{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:44:50Z","timestamp":1792640690955,"version":"4.5.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Loss-of-function mutations in makorin ring finger 3 (MKRN3), an imprinted gene located on the long arm of chromosome 15, have been recognized recently as a cause of familial central precocious puberty (CPP) in humans. MKRN3 has a potential inhibitory effect on GnRH secretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>The objective of the study was to investigate potential MKRN3 sequence variations as well as copy number and methylation abnormalities of the 15q11 locus in patients with apparently sporadic CPP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting and Participants:<\/jats:title>\n                  <jats:p>We studied 215 unrelated children (207 girls and eight boys) from three university medical centers with a diagnosis of CPP. All but two of these patients (213 cases) reported no family history of premature sexual development. First-degree relatives of patients with identified MKRN3 variants were included for genetic analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>All 215 CPP patients were screened for MKRN3 mutations by automatic sequencing. Multiplex ligation-dependent probe amplification was performed in a partially overlapping cohort of 52 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>We identified five novel heterozygous mutations in MKRN3 in eight unrelated girls with CPP. Four were frame shift mutations predicted to encode truncated proteins and one was a missense mutation, which was suggested to be deleterious by in silico analysis. All patients with MKRN3 mutations had classical features of CPP with a median age of onset at 6 years. Copy number and methylation abnormalities at the 15q11 locus were not detected in the patients tested for these abnormalities. Segregation analysis was possible in five of the eight girls with MKRN3 mutations; in all cases, the mutation was inherited on the paternal allele.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>We have identified novel inherited MKRN3 defects in children with apparently sporadic CPP, supporting a fundamental role of this peptide in the suppression of the reproductive axis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2013-3126","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T15:28:21Z","timestamp":1394810901000},"page":"E1097-E1103","source":"Crossref","is-referenced-by-count":122,"title":["Central Precocious Puberty That Appears to Be Sporadic Caused by Paternally Inherited Mutations in the Imprinted Gene Makorin Ring Finger 3"],"prefix":"10.1210","volume":"99","author":[{"given":"Delanie B.","family":"Macedo","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Abreu","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"},{"name":"Division of Endocrinology, Diabetes, and Hypertension (A.P.A., R.S.C., U.B.K.),Cambridge, Massachusetts 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia S.","family":"Reis","sequence":"first","affiliation":[{"name":"Departamento de Puericultura e Pediatria (A.C.S.R., M.C., A.C.M., C.E.M., S.R.A.), Faculdade de Medicina de Ribeir\u00e3o Preto, da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brasil, 14049900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana R.","family":"Montenegro","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dauber","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School and Division of Endocrinology, (A.D., J.N.H.) Boston Children's Hospital, Boston, Massachusetts 02115,Cambridge, Massachusetts 02142;"},{"name":"Program in Medical and Population Genetics Broad Institute (A.D., J.N.H.), Cambridge, Massachusetts 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane","family":"Beneduzzi","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Cukier","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia F. G.","family":"Silveira","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena G.","family":"Teles","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona S.","family":"Carroll","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension (A.P.A., R.S.C., U.B.K.),Cambridge, Massachusetts 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Guerra","family":"Junior","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia Pedi\u00e1trica (G.G.J., G.G.F.), Universidade de Campinas, SP, Brasil, 13084-970;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Guaragna","family":"Filho","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia Pedi\u00e1trica (G.G.J., G.G.F.), Universidade de Campinas, SP, Brasil, 13084-970;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Gucev","sequence":"first","affiliation":[{"name":"Medical Faculty Skopje (Z.G.), 50 Divizija BB, 1000 Skopje, Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo J. P.","family":"Arnhold","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"de Castro","sequence":"first","affiliation":[{"name":"Departamento de Puericultura e Pediatria (A.C.S.R., M.C., A.C.M., C.E.M., S.R.A.), Faculdade de Medicina de Ribeir\u00e3o Preto, da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brasil, 14049900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrton C.","family":"Moreira","sequence":"first","affiliation":[{"name":"Departamento de Puericultura e Pediatria (A.C.S.R., M.C., A.C.M., C.E.M., S.R.A.), Faculdade de Medicina de Ribeir\u00e3o Preto, da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brasil, 14049900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Carlos Eduardo","family":"Martinelli","sequence":"first","affiliation":[{"name":"Departamento de Puericultura e Pediatria (A.C.S.R., M.C., A.C.M., C.E.M., S.R.A.), Faculdade de Medicina de Ribeir\u00e3o Preto, da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brasil, 14049900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel N.","family":"Hirschhorn","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School and Division of Endocrinology, (A.D., J.N.H.) Boston Children's Hospital, Boston, Massachusetts 02115,Cambridge, Massachusetts 02142;"},{"name":"Program in Medical and Population Genetics Broad Institute (A.D., J.N.H.), Cambridge, Massachusetts 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B.","family":"Mendonca","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil, 05403-900;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius N.","family":"Brito","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Disciplina de Endocrinologia (D.B.M., 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