{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:03:23Z","timestamp":1782057803164,"version":"3.54.5"},"reference-count":37,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:sec><jats:title>Context:<\/jats:title><jats:p>Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>This was a cross-sectional analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting:<\/jats:title><jats:p>The study was conducted at a clinical research center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients or Other Participants:<\/jats:title><jats:p>Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention:<\/jats:title><jats:p>Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure:<\/jats:title><jats:p>Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2013-3258","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T14:18:15Z","timestamp":1398781095000},"page":"2887-2896","source":"Crossref","is-referenced-by-count":20,"title":["Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia"],"prefix":"10.1210","volume":"99","author":[{"given":"Jessicah S.","family":"Collins","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908"},{"name":"Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.), Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer P.","family":"Beller","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908"},{"name":"Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.), Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Burt Solorzano","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908"},{"name":"Pediatrics (C.B.S.), Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Patrie","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences (J.T.P.), University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jeffrey","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (R.J.C.), Department of Reproductive Medicine, University of California, San Diego, San Diego, California 92103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Marshall","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908"},{"name":"Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.), Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"McCartney","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Charlottesville, Virginia 22908"},{"name":"Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.), Charlottesville, Virginia 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Metab"},{"key":"2020071613141074600_B4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/jc.2008-1252","article-title":"Maturation of luteinizing hormone (gonadotropin-releasing hormone) secretion across puberty: evidence for altered regulation in obese peripubertal girls","volume":"94","author":"McCartney","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613141074600_B5","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2004-2033","article-title":"Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase","volume":"90","author":"Hall","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613141074600_B6","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1210\/jc.2008-1655","article-title":"Blunted sleep-related luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index","volume":"94","author":"Bordini","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613141074600_B7","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1210\/jc.2012-4136","article-title":"Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test","volume":"98","author":"Rosenfield","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613141074600_B8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2826.2010.02029.x","article-title":"Maturation of sleep-wake gonadotrophin-releasing hormone secretion across puberty in girls: potential mechanisms and relevance to the pathogenesis of polycystic ovary syndrome","volume":"22","author":"McCartney","year":"2010","journal-title":"J Neuroendocrinology"},{"key":"2020071613141074600_B9","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and 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