{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:52:51Z","timestamp":1784155971171,"version":"3.55.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1210\/jc.2013-3278","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T23:47:47Z","timestamp":1386114467000},"page":"E252-E256","source":"Crossref","is-referenced-by-count":50,"title":["Serum Dickkopf 1 Levels in Sclerostin Deficiency"],"prefix":"10.1210","volume":"99","author":[{"given":"A. H.","family":"van Lierop","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases and Leiden Center for Bone Quality, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. C.","family":"Moester","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases and Leiden Center for Bone Quality, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A. T.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases and Leiden Center for Bone Quality, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Papapoulos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases and Leiden Center for Bone Quality, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113323828400_B1","first-page":"99","article-title":"Sclerostin: current knowledge and future perspectives","volume":"87","author":"Moester","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113323828400_B2","first-page":"19883","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113323828400_B3","first-page":"19489","article-title":"Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function","volume":"286","author":"Leupin","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113323828400_B4","first-page":"683","article-title":"Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow","volume":"3","author":"Bafico","year":"2001","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t2019041113323828400_B5","first-page":"664","article-title":"Kremen proteins are Dickkopf receptors that regulate Wnt\/\u03b2-catenin signalling","volume":"417","author":"Mao","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113323828400_B6","first-page":"2483","article-title":"The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma","volume":"349","author":"Tian","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113323828400_B7","first-page":"1433","article-title":"Wnt antagonists bind through a short peptide to the first \u03b2-propeller domain of LRP5\/6","volume":"19","author":"Bourhis","year":"2011","journal-title":"Structure"},{"key":"key\n\t\t\t\t2019041113323828400_B8","first-page":"2804","article-title":"Patients with sclerosteosis and disease carriers: human models of the effect of sclerostin on bone turnover","volume":"26","author":"van Lierop","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113323828400_B9","first-page":"848","article-title":"Van Buchem disease: clinical, biochemical, and densitometric features of patients and disease carriers","volume":"28","author":"van Lierop","year":"2013","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113323828400_B10","first-page":"150","article-title":"Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis","volume":"62","author":"Daoussis","year":"2010","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2019041113323828400_B11","first-page":"1721","article-title":"Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5","volume":"26","author":"Frost","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113323828400_B12","first-page":"739","article-title":"Bisphosphonate treatment of postmenopausal osteoporosis is associated with a dose dependent increase in serum sclerostin","volume":"50","author":"Gatti","year":"2012","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113323828400_B13","first-page":"1466","article-title":"Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: reduction post-bortezomib monotherapy","volume":"131","author":"Terpos","year":"2012","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113323828400_B14","first-page":"752","article-title":"The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis","volume":"72","author":"Anastasilakis","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113323828400_B15","first-page":"324","article-title":"Sclerostin and DKK1 in primary hyperparathyroidism","volume":"92","author":"Viapiana","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113323828400_B16","first-page":"2259","article-title":"Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab","volume":"27","author":"Gatti","year":"2012","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113323828400_B17","first-page":"348","article-title":"Assessment of circulating Dickkopf-1 with a new two-site immunoassay in healthy subjects and women with breast cancer and bone metastases","volume":"84","author":"Voorzanger-Rousselot","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113323828400_B18","first-page":"965","article-title":"Increased circulating Dickkopf-1 in Paget's disease of bone","volume":"42","author":"Marshall","year":"2009","journal-title":"Clin Biochem"},{"key":"key\n\t\t\t\t2019041113323828400_B19","first-page":"414","article-title":"The role of Dkk1 in bone mass regulation: correlating serum Dkk1 expression with bone mineral density","volume":"29","author":"Butler","year":"2011","journal-title":"J Orthop Res"},{"key":"key\n\t\t\t\t2019041113323828400_B20","first-page":"6199","article-title":"Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium","volume":"110","author":"Ryan","year":"2013","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/2\/E252\/9048316\/jcemE252.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:26:38Z","timestamp":1555025198000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/2\/E252\/2537140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-3278","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}