{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T20:17:25Z","timestamp":1773519445842,"version":"3.50.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"DOI":"10.1210\/jc.2013-2686","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T16:12:00Z","timestamp":1394467920000},"page":"2008-2017","source":"Crossref","is-referenced-by-count":111,"title":["Altered Islet Function and Insulin Clearance Cause Hyperinsulinemia in Gastric Bypass Patients With Symptoms of Postprandial Hypoglycemia"],"prefix":"10.1210","volume":"99","author":[{"given":"Marzieh","family":"Salehi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati College of Medicine (M.S., D.A.D.), Cincinnati, Ohio 45219;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Cardiometabolic Risk Unit (A.G.), Institute of Clinical Physiology, 56124 Pisa, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"D'Alessio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati College of Medicine (M.S., D.A.D.), Cincinnati, Ohio 45219;"},{"name":"Cincinnati VA Medical Center (D.A.D.), Cincinnati, Ohio 45220"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113544166900_B1","doi-asserted-by":"crossref","first-page":"E122","DOI":"10.1152\/ajpendo.00073.2012","article-title":"Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with type 2 diabetes and normal glucose tolerance","volume":"303","author":"J\u00f8rgensen","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B2","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1210\/jc.2007-0918","article-title":"Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal","volume":"92","author":"Goldfine","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B3","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.2337\/db11-0203","article-title":"Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans","volume":"60","author":"Salehi","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1007\/s00464-010-1489-9","article-title":"Abnormal glucose tolerance testing following gastric bypass demonstrates reactive hypoglycemia","volume":"25","author":"Roslin","year":"2011","journal-title":"Surg Endosc"},{"key":"key\n\t\t\t\t2019041113544166900_B5","first-page":"442","article-title":"Hypoglycemias","volume":"154","author":"Service","year":"1991","journal-title":"West J Med"},{"key":"key\n\t\t\t\t2019041113544166900_B6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jc.2008-1410","article-title":"Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline","volume":"94","author":"Cryer","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.0954-6820.1970.tb08072.x","article-title":"A clinical diagnostic index in the diagnosis of the dumping syndrome. Changes in plasma volume and blood sugar after a test meal","volume":"188","author":"Sigstad","year":"1970","journal-title":"Acta Med Scand"},{"key":"key\n\t\t\t\t2019041113544166900_B8","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.2337\/db11-1825","article-title":"Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test","volume":"61","author":"Salehi","year":"2012","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B9","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.2337\/db09-1253","article-title":"Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes","volume":"59","author":"Salehi","year":"2010","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B10","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diabetes.41.3.368","article-title":"Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance","volume":"41","author":"Van Cauter","year":"1992","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2337\/diab.37.2.200","article-title":"Incretin effect due to increased secretion and decreased clearance of insulin in normal humans","volume":"37","author":"Shuster","year":"1988","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B12","first-page":"E349","article-title":"Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans","volume":"254","author":"Tillil","year":"1988","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113544166900_B13","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1007\/s00125-006-0337-x","article-title":"Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and \u03b2 cell function","volume":"49","author":"Mari","year":"2006","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113544166900_B14","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.metabol.2013.05.001","article-title":"Eight weeks of treatment with long-acting GLP-1 analog taspoglutide improves postprandial insulin secretion and sensitivity in metformin-treated patients with type 2 diabetes","volume":"62","author":"Gastaldelli","year":"2013","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113544166900_B15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/cen.12199","article-title":"The effect of chronic twice daily exenatide treatment on beta-cell function in new onset type 2 diabetes","volume":"80","author":"Gastaldelli","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113544166900_B16","doi-asserted-by":"crossref","first-page":"E1159","DOI":"10.1152\/ajpendo.00093.2002","article-title":"Meal and oral glucose tests for assessment of \u03b2-cell function: modeling analysis in normal subjects","volume":"283","author":"Mari","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B17","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1210\/jc.2008-1620","article-title":"Long-term effects of Roux-en-Y gastric bypass surgery on plasma glucagon-like peptide-1 and islet function in morbidly obese subjects","volume":"94","author":"Vidal","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B18","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/ijo.2009.79","article-title":"Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass","volume":"33","author":"Korner","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"key\n\t\t\t\t2019041113544166900_B19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s11695-012-0621-4","article-title":"Changes