{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:02:02Z","timestamp":1781478122762,"version":"3.54.1"},"reference-count":29,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1210\/jc.2013-3292","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T02:51:38Z","timestamp":1386039098000},"page":"433-439","source":"Crossref","is-referenced-by-count":60,"title":["The Response to Gonadotropin Releasing Hormone (GnRH) Stimulation Test Does Not Predict the Progression to True Precocious Puberty in Girls With Onset of Premature Thelarche in the First Three Years of Life"],"prefix":"10.1210","volume":"99","author":[{"given":"Carla","family":"Bizzarri","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes Unit (C.B., M.C.), \u201cBambino Ges\u00f9\u201d Children's Hospital, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Spadoni","sequence":"additional","affiliation":[{"name":"Dipartimento Pediatrico Universitario Ospedaliero (G.L.S., G.B., G.M., S.C.), \u201cBambino Ges\u00f9\u201d Children's Hospital-Tor Vergata University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Bottaro","sequence":"additional","affiliation":[{"name":"Dipartimento Pediatrico Universitario Ospedaliero (G.L.S., G.B., G.M., S.C.), \u201cBambino Ges\u00f9\u201d Children's Hospital-Tor Vergata University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Montanari","sequence":"additional","affiliation":[{"name":"Dipartimento Pediatrico Universitario Ospedaliero (G.L.S., G.B., G.M., S.C.), \u201cBambino Ges\u00f9\u201d Children's Hospital-Tor Vergata University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germana","family":"Giannone","sequence":"additional","affiliation":[{"name":"Department of Chemistry (G.G.), \u201cBambino Ges\u00f9\u201d Children's Hospital, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cappa","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Unit (C.B., M.C.), \u201cBambino Ges\u00f9\u201d Children's Hospital, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cianfarani","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health (S.C.), Karolinska Institute, SE 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113313739400_B1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1210\/jcem-42-4-679","article-title":"Pituitary-gonadal relations in infancy. 2. Patterns of serum gonadal steroid concentrations in man from birth to two years of age","volume":"42","author":"Winter","year":"1976","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1203\/00006450-197311000-00006","article-title":"Plasma estrogens in childhood and puberty under physiologic and pathologic conditions","volume":"7","author":"Bidlingmaier","year":"1973","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t2019041113313739400_B3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-3476(95)70254-7","article-title":"Normal ranges for immunochemiluminometric gonadotropin assays","volume":"127","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/beem.2001.0176","article-title":"Regulation of puberty","volume":"16","author":"Delemarre-van de Waal","year":"2002","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B5","first-page":"895","article-title":"Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development","volume":"108","author":"Col\u00f3n","year":"2000","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t2019041113313739400_B6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0022-3476(05)82891-4","article-title":"Natural history of premature thelarche in Olmsted County, Minnesota, 1940 to 1984","volume":"116","author":"Van Winter","year":"1990","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1651-2227.1984.tb17771.x","article-title":"Premature thelarche\u2013natural history and sex hormone secretion in 68 girls","volume":"73","author":"Ilicki","year":"1984","journal-title":"Acta Paediatr Scand"},{"key":"key\n\t\t\t\t2019041113313739400_B8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2265.2004.02198.x","article-title":"Evidence for increased ovarian follicular activity in girls with premature thelarche","volume":"62","author":"Crofton","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113313739400_B9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-70-3-615","article-title":"Serum bioactive follicle-stimulating hormone levels in girls with precocious sexual development","volume":"70","author":"Wang","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000183950","article-title":"Normal and almost normal precocious variations in pubertal development premature pubarche and premature thelarche revisited","volume":"41","author":"Rosenfield","year":"1994","journal-title":"Horm Res"},{"key":"key\n\t\t\t\t2019041113313739400_B11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00446063","article-title":"Studies of gonadotrophin pulsatility and pelvic ultrasound examinations distinguish between isolated premature thelarche and central precocious puberty","volume":"145","author":"Stanhope","year":"1986","journal-title":"Eur J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1136\/adc.57.3.200","article-title":"Premature thelarche: a possible adrenal disorder","volume":"57","author":"Dumic","year":"1982","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113313739400_B13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0022-3476(85)80513-8","article-title":"An epidemic of precocious development in Puerto Rican children","volume":"107","author":"S\u00e1enz de Rodr\u00edguez","year":"1985","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archpedi.1986.02140260065028","article-title":"Premature thelarche in Puerto Rico. A search for environmental factors","volume":"140","author":"Freni-Titulaer","year":"1986","journal-title":"Am J Dis Child"},{"key":"key\n\t\t\t\t2019041113313739400_B15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/09513599609012315","article-title":"Premature thelarche: a long-term follow-up","volume":"10","author":"Verrotti","year":"1996","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t2019041113313739400_B16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF03347298","article-title":"Isolated premature thelarche and thelarche variant: clinical and auxological follow-up of 119 girls","volume":"21","author":"Volta","year":"1998","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113313739400_B17","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1136\/adc.60.12.1180","article-title":"Premature thelarche: a follow up study of 40 girls. Natural history and endocrine findings","volume":"60","author":"Pasquino","year":"1985","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113313739400_B18","unstructured":"WHO Multicentre Growth Reference Study Group. WHO child growth standards: length\/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Geneva: World Health Organization, 2006. http:\/\/www.who.int\/childgrowth\/publications\/technical_report_pub\/en\/index.html."},{"key":"key\n\t\t\t\t2019041113313739400_B19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/adc.51.3.170","article-title":"Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty","volume":"51","author":"Tanner","year":"1976","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113313739400_B20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019041113313739400_B21","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice. Precocious puberty","volume":"358","author":"Carel","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113313739400_B22","volume-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist","author":"Greulich","year":"1971","edition":"2nd ed"},{"key":"key\n\t\t\t\t2019041113313739400_B23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000323361","article-title":"Role of pelvic ultrasound in girls with precocious puberty","volume":"75","author":"de Vries","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jcem-67-3-474","article-title":"Premature thelarche and central precocious puberty: the relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone","volume":"67","author":"Pescovitz","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-3476(95)70492-2","article-title":"Progression of premature thelarche to central precocious puberty","volume":"126","author":"Pasquino","year":"1995","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(95)70255-5","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","volume":"127","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113313739400_B27","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1210\/jcem-71-5-1251","article-title":"Gonadotropin secretory dynamics during puberty in normal girls and boys","volume":"71","author":"Oerter","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113313739400_B29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2605.2004.00487.x","article-title":"Estradiol levels in prepubertal boys and girls\u2013analytical challenges","volume":"27","author":"Bay","year":"2004","journal-title":"Int J Androl"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/2\/433\/9045228\/jcem0433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T10:34:58Z","timestamp":1564914898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/2\/433\/2536842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-3292","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}