{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:18:52Z","timestamp":1789773532560,"version":"4.0.1"},"reference-count":20,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>Rationale:<\/jats:title>\n                  <jats:p>Metabolic syndrome (MetS) is a high-prevalence condition characterized by altered energy metabolism, insulin resistance, and elevated cardiovascular risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>Although many individual single nucleotide polymorphisms (SNPs) have been linked to certain MetS features, there are few studies analyzing the influence of SNPs on carbohydrate metabolism in MetS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A total of 904 SNPs (tag SNPs and functional SNPs) were tested for influence on 8 fasting and dynamic markers of carbohydrate metabolism, by performance of an intravenous glucose tolerance test in 450 participants in the LIPGENE study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings:<\/jats:title>\n                  <jats:p>From 382 initial gene-phenotype associations between SNPs and any phenotypic variables, 61 (16% of the preselected variables) remained significant after bootstrapping. Top SNPs affecting glucose metabolism variables were as follows: fasting glucose, rs26125 (PPARGC1B); fasting insulin, rs4759277 (LRP1); C-peptide, rs4759277 (LRP1); homeostasis assessment of insulin resistance, rs4759277 (LRP1); quantitative insulin sensitivity check index, rs184003 (AGER); sensitivity index, rs7301876 (ABCC9), acute insulin response to glucose, rs290481 (TCF7L2); and disposition index, rs12691 (CEBPA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>We describe here the top SNPs linked to phenotypic features in carbohydrate metabolism among approximately 1000 candidate gene variations in fasting and postprandial samples of 450 patients with MetS from the LIPGENE study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2013-3165","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T04:36:14Z","timestamp":1383885374000},"page":"E384-E389","source":"Crossref","is-referenced-by-count":31,"title":["Top Single Nucleotide Polymorphisms Affecting Carbohydrate Metabolism in Metabolic Syndrome: From the LIPGENE Study"],"prefix":"10.1210","volume":"99","author":[{"given":"Javier","family":"Delgado-Lista","sequence":"first","affiliation":[{"name":"Lipids and Atherosclerosis Unit (J.D.-L., P.P-M., A.G.-R., A.I.P.-C., A.C., J.L.-M.), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Perez-Martinez","sequence":"first","affiliation":[{"name":"Lipids and Atherosclerosis Unit (J.D.-L., P.P-M., A.G.-R., A.I.P.-C., A.C., J.L.-M.), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Solivera","sequence":"first","affiliation":[{"name":"Department of Medicine, and Neurosurgery Unit (J.S.), Instituto Maim\u00f3nedes de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba\/Hospital Universitario Reina Sof\u00eda\/Universidad de C\u00f3rdoba, 14004 Cordoba, Spain and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Garcia-Rios","sequence":"first","affiliation":[{"name":"Lipids and Atherosclerosis Unit (J.D.-L., P.P-M., A.G.-R., A.I.P.-C., A.C., J.L.-M.), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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