2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.amjcard.2007.12.013","article-title":"Relation of bone mineral density to frequency of coronary heart disease","volume":"101","author":"Varma","year":"2008","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113502326400_B3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.amjcard.2009.03.016","article-title":"Relation of bone mineral density to stress test-induced myocardial ischemia","volume":"104","author":"Pierre-Louis","year":"2009","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113502326400_B4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/aje\/kwh080","article-title":"Metacarpal cortical area and risk of coronary heart disease: the Framingham Study","volume":"159","author":"Samelson","year":"2004","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019041113502326400_B5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/aje\/kwn303","article-title":"Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study","volume":"169","author":"Hyder","year":"2009","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019041113502326400_B6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1359\/jbmr.070903","article-title":"Calcifications in the abdominal aorta predict fractures in men: MINOS study","volume":"23","author":"Szulc","year":"2008","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113502326400_B7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00223-007-9004-6","article-title":"Association between systemic calcified atherosclerosis and bone density","volume":"80","author":"Hyder","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113502326400_B8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jbmr.5650100306","article-title":"Sources of interracial variation in bone mineral density","volume":"10","author":"Cundy","year":"1995","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113502326400_B9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s002230001139","article-title":"Bone mineral density differences at the femoral neck and Ward's triangle: a comparison study on the reference data between Chinese and Caucasian women","volume":"67","author":"Xiaoge","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113502326400_B10","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00198-005-1968-3","article-title":"Bone mineral density and the risk of peripheral arterial disease in men and women: results from Mr. and Ms Os, Hong Kong","volume":"16","author":"Wong","year":"2005","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113502326400_B11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00774-008-0014-x","article-title":"Association between lumbar bone mineral density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women","volume":"27","author":"Mikumo","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"key\n\t\t\t\t2019041113502326400_B12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.maturitas.2006.02.008","article-title":"Elevated arterial stiffness in postmenopausal women with osteoporosis","volume":"55","author":"Sumino","year":"2006","journal-title":"Maturitas"},{"key":"key\n\t\t\t\t2019041113502326400_B13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/gme.0b013e3181a15552","article-title":"Bone mineral density, arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women","volume":"16","author":"Seo","year":"2009","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113502326400_B14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.atherosclerosis.2005.10.036","article-title":"Associations between physical activity, peripheral atherosclerosis and bone status in healthy Japanese women","volume":"188","author":"Yamada","year":"2006","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113502326400_B15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113502326400_B16","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1681\/ASN.2006040368","article-title":"Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease","volume":"17","author":"Ma","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2019041113502326400_B17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S8756-3282(00)00242-8","article-title":"Annual skeletal balance and metabolic bone marker changes in healthy early postmenopausal women: results of a prospective study","volume":"26","author":"Mazzuoli","year":"2000","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113502326400_B18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00198-004-1699-x","article-title":"Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover","volume":"16","author":"Indridason","year":"2005","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113502326400_B19","first-page":"369","article-title":"Regression diagnostics","volume-title":"Applied Regression Analysis: A Research Tool","author":"Rawlings","year":"1998","edition":"2nd ed"},{"key":"key\n\t\t\t\t2019041113502326400_B20","first-page":"636","article-title":"Exploratory factor analysis","volume-title":"Discovering Statistics Using SPSS","author":"Field","year":"2009","edition":"3rd ed"},{"key":"key\n\t\t\t\t2019041113502326400_B21","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.pmrj.2009.10.004","article-title":"The problem of multiple testing","volume":"1","author":"Sainani","year":"2009","journal-title":"PM R"},{"key":"key\n\t\t\t\t2019041113502326400_B22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00223-001-2076-9","article-title":"Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study","volume":"70","author":"van der Klift","year":"2002","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113502326400_B23","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1161\/CIRCULATIONAHA.108.820993","article-title":"Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men","volume":"119","author":"Collins","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113502326400_B24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2009.09.011","article-title":"Bone mineral density and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis, Abdominal Aortic Calcium Study","volume":"209","author":"Hyder","year":"2010","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113502326400_B25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1359\/jbmr.1997.12.2.283","article-title":"Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures","volume":"12","author":"Vogt","year":"1997","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113502326400_B26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00223-008-9153-2","article-title":"Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening","volume":"83","author":"Frost","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113502326400_B27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00198-008-0648-5","article-title":"Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?","volume":"20","author":"Anagnostis","year":"2009","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113502326400_B28","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.2337\/db10-1220","article-title":"The RANKL\/RANK\/OPG signaling pathway mediates medial arterial calcification in diabetic Charcot neuroarthropathy","volume":"60","author":"Ndip","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113502326400_B29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCRESAHA.110.216846","article-title":"Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification","volume":"107","author":"Osako","year":"2010","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113502326400_B30","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"Minireview: the OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113502326400_B31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/CIRCRESAHA.108.189001","article-title":"RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway","volume":"104","author":"Panizo","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019041113502326400_B32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/B978-1-4377-1604-7.00070-1","article-title":"Atherosclerosis, thrombosis, and vascular biology","volume-title":"Goldman's Cecil Medicine","author":"Hansson","year":"2012","edition":"24th ed"},{"key":"key\n\t\t\t\t2019041113502326400_B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP.16.S3.1","article-title":"American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis","volume":"3","author":"Watts","year":"2010","journal-title":"Endocr Pract"},{"key":"key\n\t\t\t\t2019041113502326400_B34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5114\/aoms.2011.22077","article-title":"Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women","volume":"7","author":"Yazici","year":"2011","journal-title":"Arch Med Sci"},{"key":"key\n\t\t\t\t2019041113502326400_B35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bone.2008.09.020","article-title":"Association between serum cholesterol and bone mineral density","volume":"44","author":"Makovey","year":"2009","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113502326400_B36","doi-asserted-by":"crossref","first-page":"E1296","DOI":"10.1152\/ajpendo.00085.2012","article-title":"Elevation of fibrinogen due to loss of ovarian function enhances actin ring formation and leads to increased bone resorption","volume":"303","author":"Ke","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113502326400_B37","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00198-005-1840-5","article-title":"Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis","volume":"16","author":"Koh","year":"2005","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2019041113502326400_B38","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bone.2012.10.025","article-title":"Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study","volume":"52","author":"Makovey","year":"2013","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113502326400_B39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5114\/aoms.2011.22066","article-title":"Association between atherosclerosis and osteoporosis, the role of vitamin D","volume":"7","author":"Stojanovic","year":"2011","journal-title":"Arch Med Sci"},{"key":"key\n\t\t\t\t2019041113502326400_B40","first-page":"93","article-title":"Causal inference and extraneous factors: confounding and interaction","volume-title":"Statistics for Epidemiology","author":"Jewell","year":"2004"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/2\/469\/9045470\/jcem0469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T08:32:55Z","timestamp":1564734775000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/2\/469\/2536876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-2572","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}