in gastrointestinal hormone responses, insulin sensitivity, and \u03b2-cell function within 2 weeks after gastric bypass in non-diabetic subjects","volume":"22","author":"Jacobsen","year":"2012","journal-title":"Obes Surg"},{"key":"key\n\t\t\t\t2019041113544166900_B20","first-page":"E67","article-title":"Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction","volume":"260","author":"Mitrakou","year":"1991","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113544166900_B21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2337\/diacare.14.11.949","article-title":"Symptoms of acute insulin-induced hypoglycemia in humans with and without IDDM. Factor-analysis approach","volume":"14","author":"Hepburn","year":"1991","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113544166900_B22","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1007\/s00125-005-1933-x","article-title":"Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia","volume":"48","author":"Patti","year":"2005","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113544166900_B23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1056\/NEJMoa043690","article-title":"Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery","volume":"353","author":"Service","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113544166900_B24","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s11695-008-9480-4","article-title":"Severe recurrent hypoglycemia after gastric bypass surgery","volume":"18","author":"Z'graggen","year":"2008","journal-title":"Obes Surg"},{"key":"key\n\t\t\t\t2019041113544166900_B25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2337\/db13-0954","article-title":"Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass","volume":"63","author":"Shah","year":"2014","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B26","doi-asserted-by":"crossref","first-page":"E1372","DOI":"10.1210\/jc.2011-0446","article-title":"The role of \u03b2-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery","volume":"96","author":"Nannipieri","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B27","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.2337\/db13-0321","article-title":"Long-term effects of bariatric surgery on meal disposal and \u03b2-cell function in diabetic and nondiabetic patients","volume":"62","author":"Camastra","year":"2013","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113544166900_B28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI118441","article-title":"The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans","volume":"97","author":"Prigeon","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113544166900_B29","doi-asserted-by":"crossref","first-page":"E941","DOI":"10.1152\/ajpendo.90842.2008","article-title":"Minimal model assessment of hepatic insulin extraction during an oral test from standard insulin kinetic parameters","volume":"297","author":"Campioni","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B30","first-page":"E21","article-title":"Insulin secretion and clearance during low-dose graded glucose infusion","volume":"268","author":"Byrne","year":"1995","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113544166900_B31","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1210\/jcem.82.6.3979","article-title":"Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals","volume":"82","author":"Jones","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00125-002-0776-y","article-title":"Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance","volume":"45","author":"Ehrmann","year":"2002","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113544166900_B33","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1210\/jc.2007-2851","article-title":"Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes","volume":"93","author":"Laferr\u00e8re","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B34","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2337\/dc06-1549","article-title":"Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes","volume":"30","author":"Laferr\u00e8re","year":"2007","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113544166900_B35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/oby.2007.83","article-title":"Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release","volume":"16","author":"Rodieux","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"key\n\t\t\t\t2019041113544166900_B36","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1210\/jc.2010-2876","article-title":"Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides","volume":"96","author":"Falk\u00e9n","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113544166900_B37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.sla.0000183349.16877.84","article-title":"Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters","volume":"243","author":"le Roux","year":"2006","journal-title":"Ann Surg"},{"key":"key\n\t\t\t\t2019041113544166900_B38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/oby.2009.473","article-title":"Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding","volume":"18","author":"Bose","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"key\n\t\t\t\t2019041113544166900_B39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/bjs.5227","article-title":"Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety","volume":"93","author":"Borg","year":"2006","journal-title":"Br J Surg"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/6\/2008\/9048055\/jcem2008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:04:41Z","timestamp":1565255081000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/6\/2008\/2537603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-2686","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]}}}